Antiviral Research, Год журнала: 2021, Номер 195, С. 105192 - 105192
Опубликована: Окт. 21, 2021
Язык: Английский
Current Opinion in Virology, Год журнала: 2019, Номер 34, С. 97 - 103
Опубликована: Фев. 1, 2019
Язык: Английский
Процитировано
156
Virus Evolution, Год журнала: 2021, Номер 7(1)
Опубликована: Янв. 1, 2021
Abstract Revealing the determinants of virome composition is central to placing disease emergence in a broader evolutionary context. Fish are most species-rich group vertebrates and so provide an ideal model system study factors that shape compositions their evolution. We characterized viromes nineteen wild-caught species marine fish using total RNA sequencing (meta-transcriptomics) combined with analyses sequence protein structural homology identify divergent viruses often evade characterization. From this, we identified twenty-five new vertebrate-associated further twenty-two likely associated diet or microbiomes. The here included first virus Matonaviridae (single-strand, positive-sense virus). Other fell within Astroviridae, Picornaviridae, Arenaviridae, Reoviridae, Hepadnaviridae, Paramyxoviridae, Rhabdoviridae, Hantaviridae, Filoviridae, Flaviviridae, were sometimes phylogenetically distinct from known viruses. also show how key metrics composition—viral richness, abundance, diversity—can be analysed along host ecological biological as means understand ecology. Accordingly, these data suggest sampled predominantly shaped by phylogenetic history (i.e. taxonomic order) hosts, several including water temperature, habitat depth, community diversity swimming behaviour. No such correlations found for porifera, molluscs, arthropods, fungi, algae, unlikely replicate hosts. Overall, indicate harbour particularly large complex vast majority undescribed.
Язык: Английский
Процитировано
89
Microbiome, Год журнала: 2024, Номер 12(1)
Опубликована: Янв. 13, 2024
Abstract Background The visual organ plays a crucial role in sensing environmental information. However, its mucosal surfaces are constantly exposed to selective pressures from aquatic or airborne pathogens and microbial communities. Although few studies have characterized the conjunctival-associated lymphoid tissue (CALT) ocular mucosa (OM) of birds mammals, little is known regarding evolutionary origins functions immune defense microbiota homeostasis OM early vertebrates. Results Our study structure ecosystem rainbow trout (Oncorhynchus mykiss ) confirmed for first time presence diffuse mucosal-associated (MALT) fish OM. Moreover, communities residing on surface contribute shaping environment. Interestingly, following IHNV infection, we observed robust responses, significant damage, dysbiosis OM, particularly fornix conjunctiva (FC), which by increase pathobionts reduction beneficial taxa relative abundance Critically, identified correlation between viral-induced responses microbiome underscoring key immunity homeostasis. Conclusions findings suggest that occurred concurrently vertebrate species, shedding light coevolution immunity.
Язык: Английский
Процитировано
14
Aquaculture, Год журнала: 2025, Номер unknown, С. 742123 - 742123
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Conservation Physiology, Год журнала: 2017, Номер 5(1)
Опубликована: Янв. 1, 2017
Infectious diseases can impact the physiological performance of individuals, including their mobility, visual acuity, behavior and tolerance ability to effectively respond additional stressors. These effects influence competitiveness, social hierarchy, habitat usage, migratory risk predation, in some circumstances, viability populations. While there are multiple means detecting infectious agents (microscopy, culture, molecular assays), detection wild populations circumstances where mortality is not observable be difficult. Moreover, if infection-related compromise leaves individuals vulnerable it may rare observe wildlife a late stage disease. Diagnostic technologies designed diagnose cause death always sensitive enough detect early stages disease development live-sampled organisms. Sensitive that differentiate agent carrier states from active required demonstrate impacts We present discovery validation salmon host transcriptional biomarkers capable distinguishing fish an viral state [viral (VDD)] those carrying latent infection, versus bacterial states. Biomarker was conducted through meta-analysis published in-house microarray data, performed on independent datasets challenge studies farmed diagnosed with various viral, parasitic diseases. VDD biomarker panel predictive across RNA-viral species, species tissues, recognize wild-migrating salmon. we show considerable overlap resolved our study based similar human influenza research, suggesting highly conserved suite genes associated applicable broad range vertebrate taxa.
Язык: Английский
Процитировано
78
Reviews in Aquaculture, Год журнала: 2020, Номер 13(1), С. 189 - 237
Опубликована: Июль 26, 2020
Abstract Combating and controlling sea lice causes large economic costs for the farmers, with estimated values of more than 305 million euros (€) per year. Increased resistance against traditional chemotherapeutants due to evolutionary drivers in combined lack an effective vaccine few other chemical treatments available are expected cause these increase. Several possible methods managing infestations have been investigated, but only cleaner fish has proven effect on levels. Cleaning activity is well known marine observed wild as a form symbiosis between two species: one species, ‘client’ fish, seek out ‘cleaner’ ectoparasites dead tissue cleared from its body. The Atlantic lumpfish relatively new aquaculture wild‐caught mature used brood stock farmed production. This poses biosecurity risk, can carry pathogens, use quarantine health screening recommended. Vaccine development unfortunately lagging far behind wide spread high utilisation fish. review contains description main pathogens diseases that affect
Язык: Английский
Процитировано
66
Bioorganic & Medicinal Chemistry Letters, Год журнала: 2019, Номер 29(14), С. 1749 - 1755
Опубликована: Май 14, 2019
Язык: Английский
Процитировано
57
The Science of The Total Environment, Год журнала: 2022, Номер 866, С. 161191 - 161191
Опубликована: Дек. 31, 2022
Язык: Английский
Процитировано
34
Molecules, Год журнала: 2022, Номер 27(14), С. 4457 - 4457
Опубликована: Июль 12, 2022
Pandemics from various viruses make natural organisms face challenges over and again. Therefore, new antiviral drugs urgently need to be found solve this problem. However, drug research development is a very difficult task, finding compounds desirable. A range of medicinal fungi such as Ganoderma lucidum Cordyceps sinensis are widely used all the world, they can enhance human immunity direct anti-virus activities other aspects play an role. Medicinal foods or food supplements. In review, species with activity in recent decades mechanism components were reviewed perspectives human, animal, plant provide comprehensive theory based on better clinical utilization agents.
Язык: Английский
Процитировано
32
Journal of Virological Methods, Год журнала: 2024, Номер 326, С. 114892 - 114892
Опубликована: Фев. 7, 2024
Язык: Английский
Процитировано
9