Asia-Pacific Journal of Oncology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 11, 2024
Senescence
is
irreversible
cell
cycle
arrest
that
results
from
therapy-induced
stress
such
as
DNA
damage.
It
was
initially
thought
to
be
a
tumor-suppressive
mechanism,
but
now
getting
attention
contribute
tumor
progression
and
therapy
resistance
through
the
senescence-associated
secretory
phenotype
(SASP).
Remodeling
microenvironment
(TME),
SASP
can
establish
conditions
conducive
progression.
In
addition,
senescence
being
acknowledged
increasingly
crucial
factor
in
inducing
dormancy,
state
of
reversible
quiescence
allows
cancer
cells
evade
therapeutic
clearance
survive
protective
niches.
Eventually,
both
dormancy
significantly
maintenance
stem
(CSCs),
enhancing
their
plasticity
tumor-initiating
potential.
Moreover,
promote
aggressive
disease
cells,
driving
epithelial-to-mesenchymal
transition
(EMT)
metastasis.
On
other
hand,
dormant
act
reservoir,
serving
seeds
for
metastatic
spread
which
reactivate
develop
at
secondary
sites.
Understanding
mechanisms
holds
promise
overcoming
resistance,
stemness
Therapeutic
strategies
targeting
include
senolytics,
senomorphics,
dormancy-disrupting
agents,
immunotherapies.
Future
preclinical
clinical
research
should
prioritize
integration
senescence-
dormancy-targeting
agents
with
conventional
treatments
achieve
durable
control.
The EPMA Journal,
Год журнала:
2024,
Номер
15(2), С. 163 - 205
Опубликована: Апрель 18, 2024
Despite
their
subordination
in
humans,
to
a
great
extent,
mitochondria
maintain
independent
status
but
tightly
cooperate
with
the
"host"
on
protecting
joint
life
quality
and
minimizing
health
risks.
Under
oxidative
stress
conditions,
healthy
promptly
increase
mitophagy
level
remove
damaged
"fellows"
rejuvenating
mitochondrial
population
sending
fragments
of
mtDNA
as
SOS
signals
all
systems
human
body.
As
long
metabolic
pathways
are
under
systemic
control
well-concerted
together,
adaptive
mechanisms
become
triggered
increasing
protection,
activating
antioxidant
defense
repair
machinery.
Contextually,
attributes
patho-/physiology
instrumental
for
predictive
medical
approach
cost-effective
treatments
tailored
individualized
patient
profiles
primary
(to
protect
vulnerable
individuals
again
health-to-disease
transition)
secondary
affected
disease
progression)
care.
Nutraceuticals
naturally
occurring
bioactive
compounds
demonstrating
health-promoting,
illness-preventing,
other
health-related
benefits.
Keeping
mind
health-promoting
properties
nutraceuticals
along
therapeutic
potential
safety
profile,
there
is
permanently
growing
demand
application
mitochondria-relevant
nutraceuticals.
Application
beneficial
only
if
meeting
needs
at
individual
level.
Therefore,
risk
assessment
creation
pivotal
importance
followed
by
adapted
nutraceutical
sets
needs.
Based
scientific
evidence
available
nutraceuticals,
this
article
presents
examples
frequent
which
require
protective
measures
targeted
holistic
following
advanced
concepts
predictive,
preventive,
personalized
medicine
(PPPM/3PM)
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
This
comprehensive
review
navigates
the
complex
relationship
between
cellular
aging,
senescence,
and
cancer,
unraveling
determinants
of
fate.
Beginning
with
an
overview
aging's
significance
in
explores
processes,
changes,
molecular
pathways
influencing
senescence.
The
senescence
as
a
dual
mechanism
acting
suppressor
contributor,
focusing
on
its
impact
therapy
response.
highlights
opportunities
for
cancer
therapies
that
target
further
examines
senescence-associated
secretory
phenotype
strategies
to
modulate
aging
influence
tumor
behavior.
Additionally,
mechanisms
escape
cells,
emphasizing
their
prognosis
resistance
therapy.
article
addresses
current
advances,
unexplored
aspects,
future
perspectives
understanding
cancer.
Neurotherapeutics,
Год журнала:
2025,
Номер
22(3), С. e00519 - e00519
Опубликована: Янв. 6, 2025
Cellular
senescence
is
a
cell
state
triggered
by
programmed
physiological
processes
or
cellular
stress
responses.
Stress-induced
senescent
cells
often
acquire
pathogenic
traits,
including
toxic
secretome
and
resistance
to
apoptosis.
When
form
faster
than
they
are
cleared
the
immune
system,
accumulate
in
tissues
throughout
body
contribute
age-related
diseases,
neurodegeneration.
This
review
highlights
evidence
of
brain
their
role
Alzheimer's
disease
(AD),
leading
cause
dementia
older
adults.
We
also
discuss
progress
challenges
senotherapies,
pharmacological
strategies
clear
mitigate
effects,
which
hold
promise
as
interventions
for
AD
related
dementias
(ADRD).
Pharmaceutical Biology,
Год журнала:
2025,
Номер
63(1), С. 89 - 109
Опубликована: Фев. 1, 2025
The
advent
of
tissue
engineering
and
biomedical
techniques
has
significantly
advanced
the
development
three-dimensional
(3D)
cell
culture
systems,
particularly
tumor
organoids.
These
self-assembled
3D
clusters
closely
replicate
histopathological,
genetic,
phenotypic
characteristics
primary
tissues,
making
them
invaluable
tools
in
cancer
research
drug
screening.
This
review
addresses
challenges
developing
vitro
models
that
accurately
reflect
heterogeneity
explores
application
organoids
research,
with
a
specific
focus
on
screening
natural
products
for
antitumor
therapies.
synthesizes
information
from
major
databases,
including
Chemical
Abstracts,
Medicinal
Aromatic
Plants
ScienceDirect,
Google
Scholar,
Scopus,
PubMed
Springer
Link.
Publications
were
selected
without
date
restrictions,
using
terms
such
as
'organoid',
'natural
product',
'pharmacological',
'extract',
'nanomaterial'
'traditional
uses'.
Articles
related
to
agriculture,
ecology,
synthetic
work
or
published
languages
other
than
English
excluded.
identifies
key
efficiency
variability
organoid
generation
discusses
ongoing
efforts
enhance
their
predictive
capabilities
personalized
medicine.
Recent
studies
utilizing
patient-derived
compound
are
highlighted,
demonstrating
potential
these
new
classes
anticancer
agents.
integration
presents
promising
approach
discovering
novel
compounds
elucidating
mechanisms
action.
Journal of Complementary and Integrative Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Abstract
Fisetin,
a
flavonol
belonging
to
the
flavonoid
subclass,
is
ubiquitous
dietary
present
in
fruits
and
vegetables,
including
fruit
peels,
has
proven
potential
for
anticancer
activity,
especially
lung
cancer
–
leading
cause
of
cancer-related
deaths
globally.
The
current
paper
provides
most
detailed
elaborate
list
various
roles
fisetin
experimentally
induced
cells,
these
include
promotion
apoptosis,
inhibition
cell
proliferation,
migration,
invasion,
as
well
regulation
autophagy.
Among
molecular
targets,
some
identified
pathways,
such
PI3K/Akt,
MAPK,
NF-κB,
that
affects
are
crucial
tumor
formation,
so
it
can
be
considered
chemopreventive
agent.
Moreover,
improves
effectiveness
conventional
treatments
chemo-
radiosensitizer
minimizes
side
effects.
However,
overall
utility
clinical
use
now
somewhat
restricted
by
its
poor
solubility
short
half-life.
It
predicted
future
development
nanotechnologies
drug
delivery,
nanoparticle
encapsulation,
might
help
solve
difficulties.
Further
Preclinical
investigations
required
uniformly
determine
safety,
efficacy,
standard
dosage
consumption
therapy.
