Cell Biochemistry and Function,
Год журнала:
2024,
Номер
42(4)
Опубликована: Май 21, 2024
Mesenchymal
stem
cell-derived
exosomes
(MSC-Exos)
are
emerging
as
remarkable
agents
in
the
field
of
immunomodulation
with
vast
potential
for
diagnosing
and
treating
various
diseases,
including
cancer
autoimmune
disorders.
These
tiny
vesicles
laden
a
diverse
cargo
encompassing
proteins,
nucleic
acids,
lipids,
bioactive
molecules,
offering
wealth
biomarkers
therapeutic
options.
MSC-Exos
exhibit
their
immunomodulatory
prowess
by
skillfully
regulating
pattern-recognition
receptors
(PRRs).
They
conduct
symphony
immunological
responses,
modulating
B-cell
activities,
polarizing
macrophages
toward
anti-inflammatory
phenotypes,
fine-tuning
T-cell
activity.
interactions
have
profound
implications
precision
medicine,
immunotherapy,
disease
management,
biomarker
discovery,
regulatory
approvals.
promises
to
usher
new
era
tailored
therapies,
personalized
diagnostics,
more
effective
treatments
medical
conditions.
As
research
advances,
transformative
healthcare
becomes
increasingly
evident.
Stem Cell Research & Therapy,
Год журнала:
2023,
Номер
14(1)
Опубликована: Июнь 26, 2023
The
main
causes
of
death
in
patients
with
severe
Coronavirus
disease-2019
(COVID-19)
are
acute
respiratory
distress
syndrome
(ARDS)
and
multiorgan
failure
caused
by
a
inflammatory
cascade.
Novel
treatment
strategies,
such
as
stem-cell-based
therapy
their
derivatives
can
be
used
to
relieve
inflammation
these
cases.
In
this
study,
we
aimed
evaluate
the
safety
efficacy
using
mesenchymal
stromal
cells
(MSCs)
derived
extracellular
vesicles
COVID-19
patients.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Окт. 8, 2022
Abstract
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
led
to
COVID-19
and
has
become
a
pandemic
worldwide
with
mortality
of
millions.
Nanotechnology
can
be
used
deliver
antiviral
medicines
or
other
types
viral
reproduction-inhibiting
medications.
At
various
steps
infection,
nanotechnology
could
suggest
practical
solutions
for
usage
in
the
fight
against
infection.
Nanotechnology-based
approaches
help
SARS-CoV-2
Nanoparticles
play
an
essential
role
progressing
treatment
vaccine
production
efficacy
safety.
Nanocarriers
have
increased
speed
development
efficiency
vaccines.
As
result,
investigation
into
nanoparticles
as
nano-delivery
systems
nanotherapeutics
new
effective
methods
are
inhibiting
In
this
article,
we
compare
attributes
several
evaluate
their
capability
create
novel
vaccines
different
diseases,
especially
disease.
Graphical
Frontiers in Neurology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 5, 2025
Traumatic
brain
injury
(TBI)
is
a
complex
condition
involving
mechanisms
that
lead
to
dysfunction
and
nerve
damage,
resulting
in
significant
morbidity
mortality
globally.
Affecting
~50
million
people
annually,
TBI's
impact
includes
high
death
rate,
exceeding
of
heart
disease
cancer.
Complications
arising
from
TBI
encompass
concussion,
cerebral
hemorrhage,
tumors,
encephalitis,
delayed
apoptosis,
necrosis.
Current
treatment
methods,
such
as
pharmacotherapy
with
dihydropyridines,
high-pressure
oxygen
therapy,
behavioral
non-invasive
stimulation,
have
shown
limited
efficacy.
A
comprehensive
understanding
vascular
components
essential
for
developing
new
treatments
improve
blood
vessel-related
damage.
Recently,
mesenchymal
stem
cells
(MSCs)
promising
results
repairing
mitigating
Studies
indicate
MSCs
can
promote
neurogenesis
angiogenesis
through
various
mechanisms,
including
releasing
bioactive
molecules
extracellular
vesicles
(EVs),
which
help
reduce
neuroinflammation.
In
research,
the
distinctive
characteristics
positioned
them
highly
desirable
cell
sources.
Extensive
investigations
been
conducted
on
regulatory
properties
their
manipulation,
tagging,
transportation
techniques
brain-related
applications.
This
review
explores
progress
prospects
MSC
therapy
TBI,
focusing
action,
therapeutic
benefits,
challenges
potential
limitations
using
treating
neurological
disorders.
In
December
2019,
Coronavirus
Disease
2019
(COVID-19)
was
reported
in
Wuhan,
China.
Comprehensive
strategies
for
quick
identification,
prevention,
control,
and
remedy
of
COVID-19
have
been
implemented
until
today.
Advances
various
nanoparticle-based
technologies,
including
organic
inorganic
nanoparticles,
created
new
perspectives
this
field.
These
materials
were
extensively
used
to
control
because
their
specific
attribution
preparing
antiviral
face
masks,
safety
sensors,
etc.
review,
the
most
current
applications,
achievements
against
coronavirus
summarized
highlighted.
This
paper
also
offers
nanoparticle
preventive,
diagnostic,
treatment
options
combat
pandemic.
Cancer Cell International,
Год журнала:
2023,
Номер
23(1)
Опубликована: Ноя. 20, 2023
Abstract
Carcinoma
of
the
lung
is
among
most
common
types
cancer
globally.
Concerning
its
histology,
it
categorized
as
a
non-small
cell
carcinoma
(NSCLC)
and
small
(SCLC)
subtype.
MicroRNAs
(miRNAs)
are
member
non-coding
RNA
whose
nucleotides
range
from
19
to
25.
They
known
be
critical
regulators
via
epigenetic
control
oncogenes
expression
by
regulating
tumor
suppressor
genes.
miRNAs
have
an
essential
function
in
tumorous
microenvironment
modulating
growth,
metastasis,
angiogenesis,
metabolism,
apoptosis.
Moreover,
wide
information
produced
several
investigations
indicates
their
tumor-suppressing,
oncogenic,
diagnostic
assessment,
predictive
marker
functions
different
malignancy.
miRNA
mimics
or
anti-miRNAs
can
transferred
into
cell,
with
possible
curative
implications.
As
result,
hold
promise
targets
for
treatment
detection.
In
this
study,
we
investigate
various
malignancy,
which
been
achieved
recent
years
that
show
cancer-associated
regulation
expression,
concerning
beginning,
development,
resistance
chemotherapy,
also
probability
utilize
biomarkers
therapy
reaction.
Graphical
abstract
Cell Communication and Signaling,
Год журнала:
2023,
Номер
21(1)
Опубликована: Апрель 24, 2023
Aging
is
a
biological
process
determined
through
time-related
cellular
and
functional
impairments,
leading
to
decreased
standard
of
living
for
the
organism.
Recently,
there
has
been
an
unprecedented
advance
in
aging
investigation,
especially
detection
that
rate
senescence
at
least
somewhat
regulated
via
evolutionarily
preserved
genetic
pathways
processes.
Hematopoietic
stem
cells
(HSCs)
maintain
blood
generation
over
whole
lifetime
The
influences
many
natural
features
HSC,
decline
their
capabilities,
independently
microenvironment.
New
studies
show
HSCs
are
sensitive
age-dependent
stress
gradually
lose
self-renewal
regeneration
potential
with
senescence.
MicroRNAs
(miRNAs)
short,
non-coding
RNAs
post-transcriptionally
inhibit
translation
or
stimulate
target
mRNA
cleavage
transcripts
sequence-particular
connection.
MiRNAs
control
various
processes,
such
as
Several
miRNAs
differentially
expressed
senescence,
producing
concern
about
use
moderators
process.
play
important
role
can
also
modulate
processes
associated
tissue
specific
cell
types.
In
this
review,
we
display
contribution
alterations,
including
DNA
damage,
epigenetic
landscape,
metabolism,
extrinsic
factors,
which
affect
function
during
aging.
addition,
investigate
particular
regulating
age-associated
diseases.
Video
Abstract.
Abstract
Viral
infections
in
humans
are
responsible
for
fatalities
worldwide
and
contribute
to
the
incidence
of
various
human
ailments.
Controllable
targeted
medicine
delivery
against
many
illnesses,
including
viral
infection,
may
be
significantly
aided
by
using
bacteria
bacteria-derived
products.
They
accumulate
diseased
tissues
despite
physical
obstacles,
where
they
can
launch
antiviral
immunity.
The
ability
genetically
chemically
modify
them
means
that
vaccinations
manufactured
delivered
affected
more
safely
effectively.
objective
this
study
is
provide
an
overview
latest
advancements
field
utilizing
bacterial
derivatives
as
carriers
administering
medication
treat
diseases
such
SARS-CoV-2,
hepatitis
B
virus,
C
immunodeficiency
papillomavirus,
influenza,
Ebola
virus.
Graphical
