International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7221 - 7221
Опубликована: Июнь 29, 2024
Decades
of
research
have
identified
genetic
and
environmental
factors
involved
in
age-related
neurodegenerative
diseases
and,
to
a
lesser
extent,
neuropsychiatric
disorders.
Genomic
instability,
i.e.,
the
loss
genome
integrity,
is
common
feature
among
both
(mayo-trophic
lateral
sclerosis,
Parkinson's
disease,
Alzheimer's
disease)
psychiatric
(schizophrenia,
autism,
bipolar
depression)
instability
associated
with
accumulation
persistent
DNA
damage
activation
response
(DDR)
pathways,
as
well
pathologic
neuronal
cell
or
senescence.
Typically,
DDR
signaling
ensures
that
genomic
proteomic
homeostasis
are
maintained
dividing
cells,
including
neural
progenitors,
post-mitotic
neurons.
However,
dysregulation
these
protective
responses,
part
due
aging
insults,
contributes
progressive
development
and/or
In
this
Special
Issue,
we
introduce
highlight
overlap
between
disorders,
emerging
clinical,
genomic,
molecular
evidence
for
contributions
aberrant
repair.
Our
goal
illuminate
importance
subject
uncover
possible
treatment
prevention
strategies
relevant
devastating
brain
diseases.
Frontiers in Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Ноя. 16, 2023
Alzheimer’s
disease
(AD)
is
the
most
common
form
of
dementia.
AD
a
progressive
neurodegenerative
disorder
characterized
by
cognitive
dysfunction,
including
learning
and
memory
deficits,
behavioral
changes.
Neuropathology
hallmarks
such
as
amyloid
beta
(Aβ)
plaques
neurofibrillary
tangles
containing
neuron-specific
protein
tau
associated
with
changes
in
fluid
biomarkers
Aβ,
phosphorylated
(p-tau)-181,
p-tau
231,
217,
glial
fibrillary
acidic
(GFAP),
neurofilament
light
(NFL).
Another
pathological
feature
neural
damage
hyperactivation
astrocytes,
that
can
cause
increased
pro-inflammatory
mediators
oxidative
stress.
In
addition,
reduced
brain
glucose
metabolism
mitochondrial
dysfunction
appears
up
to
15
years
before
onset
clinical
symptoms.
As
utilization
compromised
patients
AD,
ketone
bodies
(KBs)
may
serve
an
alternative
source
energy.
KBs
are
generated
from
β-oxidation
fatty
acids,
which
enhanced
following
consumption
ketogenic
diets
high
fat,
moderate
protein,
low
carbohydrate.
have
been
shown
cross
blood
barrier
improve
energy
metabolism.
This
review
comprehensively
summarizes
current
literature
on
how
increasing
support
for
first
time,
this
discusses
effects
diet
putative
(mainly
181),
GFAP,
NFL,
role
neuroinflammation,
stress,
Cancers,
Год журнала:
2024,
Номер
16(3), С. 510 - 510
Опубликована: Янв. 24, 2024
Pigment
epithelium-derived
factor
(PEDF)
is
a
natural
immunomodulator,
anti-inflammatory,
anti-angiogenic,
anti-tumour
growth
and
anti-metastasis
factor,
which
can
enhance
tumour
response
to
PEDF
but
also
conversely
have
pro-cancerous
effects.
Inflammation
major
cause
of
cancer,
it
has
been
proven
that
anti-inflammatory
properties.
PEDF’s
functional
activity
be
investigated
through
measuring
metastatic
metabolic
biomarkers
will
discussed
in
this
review.
Journal of Dairy Science,
Год журнала:
2024,
Номер
107(10), С. 7564 - 7577
Опубликована: Май 31, 2024
Oxidative
stress
is
a
crucial
factor
in
the
age-related
decline
physiological,
genomic,
metabolic,
and
immunological
functions.
We
screened
Lactiplantibacillus
plantarum
JS19,
which
has
been
shown
to
possess
therapeutic
properties
mice
with
ulcerative
colitis.
In
this
study,
L.
JS19
used
as
adjunct
starter
culture
fermented
goat
milk
(LAF)
was
employed
alleviate
d-galactose-induced
aging
regulate
intestinal
flora
an
mouse
model.
The
oral
administration
of
LAF
effectively
improved
health
spleen
kidney
mice,
while
mitigating
hepatocyte
oxidative
damage
induced
by
d-galactose.
Additionally,
alleviated
dysbiosis
reducing
abundance
harmful
bacteria
Desulfovibrio
Helicobacter,
greatly
promoting
growth
beneficial
Rikenellaceae_RC9_gut_group
Eubacterium.
Biomarker
5-hydroxyindole-3-acetic
acid
found
be
positively
linked
those
bacteria,
whereas
bio-active
metabolites
were
strongly
correlated
genus.
These
observations
suggest
that
possesses
capability
mitigate
effects
model
through
regulation
stress,
gut
microbiota
composition,
levels
fecal
metabolites.
Consequently,
these
findings
shed
light
on
potential
functional
food
antiaging
properties.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7221 - 7221
Опубликована: Июнь 29, 2024
Decades
of
research
have
identified
genetic
and
environmental
factors
involved
in
age-related
neurodegenerative
diseases
and,
to
a
lesser
extent,
neuropsychiatric
disorders.
Genomic
instability,
i.e.,
the
loss
genome
integrity,
is
common
feature
among
both
(mayo-trophic
lateral
sclerosis,
Parkinson's
disease,
Alzheimer's
disease)
psychiatric
(schizophrenia,
autism,
bipolar
depression)
instability
associated
with
accumulation
persistent
DNA
damage
activation
response
(DDR)
pathways,
as
well
pathologic
neuronal
cell
or
senescence.
Typically,
DDR
signaling
ensures
that
genomic
proteomic
homeostasis
are
maintained
dividing
cells,
including
neural
progenitors,
post-mitotic
neurons.
However,
dysregulation
these
protective
responses,
part
due
aging
insults,
contributes
progressive
development
and/or
In
this
Special
Issue,
we
introduce
highlight
overlap
between
disorders,
emerging
clinical,
genomic,
molecular
evidence
for
contributions
aberrant
repair.
Our
goal
illuminate
importance
subject
uncover
possible
treatment
prevention
strategies
relevant
devastating
brain
diseases.
