Elsevier eBooks, Год журнала: 2023, Номер unknown, С. 257 - 269
Опубликована: Сен. 29, 2023
Язык: Английский
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Май 8, 2025
Язык: Английский
Процитировано
0
Digital Health, Год журнала: 2025, Номер 11
Опубликована: Май 1, 2025
Neurodegenerative diseases, including Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, leading to cognitive motor impairments. Early diagnosis remains a challenge due the slow progression of symptoms limitations current diagnostic methods. Nanobiosensors, leveraging high sensitivity specificity nanotechnology, offer promising, noninvasive, cost-effective approach for detecting disease biomarkers at ultra-low concentrations. This review highlights recent advancements in nanobiosensor technology, integration gold nanoparticles, quantum dots, carbon nanotubes, which have significantly enhanced biomarker detection precision. Furthermore, it examines advantages nanobiosensors over traditional techniques, such as improved sensitivity, rapid detection, minimal invasiveness. The potential these innovative sensors revolutionize early improve patient outcomes is discussed, along with existing challenges clinical translation, stability, reproducibility, regulatory considerations. Addressing will be crucial integrating into routine practice advancing personalized medicine neurodegenerative disorders.
Язык: Английский
Процитировано
0
The Egyptian Journal of Neurology Psychiatry and Neurosurgery, Год журнала: 2022, Номер 58(1)
Опубликована: Авг. 8, 2022
Abstract Background Autism spectrum disorders (ASD) include a group of neurodevelopmental characterised by repetitive behaviours and impairments in communication, emotional social skills. This review gives an overview ASD, focusing on the aetiological clinical aspects. It also discusses role neuroinflammation critically examines current evidence therapeutic effects MSCs ASD consolidates key findings this area research. Results Many environmental genetic factors have been linked to aetiology ASD. has become increasingly evident that plays Conventional treatment revolves around psychosocial approaches whereas recent studies turned alternative such as mesenchymal stem cell (MSC)-based therapy, owing well-recognised immunomodulatory characteristics MSCs. Preclinical shown were able exert anti-inflammatory alleviate symptoms. Conclusions There are many preclinical support use However, there relatively fewer concerning safety efficacy which warrants more large-scale for future
Язык: Английский
Процитировано
13
Journal of Composites and Compounds, Год журнала: 2021, Номер 3(3), С. 194 - 205
Опубликована: Окт. 1, 2021
Tissue engineering (TE) employs biological, chemical, and methods to regenerate restore injured or lost living tissues by applying biologically activated biomaterials, cells, molecules. The fast convenient restoration of tissue is a great challenge, emphasizing the need imitate structure its physicochemical, mechanical behavior give back desired functionality damaged tissue. Depending on particular tissue, numerous requirements have be fulfilled with help material scaffold design that provides base for cell adhesion proliferation. As result, countless biodegradable bioresorbable materials been extensively examined. Composite systems combine benefits bioactive ceramics polymers, which seem good alternatives bone engineering. This article intends introduce polymer, methods, kinds biomaterials applied in invention, different approaches producing polymer-based composites various structures such as porous, membrane, 3D structure. Biomaterials invention techniques could crucially influence consequences scaffold's architectures, proliferation, behavior. Moreover, an excellent assists generation provision nutrients human body their characteristics.
Язык: Английский
Процитировано
18
Molecular Immunology, Год журнала: 2022, Номер 150, С. 1 - 8
Опубликована: Июль 28, 2022
Bone marrow-derived mesenchymal stem cells (BMSCs) have been widely studied for their applications in immunoregulation and tissue repair. However, the therapeutic effects of BMSCs body are limited, partly due to low homing efficiency affected parts. The stromal cell-derived factor 1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis is well known play an essential role BMSCs. Interleukin 35 (IL-35) a newly discovered cytokine confirmed inhibit overactivated immune function good effect on autoimmune diseases. In this study, we innovatively developed dual gene modification by transducing CXCR4 IL-35 found that migration immunomodulatory activity genetically engineered were significantly enhanced compared natural counterparts. These results suggest modified overexpression may provide potential treatment strategy
Язык: Английский
Процитировано
8
Journal of Composites and Compounds, Год журнала: 2022, Номер 4(10), С. 21 - 30
Опубликована: Март 30, 2022
Skin tissue engineering and wound healing are two applications where conductive biomaterials based on metal compounds, polymers, or piezoelectric polymers have great potential. This is because of their excellent antibacterial antioxidant activities, similar conductivity to human skin, photothermal effect, electrically controlled drug delivery. Wound can be accelerated by using materials stimulate the activity responsive cells. Electroactive dressings made combining non-conductive with this article focuses current developments in area. It detailed how these electroactive (conductive metal-based, piezoelectric-based dressings) accelerate process, properties examined. Furthermore, electrical stimulation techniques for accelerating discussed. The possibility used vivo track progress also mentioned, as future development directions.
Язык: Английский
Процитировано
6
Journal of Composites and Compounds, Год журнала: 2022, Номер 4(10), С. 31 - 40
Опубликована: Март 30, 2022
Early detection of neurodegeneration-related disorders that emerge as people age, is critical for both the disease's treatment and patient's living conditions. Parkinson's Alzheimer's illnesses are two well-known instances neurodegeneration, which characterized by nerve cell death dementia. The fact some only diagnosed clinically after symptoms develop hinders therapy. biomarkers detection, unique chemicals found in bodily fluids implicated neurodegenerative processes, may assist early illnesses. Recent years have seen a surge interest biosensor research, with goal detecting possible process appropriate precision. Biosensors' main purpose to identify specific material high specificity. This manuscript reviews neuro-biosensors prognosis like disease (PD) (AD), well summary field's urgent needs, highlighting importance along neurodegeneration pathway general. study examines systems designed diseases (NDDs), an emphasis on last five years.
Язык: Английский
Процитировано
6
Neural Regeneration Research, Год журнала: 2022, Номер 18(7), С. 1563 - 1563
Опубликована: Окт. 14, 2022
The neuronal differentiation of mesenchymal stem cells offers a new strategy for the treatment neurological disorders. Thus, there is need to identify noninvasive and sensitive in vivo imaging approach real-time monitoring transplanted cells. Our previous study confirmed that magnetic resonance imaging, with focus on ferritin heavy chain 1 reporter gene, could track proliferation bone marrow had been transduced lentivirus carrying gene. However, we not determine whether or when undergone based changes signal. To solve this problem, identified neuron-specific enolase can be differentially expressed before after In study, successfully constructed promoter expressing gene; used transduce Cellular animal studies showed effectively drove expression cells; led intracellular accumulation iron corresponding summary, established an innovative focused induction gene by promoter. This method noninvasively sensitively detect cells, which may useful cell-based therapies.
Язык: Английский
Процитировано
2
Research Square (Research Square), Год журнала: 2023, Номер unknown
Опубликована: Июнь 13, 2023
Abstract Objective Mesenchymal stem cells (MSCs) due to their immunomodulatory, neurogenerative and self-renewal features have achieved fascinating prospects in regenerative medicine. Adipose tissue is an optimal source of MSCs because the high abundance proliferative rate this tissue. To date, utilized for curing MS been cryopreserved, almost derived from bone marrow, infused at standard doses (1–2×10 6 cell/Kg). Methods Here, we explored safety, tolerability functionality fresh dose (4.4×10 cell/Kg) autologous adipose (AT-MSCs) 10 female patients with secondary progressive (SPMS, EDSS = 4–6). end, assessed adverse events AT-MSCs administration 9 months following transplantation. Additionally, measured number volume lesions, as well contrast-enhancing lesions magnetic resonance imaging (MRI) data. Furthermore, evaluated expanded disability status scale (EDSS), depression, quality life over months. Also, immunomodulatory effect was investigated by evaluating gene expression inflammatory (IL1, IL6, IL17, IFN-γ) anti-inflammatory (TGF-β, IL4, IL10, FOXP3) cytokines besides proportion peripheral blood T regulatory important modifier hemostasis autoimmune responses diseases. Results In our study, non-cryopreserved were successfully administrated into SPMS during two injections seven days apart. Our findings shown that no serious side effects after one year. noted efficacy terms reduction numbers T2-FLAIR ameliorating EDSS, improvement psychological criteria. Moreover, confirmed enhancing Tregs population lowering patients. Conclusion Administration high-dose safe tolerated can be considered efficient treatment stop or even reverse neurological manifestations phase multiple sclerosis. Trial registration : This clinical trial study registered Iranian Registry Clinical Trials (Reference: IRCT20091127002778N1 2018-01-10).
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2023, Номер unknown, С. 257 - 269
Опубликована: Сен. 29, 2023
Язык: Английский
Процитировано
0