Alginate‐Encapsulated Mesenchymal Stromal Cells Improve Hind Limb Ischemia in a Translational Swine Model DOI Creative Commons
Juline Deppen,

Sydney C Ginn,

E. Tang

и другие.

Journal of the American Heart Association, Год журнала: 2024, Номер 13(9)

Опубликована: Апрель 19, 2024

Cellular therapies have been investigated to improve blood flow and prevent amputation in peripheral artery disease with limited efficacy clinical trials. Alginate-encapsulated mesenchymal stromal cells (eMSCs) demonstrated improved retention survival promoted vascular generation murine hind limb ischemia through their secretome, but large animal evaluation is necessary for human applicability. We sought determine the of eMSCs disease-induced assessment our durable swine model.

Язык: Английский

Application of stem cells in regeneration medicine DOI Creative Commons
Ye Jin, Shuangyang Li,

Qixuan Yu

и другие.

MedComm, Год журнала: 2023, Номер 4(4)

Опубликована: Июнь 17, 2023

Abstract Regeneration is a complex process affected by many elements independent or combined, including inflammation, proliferation, and tissue remodeling. Stem cells class of primitive with the potentiality differentiation, regenerate self‐replication, multidirectional immunomodulatory functions. their cytokines not only inextricably linked to regeneration ectodermal skin tissues, but also can be used for treatment variety chronic wounds. produce exosomes in paracrine manner. cell play an important role regeneration, repair, accelerated wound healing, biological properties which are similar stem cells, while safer more effective. Skin bone tissues critical organs body, essential sustaining life activities. The weak repairing ability leads pronounced impact on quality patients, could alleviated treatment. However, there obstacles that trough improved bioavailability. This paper summarizes applications mechanisms healing. We propose new ways utilizing through different nanoformulations, liposomes nanoliposomes, polymer micelles, microspheres, hydrogels, scaffold microneedles, improve use healing regeneration.

Язык: Английский

Процитировано

63

Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease DOI Creative Commons
Defeng Li, Meifeng Yang, Jing Xu

и другие.

International Journal of Nanomedicine, Год журнала: 2022, Номер Volume 17, С. 3893 - 3911

Опубликована: Сен. 1, 2022

Abstract: The recent rapid development in the field of extracellular vesicles (EVs) based nanotechnology has provided unprecedented opportunities for nanomedicine platforms. As natural nanocarriers, EVs such as exosomes, exosome-like nanoparticles and outer membrane (OMVs), have unique structure/composition/morphology characteristics, show excellent physical chemical/biochemical properties, making them a new generation theranostic nanomedicine. Here, we reviewed characteristics from perspective their formation biological function inflammatory bowel disease (IBD). Moreover, can crucially participate interaction communication intestinal epithelial cells (IECs)-immune cells-gut microbiota to regulate immune response, inflammation homeostasis. Interestingly, on current representative examples exosomes IBD treatment, it is shown that plant, milk, cells-derived exert therapeutic effect through components, proteins, nucleic acid, lipids. several drug loading methods target modification are used improve capability. We also discussed application treatment IBD. In this review, aim better more clearly clarify underlying mechanisms pathogenesis IBD, provide directions mediated treatment. Keywords: vesicles, exosome, nanoparticles, disease,

Язык: Английский

Процитировано

43

Effect of platelet-rich plasma on angiogenic and regenerative properties in patients with critical limb ischemia DOI Creative Commons
Hamid Tanzadehpanah, Sima Nobari,

A Hoseini

и другие.

Regenerative Therapy, Год журнала: 2025, Номер 28, С. 517 - 526

Опубликована: Фев. 6, 2025

Язык: Английский

Процитировано

2

Current Status of Angiogenic Cell Therapy and Related Strategies Applied in Critical Limb Ischemia DOI Open Access
Lucía Beltrán-Camacho, Marta Rojas-Torres, Ma Carmen Durán-Ruiz

и другие.

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(5), С. 2335 - 2335

Опубликована: Фев. 26, 2021

Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease (PAD), it is characterized by progressive blockade vessels, commonly correlated to atherosclerosis. Currently, revascularization strategies (bypass grafting, angioplasty) remain first option for CLI patients, although less than 45% them are eligible surgical intervention mainly due associated comorbidities. Moreover, patients usually require amputation in short-term. Angiogenic cell therapy has arisen as a promising alternative these "no-option" with many studies demonstrating potential stem cells enhance promoting vessel formation and blood flow recovery ischemic tissues. Herein, we provide an overview focused on use angiogenic therapies last years, from approaches testing different types animal/pre-clinical models CLI, clinical trials currently under evaluation. Furthermore, recent alternatives related such secretomes, exosomes, or even microRNA, will be also described.

Язык: Английский

Процитировано

54

Emerging Antioxidant Paradigm of Mesenchymal Stem Cell-Derived Exosome Therapy DOI Creative Commons
Chen Xia, Zhanqiu Dai, Yongming Jin

и другие.

Frontiers in Endocrinology, Год журнала: 2021, Номер 12

Опубликована: Ноя. 29, 2021

Mesenchymal stem cell-derived exosomes have been under investigation as potential treatments for a diverse range of diseases, and many animal clinical trials achieved encouraging results. However, it is well known that the biological activity key to their therapeutic properties; however, till date, has not completely understood. Previous studies provided different explanations mechanisms exosomes, including anti-inflammatory, immunomodulatory, anti-aging mechanisms. The pathological effects oxidative stress often include organ damage, inflammation, disorders material energy metabolism. evidence gathered from research involving models indicates antioxidant properties, which can also explain anti-inflammatory cytoprotective effects. In this study, we summarized in vivo vitro models, evaluated anti-oxidant by demonstrating direct reduction excessive reactive oxygen species (ROS), promotion intracellular defence anti-oxidative stress, immunomodulation inhibiting excess ROS, alteration mitochondrial performance. Exosomes exert properties regulating redox environment explains variety be preserved among species.

Язык: Английский

Процитировано

49

Stem cells and common biomaterials in dentistry: a review study DOI Creative Commons
Seyed Ali Mosaddad, Boshra Rasoolzade, Reza Abdollahi Namanloo

и другие.

Journal of Materials Science Materials in Medicine, Год журнала: 2022, Номер 33(7)

Опубликована: Июнь 18, 2022

Abstract Stem cells exist as normal in embryonic and adult tissues. In recent years, scientists have spared efforts to determine the role of stem treating many diseases. can self-regenerate transform into some somatic cells. They would also a special position future various clinical fields, drug discovery, other scientific research. Accordingly, detection safe low-cost methods obtain such is one main objectives Jaw, face, mouth tissues are rich sources cells, which more accessible than so cell tissue engineering treatments dentistry received much attention years. This review study examines three essential elements practice, including derived from intra- extra-oral sources, growth factors, scaffolds.

Язык: Английский

Процитировано

35

A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease DOI Creative Commons
Shekhar Swaroop, Sudheer K. Vuyyuru, Bhaskar Kante

и другие.

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Май 14, 2024

Abstract Background Perianal fistulas (PF) affect one-third patients with Crohn’s disease (CD) limited therapeutic options. There is dearth of literature on safety and efficacy bone marrow-derived mesenchymal stromal cells (BMSCs) in this population. Methods An open-label, phase I/II, single-arm study was conducted involving local administration human allogeneic perianal fistula refractory to standard therapies. Clinical severity biomarkers were assessed at baseline periodically until week 104 , MRI 24 104. Primary secondary objectives assess respectively. Fistula remission complete closure openings < 2 cm collection MRI, response decrease drainage by ≥ 50%. Change activity index, quality-of-life Van Assche index over time using mixed-effect linear regression model. Results Ten (male:8, mean age:27.4 ± 12.0years) recruited. Self-resolving procedure-related adverse events occurred three patients, no follow-up events. In intention treat analysis 24, two (20%) achieved seven (70%) had response. At 52, maintained weeks, one (10%) remission. Statistically significant ( P = 0.008), Index 0.008) improvement 0.001) observed time. Conclusions Allogeneic BMSCs are safe effective for the treatment fistulizing CD clinical radiological healing. Trial registration The prospectively registered trials registry – India (CTRI), CTRI/2020/01/022743 14 January 2020, http://ctri.nic.in .

Язык: Английский

Процитировано

7

Mesenchymal Stem Cells in Soft Tissue Regenerative Medicine: A Comprehensive Review DOI Creative Commons
Ayesha Rehman, Aditya Nigam, Luigi Laino

и другие.

Medicina, Год журнала: 2023, Номер 59(8), С. 1449 - 1449

Опубликована: Авг. 10, 2023

Soft tissue regeneration holds significant promise for addressing various clinical challenges, ranging from craniofacial and oral defects to blood vessels, muscle, fibrous regeneration. Mesenchymal stem cells (MSCs) have emerged as a promising tool in regenerative medicine due their unique characteristics potential differentiate into multiple cell lineages. This comprehensive review explores the role of MSCs different aspects soft regeneration, including application nerve vessel muscle By examining latest research findings advancements, this article aims provide insights current state MSC-based therapies medicine.

Язык: Английский

Процитировано

17

Prostaglandin E1 reduces apoptosis and improves the homing of mesenchymal stem cells in pulmonary arterial hypertension by regulating hypoxia-inducible factor 1 alpha DOI Creative Commons

Detian Jiang,

Lei Tuo, Xiao Bai

и другие.

Stem Cell Research & Therapy, Год журнала: 2022, Номер 13(1)

Опубликована: Июль 16, 2022

Abstract Background Pulmonary arterial hypertension (PAH) is associated with oxidative stress and affects the survival homing of transplanted mesenchymal stem cells (MSCs) as well cytokine secretion by MSCs, thereby altering their therapeutic potential. In this study, we preconditioned MSCs prostaglandin E1 (PGE1) performed in vitro vivo cell experiments to evaluate effects rats PAH. Methods We studied relationship between PGE1 vascular endothelial growth factor (VEGF) secretion, B-cell lymphoma 2 (Bcl-2) expression, C-X-C chemokine receptor 4 (CXCR4) expression MSC apoptosis migration through hypoxia-inducible (HIF) pathway vitro. The experimental were randomly divided into five groups: (I) control group, (II) monocrotaline (MCT) (III) MCT + non-preconditioned (Non-PC) (IV) PGE1-preconditioned (PGE1-PC) (V) +PGE1+YC-1-PC group. methane dicarboxylic aldehyde (MDA) levels, rat lungs, mean pulmonary artery pressure, systolic right ventricular hypertrophy index, wall thickness index (%WT), relative area (%WA) arterioles. Results Preconditioning increased protein levels HIF-1 alpha (HIF-1α) which can reduce increase CXCR4, migration, secretion. Upon injection PGE1-PC %WT, %WA decreased exhibited better than non-PC MSCs. Interestingly, lificiguat (YC-1), an inhibitor HIF pathway, blocked preconditioning. Conclusions Our findings indicate that modulates properties regulating providing insights mechanism preconditioning be used improve potential

Язык: Английский

Процитировано

21

Engineering M2-type macrophages with a metal polyphenol network for peripheral artery disease treatment DOI

Jianwei Duan,

Zuoguan Chen,

Xiaoyu Liang

и другие.

Free Radical Biology and Medicine, Год журнала: 2024, Номер 213, С. 138 - 149

Опубликована: Янв. 11, 2024

Язык: Английский

Процитировано

5