Protein–protein interactions regulating α-synuclein pathology

Trends in Neurosciences, Год журнала: 2024, Номер 47(3), С. 209 - 226

Опубликована: Фев. 13, 2024

Язык: Английский

---

Molecular cross-talk between long COVID-19 and Alzheimer’s disease

GeroScience, Год журнала: 2024, Номер 46(3), С. 2885 - 2899

Опубликована: Фев. 23, 2024

Abstract The long COVID (coronavirus disease), a multisystemic condition following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, is one of the widespread problems. Some its symptoms affect nervous system and resemble Alzheimer’s disease (AD)—a neurodegenerative caused by accumulation amyloid beta hyperphosphorylation tau proteins. Multiple studies have found dependence between these two conditions. Patients with greater risk SARS-CoV-2 infection due to increased levels angiotensin-converting enzyme 2 (ACE2), itself promotes generation which enhances AD. Also, molecular pathways are alike—misregulations in folate-mediated one-carbon metabolism, deficit Cq10, disease-associated microglia. Medical imaging both diseases shows decrease volume gray matter, global brain size reduction, hypometabolism parahippocampal gyrus, thalamus, cingulate cortex. In some studies, similar approach applied medication can be seen, including use amino adamantanes phenolic compounds rosemary. significance connections their possible application medical practice still needs further study but there possibility that they will help better understand COVID.

Язык: Английский

---

The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need

Aging and Disease, Год журнала: 2024, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2024

Neurodegenerative diseases, particularly Alzheimer's disease and other dementias as well Parkinson's disease, are emerging profoundly significant challenges burdens to global health, a trend highlighted by the most recent Global Burden of Disease (GBD) 2021 studies. This growing impact is closely linked demographic shift toward an aging population potential long-term repercussions COVID-19 pandemic, both which have intensified prevalence severity these conditions. In this review, we explore several critical aspects complex issue, including increasing burden neurodegenerative unmet medical social needs within current care systems, unique amplified posed strategies for enhancing healthcare policy practice. We underscore urgent need cohesive, multidisciplinary approaches across medical, research, domains effectively address thereby improving quality life patients their caregivers.

Язык: Английский

---

A potential association between COVID-19 vaccination and development of Alzheimer’s disease

QJM, Год журнала: 2024, Номер 117(10), С. 709 - 716

Опубликована: Май 26, 2024

Abstract Background The challenges of the COVID-19 pandemic extend to concerns about vaccine side effects, particularly potential links neurodegenerative diseases such as Alzheimer’s disease (AD). Aim This study investigates association between vaccination and onset AD its prodromal state, mild cognitive impairment (MCI). Design A nationwide, retrospective cohort leveraging data from Korean National Health Insurance Service was conducted. Methods study, conducted in Seoul, South Korea, analyzed a random 50% sample city residents aged 65 above, totaling 558 017 individuals. Participants were divided into vaccinated unvaccinated groups, with vaccinations including mRNA cDNA vaccines. focused on MCI incidences post-vaccination, identified via ICD-10 codes, using multivariable logistic Cox regression analyses. Patients vascular dementia or Parkinson’s served controls. Results Findings showed an increased incidence individuals, those receiving vaccines, within three months post-vaccination. group exhibited significantly higher (odds ratio [OR]: 1.225; 95% confidence interval [CI]: 1.025–1.464; P = 0.026) (OR: 2.377; CI: 1.845–3.064; < 0.001) compared group. No significant relationship found disease. Conclusions Preliminary evidence suggests link vaccination, MCI. warrants need for further research elucidate vaccine-induced immune responses processes, advocating continuous monitoring investigation vaccines' long-term neurological impacts.

Язык: Английский

---

Neurologic Manifestations of Long COVID Disproportionately Affect Young and Middle‐Age Adults

Annals of Neurology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Objective To investigate neurologic manifestations of post‐acute sequelae SARS‐CoV‐2 infection (Neuro‐PASC) in post‐hospitalization Neuro‐PASC (PNP) and non‐hospitalized (NNP) patients across the adult lifespan. Methods Cross‐sectional study first consecutive 200 PNP 1,100 NNP evaluated at a Neuro‐coronavirus disease 2019 (COVID‐19) clinic between May 2020 March 2023. Patients were divided into younger (18–44 years), middle‐age (45–64 older (65+ years) age groups. Results Younger individuals accounted for 142 (71%) 995 1100 (90.5%) patients. Significant age‐related differences frequencies comorbidities abnormal findings demonstrated higher prevalence Conversely, 10 months from COVID‐19 onset, we found significant symptoms indicating lower prevalence, therefore, symptom burden, individuals. Moreover, there subjective impression fatigue (median [interquartile range (IQR)] patient‐reported outcomes measurement information system [PROMIS] score: 64 [57–69], 63 [57–68], 60.5 [50.8–68.3]; p = 0.04) sleep disturbance [IQR] PROMIS 57 [51–63], 56 [53–63], 54 [46.8–58]; 0.002) group, commensurate with impairment quality life (QoL) among Finally, objective executive function National Institutes Health [NIH] toolbox 48 [35–63], 49 [38–63], 54.5 [45–66.3]; 0.01), working memory NIH 47 [40–53], 50 [44–57], [43–58]; 0.0002) patients, worst performance coming group. Interpretation are disproportionally affected by regardless acute severity. Although people more frequently have comorbidities, suffer burden cognitive dysfunction contributing to decreased QoL. principally affects adults their prime, profound public health socioeconomic impacts warranting dedicated resources prevention, diagnosis interventions. ANN NEUROL 2024

Язык: Английский

---

The impact of COVID-19 on autoimmune diseases

Progress in molecular biology and translational science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

---

Structural and Functional Impacts of SARS-CoV-2 Spike Protein Mutations: Insights from Predictive Modeling and Analytics (Preprint)

Опубликована: Март 8, 2025

The COVID-19 pandemic requires a deep understanding of SARS-CoV-2, particularly how mutations in the Spike Receptor Binding Domain (RBD) Chain E affect its structure and function. Current methods lack comprehensive analysis these at different structural levels. To analyze impact specific associated point (N501Y, L452R, N440K, K417N, E484A) on SARS-CoV-2 RBD function using predictive modeling, including graph-theoretic model, protein modeling techniques, molecular dynamics simulations. study employed multi-tiered framework to represent across three interconnected This model incorporated 19 top-level vertices, connected intermediate graphs based 6-angstrom proximity within protein's 3D structure. Graph-theoretic metrics were applied weigh vertices edges all also used Iterative Threading Assembly Refinement (I-TASSER) mutated sequences dynamic simulation (MD) tools evaluate changes folding stability compared wildtype. Three distinct analytical approaches successfully identified functional (Chain E) resulting from mutations. novel detected notable changes, with N501Y L452R showing most pronounced effects conformation stability. K147N E484A demonstrated less significant impacts. Ab initio MD findings corroborated analysis. multi-level approach provided visualization mutation effects, deepening our their consequences. advanced implications. multi-faceted characterized various mutations, identifying as having substantial have important implications for vaccine development, therapeutic design, variant monitoring. research underscores power combining multiple virology, contributing valuable knowledge ongoing efforts against providing future studies viral impacts

Язык: Английский

---

Advances in dopamine electrochemical sensors: Properties and application prospects of different modified materials

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113535 - 113535

Опубликована: Апрель 1, 2025

Язык: Английский

---

Genetic variants in TMPRSS2 influence SARS-CoV-2 infection susceptibility within Mexican Mestizos

Frontiers in Genetics, Год журнала: 2025, Номер 16

Опубликована: Апрель 14, 2025

Since host genetics is one of the primary factors contributing to COVID-19 susceptibility and its clinical progression, several studies have focused on analysing implications genetic polymorphisms associated with COVID-19. These particularly emphasise common variants in genes that are involved viral mechanism entry host’s response infection. In this study, we explored participation 24 single nucleotide located ACE , ADAM17 FURIN IFITM3 TMPRSS2 VDR SARS-CoV-2 infection susceptibility. Three these SNPs (rs75603675, OR = 1.86, 95% CI 1.29–2.66, p ≤ 0.001; rs4303795, 1.98, 1.38–2.84, 0.001 rs8134378, 2.59, 1.28–5.21, 0.01) had a significant association an increased risk When comparing haplotype frequency distributions, haplotypes CAG (OR 7.34, 5.51–9.77), AGA 2.46, 1.12–5.44), AGG 1.59, 1.17–2.16) presented associations, suggesting influences within Mexican Mestizos. alleles their were found more frequently case group than reference group, at least twofold increase infection, finding was reinforced by meta-analyses.

Язык: Английский

---

Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition

Journal of the Neurological Sciences, Год журнала: 2023, Номер 454, С. 120827 - 120827

Опубликована: Окт. 13, 2023

Язык: Английский

---