Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders

Nutrients, Год журнала: 2021, Номер 13(6), С. 2099 - 2099

Опубликована: Июнь 19, 2021

Emerging evidence indicates that gut microbiota is important in the regulation of brain activity and cognitive functions. Microbes mediate communication among metabolic, peripheral immune, central nervous systems via microbiota–gut–brain axis. However, it not well understood how microbiome neurons mutually interact or these interactions affect normal functioning cognition. We summarize mechanisms whereby regulate production, transportation, neurotransmitters. also discuss dysbiosis affects function, especially neurodegenerative diseases such as Alzheimer’s disease Parkinson’s disease.

Язык: Английский

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Gut Microbiota Interact With the Brain Through Systemic Chronic Inflammation: Implications on Neuroinflammation, Neurodegeneration, and Aging

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Апрель 7, 2022

It has been noticed in recent years that the unfavorable effects of gut microbiota could exhaust host vigor and life, yet knowledge theory are just beginning to be established. Increasing documentation suggests microbiota–gut–brain axis not only impacts brain cognition psychiatric symptoms but also precipitates neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS). How blood–brain barrier (BBB), a machinery protecting central nervous system (CNS) from systemic circulation, allows risky factors derived translocated into seems paradoxical. For unique anatomical, histological, immunological properties underpinning its permeable dynamics, BBB regarded biomarker associated with neural pathogenesis. The permeability mice rats caused by GM dysbiosis raises question how metabolites change causes pathophysiology neuroinflammation neurodegeneration (NF&ND) aging, pivotal multidisciplinary field tightly immune chronic inflammation. If all, microbiota-induced inflammation (GM-SCI) mainly refers excessive mucosal immunity dysregulation, which is often influenced dietary components age, produced at interface intestinal (IB) or exacerbated after IB disruption, initiates various common diseases along dispersal routes, eventually impairs integrity cause NF&ND aging. To illustrate roles affected inflammatory “leaky” resulting their metabolites, we reviewed selected publications, including role barrier, influences on permeability, NF&ND, add depth bridging inflammation, plausible mechanism indispensable for corruption was highlighted; namely, maintenance cues cytokines, may help understand play major

Язык: Английский

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Bacterial extracellular vesicles as bioactive nanocarriers for drug delivery: Advances and perspectives

Bioactive Materials, Год журнала: 2021, Номер 14, С. 169 - 181

Опубликована: Дек. 17, 2021

Nanosized extracellular vesicles derived from bacteria contain diverse cargo and transfer intercellular bioactive molecules to cells. Due their favorable interactions, cell membrane-derived bacterial (BEVs) have great potential become novel drug delivery platforms. In this review, we summarize the biogenesis mechanism compositions of various BEVs. addition, an overview effective isolation purification techniques BEVs is provided. particular, focus on application as nanocarriers for delivery. Finally, advances challenges after providing a comprehensive discussion in each section. We believe that deeper understanding will open new avenues exploitation applications.

Язык: Английский

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Vagus Nerve and Underlying Impact on the Gut Microbiota-Brain Axis in Behavior and Neurodegenerative Diseases

Journal of Inflammation Research, Год журнала: 2022, Номер Volume 15, С. 6213 - 6230

Опубликована: Ноя. 1, 2022

Abstract: The gut microbiota is the most abundant and diverse in human body vagus nerve widely distributed complex body, both of them are essential maintaining homeostasis. important phenomenon how they coordinate to regulate functions, which has attracted great attention scientists. academic literature on correlation with a host intestinal diseases even systemic revealed bidirectional communication between brain, can be carried out via multiple patterns. In review, firstly, we have general overview microbiota-brain axis. Secondly, according distribution characteristics nerve, analyzed summarized its function tract. At same time, underlying mechanism some behavior changes such as depressive anxiety-like behaviors related neurodegenerative caused by microecological environment disorders, then also inconsistency experimental evidence order propose novel strategies for clinical practice. Keywords: axis, microbiota, behavior,

Язык: Английский

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The gut microbiome and mental health: advances in research and emerging priorities

Molecular Psychiatry, Год журнала: 2022, Номер 27(4), С. 1908 - 1919

Опубликована: Март 2, 2022

Язык: Английский

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Helicobacter pylori‐derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3‐C3aR signalling

Journal of Extracellular Vesicles, Год журнала: 2023, Номер 12(2)

Опубликована: Фев. 1, 2023

Abstract The gut microbiota represents a diverse and dynamic population of microorganisms that can influence the health host. Increasing evidence supports role as key player in pathogenesis neurodegenerative diseases, including Alzheimer's disease (AD). Unfortunately, mechanisms behind interplay between pathogens AD are still elusive. It is known bacteria‐derived outer membrane vesicles (OMVs) act natural carriers virulence factors central players bacteria. Helicobacter pylori ( H. ) common gastric pathogen infection has been associated with an increased risk to develop AD. Here, we first shed light on OMVs derived from brain healthy conditions pathology case Our results reveal cross biological barriers, eventually reaching brain. Once brain, these taken up by astrocytes, which induce activation glial cells neuronal dysfunction, ultimately leading exacerbated amyloid‐β cognitive decline. Mechanistically, identified critical for complement component 3 (C3)‐C3a receptor (C3aR) signalling mediating interaction microglia neurons upon presence OMVs. Taken together, our study reveals detrimental effect functionality accelerates development via C3‐C3aR signalling.

Язык: Английский

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Bacterial extracellular vesicles: an emerging avenue to tackle diseases

Trends in Microbiology, Год журнала: 2023, Номер 31(12), С. 1206 - 1224

Опубликована: Июнь 16, 2023

Язык: Английский

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Gut microbiota regulates blood‐cerebrospinal fluid barrier function and Aβ pathology

The EMBO Journal, Год журнала: 2023, Номер 42(17)

Опубликована: Июль 10, 2023

Abstract Accumulating evidence indicates that gut microbiota dysbiosis is associated with increased blood–brain barrier (BBB) permeability and contributes to Alzheimer's disease (AD) pathogenesis. In contrast, the influence of on blood‐cerebrospinal fluid (CSF) has not yet been studied. Here, we report mice lacking display blood‐CSF disorganized tight junctions (TJs), which can be rescued by recolonization or supplementation short‐chain fatty acids (SCFAs). Our data reveal important only for establishment but also maintenance a barrier. Also, vagus nerve plays an role in this process SCFAs independently tighten Administration App NL‐G‐F improved subcellular localization TJs at barrier, reduced β‐amyloid (Aβ) burden, affected microglial phenotype. Altogether, our results suggest modulating administering might have therapeutic potential AD via tightening maintaining activity Aβ clearance.

Язык: Английский

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Comparison analysis of microbial agent and different compost material on microbial community and nitrogen transformation genes dynamic changes during pig manure compost

Bioresource Technology, Год журнала: 2024, Номер 395, С. 130359 - 130359

Опубликована: Янв. 23, 2024

Язык: Английский

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Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

Translational Neurodegeneration, Год журнала: 2024, Номер 13(1)

Опубликована: Фев. 27, 2024

The aetiologies and origins of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's (PD), amyotrophic lateral sclerosis (ALS) Huntington's (HD), are complex multifaceted. A growing body evidence suggests that the gut microbiome plays crucial roles in development progression diseases. Clinicians have come to realize therapeutics targeting potential halt This narrative review examines alterations AD, PD, ALS HD, highlighting close relationship between brain Processes mediate microbiome-brain communication including immunological, vagus nerve circulatory pathways, evaluated. Furthermore, we summarize for diseases modify its metabolites, diets, probiotics prebiotics, microbial antibacterials faecal transplantation. Finally, current challenges future directions discussed.

Язык: Английский

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