International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 5561 - 5578
Опубликована: Сен. 1, 2023
Abstract:
Degenerative
bone
disorders
such
as
intervertebral
disc
degeneration
(IVDD),
osteoarthritis
(OA),
and
osteoporosis
(OP)
pose
significant
health
challenges
for
aging
populations
lack
effective
treatment
options.
The
field
of
regenerative
medicine
holds
promise
in
addressing
these
disorders,
with
a
focus
on
utilizing
extracellular
vesicles
(EVs)
derived
from
stem
cells
an
innovative
therapeutic
approach.
EVs
have
shown
great
potential
stimulating
biological
responses,
making
them
attractive
candidate
rejuvenating
degenerative
disorders.
However,
comprehensive
review
summarizing
the
current
state
this
providing
clear
assessment
EV-based
therapies
is
currently
deficient.
In
review,
we
aim
to
fill
existing
gap
by
outlining
knowledge
role
different
types
cells,
mesenchymal
embryonic
induced
pluripotent
regeneration.
Furthermore,
discuss
treatments
IVDD,
OA,
OP.
By
substantiating
use
cell-derived
EVs,
highlight
their
promising
cell-free
strategy
improve
Keywords:
nanomedicine,
vesicles,
regeneration,
therapy
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 3219 - 3234
Опубликована: Март 1, 2025
Osteoarthritis
(OA)
is
characterized
by
the
degeneration
of
articular
cartilage
caused
several
factors
which
novel
most
trends
include
microbiota.
Specific
microbiota
and
role
in
development
OA
less
clear.
The
presumed
to
influence
occurrence
progression
mainly
via
immune
modulation.
In
recent
years,
bone
marrow
mesenchymal
stem
cells
(MSCs)
have
shown
great
potential
for
treatment
OA,
however,
therapeutic
efficiency
has
been
seriously
affected
harsh
microenvironment
joint
cavity.
At
present,
many
strategies
used
enhance
function
MSCs,
among
them,
engineering
are
a
promising
method.
Therefore,
this
review
focuses
on
latest
research
how
affects
cell
repair,
use
engineered
MSCs
OA.
addition,
can
exosomes
as
strategy
treating
Our
provides
comprehensive
perspective
therapy
Materials Today Bio,
Год журнала:
2022,
Номер
15, С. 100310 - 100310
Опубликована: Май 28, 2022
Functional
repair
of
articular
cartilage
defects
is
always
a
great
challenge
in
joint
surgery
clinically.
Tissue
engineering
strategies
that
combine
autologous
cell
implantation
with
three-dimensional
scaffolds
have
proven
effective
for
repairing
tissue.
However,
it
faces
the
problem
sources
and
scaffold
materials.
Autologous
chondrocytes
bone
marrow
are
difficult
to
popularize
clinically
due
limited
donor
low
mononuclear
(MNC)
concentrations,
respectively.
The
density
gradient
centrifugation
method
can
increase
concentration
MNCs
fresh
by
nearly
hundredfold
achieve
immediate
enrichment.
In
addition,
acellular
matrix
(ACM),
good
biocompatibility
cartilage-specific
microenvironment,
considered
be
an
ideal
candidate
regeneration.
this
study,
hybrid
pigs
were
used
establish
defect
models
different
sizes
determine
feasibility
maximum
scope
application
ACM-based
biomimetic
combined
inducing
Importantly,
instantly
enriched
could
improve
effect
situ,
which
established
new
model
regeneration
applied
immediately
suited
large-scale
clinical
promotion.
current
study
significantly
improves
defects,
provides
scientific
evidence
detailed
insights
future
applications
MNCs.
Cells,
Год журнала:
2022,
Номер
11(15), С. 2305 - 2305
Опубликована: Июль 27, 2022
Osteoarthritis
(OA)
is
a
degenerative
disease
that
causes
irreversible
destruction
of
articular
cartilage
for
which
there
no
effective
treatment
at
present.
Although
lacks
intrinsic
reparative
capacity,
numerous
studies
have
confirmed
the
existence
cartilage-resident
stem/progenitor
cells
(CSPCs)
in
superficial
zone
(SFZ)
cartilage.
CSPCs
are
characterized
by
expression
mesenchymal
stromal
cell
(MSC)-related
surface
markers,
multilineage
differentiation
ability,
colony
formation
and
migration
ability
response
to
injury.
In
contrast
MSCs
chondrocytes,
exhibit
extensive
proliferative
chondrogenic
potential
with
signs
hypertrophic
differentiation,
highlighting
them
as
suitable
sources
repair.
this
review,
we
focus
on
organizational
distribution,
cytological
features
roles
development,
homeostasis
repair,
application
repair
OA
therapies.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 5561 - 5578
Опубликована: Сен. 1, 2023
Abstract:
Degenerative
bone
disorders
such
as
intervertebral
disc
degeneration
(IVDD),
osteoarthritis
(OA),
and
osteoporosis
(OP)
pose
significant
health
challenges
for
aging
populations
lack
effective
treatment
options.
The
field
of
regenerative
medicine
holds
promise
in
addressing
these
disorders,
with
a
focus
on
utilizing
extracellular
vesicles
(EVs)
derived
from
stem
cells
an
innovative
therapeutic
approach.
EVs
have
shown
great
potential
stimulating
biological
responses,
making
them
attractive
candidate
rejuvenating
degenerative
disorders.
However,
comprehensive
review
summarizing
the
current
state
this
providing
clear
assessment
EV-based
therapies
is
currently
deficient.
In
review,
we
aim
to
fill
existing
gap
by
outlining
knowledge
role
different
types
cells,
mesenchymal
embryonic
induced
pluripotent
regeneration.
Furthermore,
discuss
treatments
IVDD,
OA,
OP.
By
substantiating
use
cell-derived
EVs,
highlight
their
promising
cell-free
strategy
improve
Keywords:
nanomedicine,
vesicles,
regeneration,
therapy
