Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease

Gut Microbes, Год журнала: 2021, Номер 13(1)

Опубликована: Янв. 1, 2021

Clostridium butyricum is a butyrate-producing human gut symbiont that has been safely used as probiotic for decades. C. strains have investigated potential protective or ameliorative effects in wide range of diseases, including gut-acquired infection, intestinal injury, irritable bowel syndrome, inflammatory disease, neurodegenerative metabolic and colorectal cancer. In this review we summarize the studies on supplementation with special attention to proposed mechanisms associated health benefits supporting experimental evidence. These center molecular signals (especially butyrate) well immunological digestive system cascade beyond liver, adipose tissue, brain, more. The safety appears well-established. We identify areas where additional randomized controlled trials would provide valuable further data related strains' utility an intervention.

Язык: Английский

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Gut firmicutes: Relationship with dietary fiber and role in host homeostasis

Critical Reviews in Food Science and Nutrition, Год журнала: 2022, Номер 63(33), С. 12073 - 12088

Опубликована: Июль 12, 2022

Firmicutes and Bacteroidetes are the predominant bacterial phyla colonizing healthy human gut. Accumulating evidence suggests that dietary fiber plays a crucial role in host health, yet most studies have focused on how affects health through gut Bacteroides. More recently, been found to possess many genes responsible for fermenting fiber, could also interact with intestinal mucosa thereby contribute homeostasis. Consequently, relationship between is of interest, as well health. In this review, we summarize current knowledge regarding molecular mechanism degradation by explain communication pathway fiber-Firmicutes-host axis, beneficial effects fiber-induced their metabolites A better understanding dialogue sustained fiber-Firmicutes axis provide new insights into probiotic therapy novel interventions aimed at increasing abundance (such Faecalibacterium, Lactobacillus, Roseburia) promote health.Dietary exhibit relevant health-promoting functions.Most great effect Firmicutes.Mechanisms uptake outlined.Mechanisms fiber- Firmicutes-host interactions require more investigation development food production

Язык: Английский

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Pediococcus pentosaceus, a future additive or probiotic candidate

Microbial Cell Factories, Год журнала: 2021, Номер 20(1)

Опубликована: Фев. 16, 2021

Abstract Background Pediococcus pentosaceus , a promising strain of lactic acid bacteria (LAB), is gradually attracting attention, leading to rapid increase in experimental research. Due increased demand for practical applications microbes, the functional and harmless P. might be worthwhile LAB both food industry biological applications. Results As an additive, improves taste nutrition food, as well storage animal products. Moreover, antimicrobial abilities strains are being highlighted. Evidence suggests that bacteriocins or bacteriocin-like substances (BLISs) produced by play effective antibacterial roles microbial ecosystem. In addition, various have been highlighted probiotic use due their anti-inflammation, anticancer, antioxidant, detoxification, lipid-lowering abilities. Conclusions Therefore, it necessary continue studying further use. Thorough study several should clarify benefits drawbacks future.

Язык: Английский

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Probiotics in the dairy industry—Advances and opportunities

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2021, Номер 20(4), С. 3937 - 3982

Опубликована: Май 3, 2021

Abstract The past two decades have witnessed a global surge in the application of probiotics as functional ingredients food, animal feed, and pharmaceutical products. Among food industries, dairy industry is largest sector where are employed number products including sour/fermented milk, yogurt, cheese, butter/cream, ice cream, infant formula. These either used starter culture alone or combination with traditional starters, incorporated into following fermentation, their presence imparts many characteristics to product (for instance, improved aroma, taste, textural characteristics), addition conferring health‐promoting properties. However, there still challenges related stability functionality This review highlights advances, opportunities, industries. Benefits imparted by role physicochemical nutritional properties (clinical perspective) also discussed. We transcend concept discuss paraprobiotics postbiotics newly emerged field particular relation industry. Some potential applications for development briefly elucidated.

Язык: Английский

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Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis

Bone Research, Год журнала: 2023, Номер 11(1)

Опубликована: Июнь 9, 2023

The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being of host. Recent studies have demonstrated that GM may significantly influence bone metabolism degenerative skeletal diseases, such as osteoporosis (OP). Interventions targeting modification, including probiotics or antibiotics, been found to affect remodeling. This review provides comprehensive summary recent research on regulating remodeling seeks elucidate regulatory mechanism from various perspectives, interaction with immune system, interplay estrogen parathyroid hormone (PTH), impact metabolites, effect extracellular vesicles (EVs). Moreover, this explores potential therapeutic approach for OP. insights presented contribute development innovative GM-targeted therapies

Язык: Английский

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Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients

Cell Host & Microbe, Год журнала: 2023, Номер 31(2), С. 273 - 287.e5

Опубликована: Фев. 1, 2023

Язык: Английский

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Clostridium butyricum and carbohydrate active enzymes contribute to the reduced fat deposition in pigs

iMeta, Год журнала: 2024, Номер 3(1)

Опубликована: Янв. 3, 2024

Pig gastrointestinal tracts harbor a heterogeneous and dynamic ecosystem populated with trillions of microbes, enhancing the ability host to harvest energy from dietary carbohydrates contributing adipogenesis fatness. However, microbial community structure related mechanisms responsible for differences between fatty phenotypes lean pigs remained be comprehensively elucidated. Herein, we first found significant in composition potential functional capacity among different gut locations Jinhua distinct fatness phenotypes. Second, identified that lower exhibited higher levels short-chain acids colon, highlighting their enhanced carbohydrate fermentation capacity. Third, explored expressed carbohydrate-active enzyme (CAZyme) pigs, indicating involvement modulating fat storage. Notably,

Язык: Английский

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Effects of almond (Armeniaca Sibirica L. Lam) polysaccharides on gut microbiota and anti-inflammatory effects on LPS-induced RAW264.7 cells

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 263, С. 130098 - 130098

Опубликована: Фев. 9, 2024

Язык: Английский

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Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behavior

Translational Psychiatry, Год журнала: 2021, Номер 11(1)

Опубликована: Окт. 1, 2021

Abstract The gut microbiome has been speculated to modulate feeding behavior through multiple factors, including short-chain fatty acids (SCFA). Evidence on this relationship in humans is however lacking. We aimed explore if specific bacterial genera relate eating behavior, diet, and SCFA adults. Moreover, we tested whether eating-related microbiota treatment success patients after Roux-en-Y gastric bypass (RYGB). Anthropometrics, dietary fiber intake, 16S-rRNA-derived microbiota, fecal serum were correlated young overweight adults ( n = 27 (9 F), 21–36 years, BMI 25–31 kg/m 2 ). Correlated compared RYGB 23 (16 41–70 25–62 ) control 17 (11 26–69 25–48 In adults, 7 bacteria genera, i.e., Alistipes, Blautia, Clostridiales cluster XVIII, Gemmiger, Roseburia, Ruminococcus, Streptococcus, with healthier while 5 IV XIVb, Collinsella, Fusicatenibacter, Parabacteroides, unhealthier (all | r > 0.4, FDR-corrected p < 0.05). Some of these Parabacteroides related intake SCFA, weight status response overweight/obese patients. exploratory analysis, particularly associated two small, independent well-characterized cross-sectional samples. These preliminary findings suggest groups presumably beneficial unfavorable that status, indicate metabolism may modify relationships. Larger interventional studies are needed distinguish correlation from causation.

Язык: Английский

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Animal-Origin Prebiotics Based on Chitin: An Alternative for the Future? A Critical Review

Foods, Год журнала: 2020, Номер 9(6), С. 782 - 782

Опубликована: Июнь 12, 2020

The human gut microbiota has been revealed in recent years as a factor that plays decisive role the maintenance of health, well development many non-communicable diseases. This can be modulated by various dietary factors, among which complex carbohydrates have great influence. Although most included diet come from vegetables, there are also options to include non-vegetable sources, such chitin and its derivatives. Chitin, derivatives chitosan obtained best being insects, crustacean exoskeletons fungi. present review offers broad perspective current knowledge surrounding impacts derived polysaccharides on profound need for more in-depth investigations into this topic. Overall, effects whole insects or meal contradictory results, possibly due their high protein content. Better results case derivatives, regarding both metabolic composition.

Язык: Английский

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