Bacterial Cellulose and Its Applications

Polymers, Год журнала: 2022, Номер 14(6), С. 1080 - 1080

Опубликована: Март 8, 2022

The sharp increase in the use of cellulose seems to be increasing demand wood; much more research related sustainable or alternative materials is necessary as a lot arable land and natural resources unsustainable. In accordance, attention has focused on bacterial new functional material. It possesses three-dimensional, gelatinous structure consisting with mechanical thermal properties. Moreover, while plant-originated composed cellulose, hemi-cellulose, lignin, attributable composition pure nanofiber mesh spun not elimination other components. due its hydrophilic nature caused by binding water, consequently being hydrogel well biocompatibility, it only used medical fields including artificial skin, cartilage, vessel, wound dressing, but also delivery; some products have even been commercialized. addition, widely various technologies food, paper, textile, electronic electrical applications, considered highly versatile green material tremendous potential. However, many efforts conducted for evolution novel sophisticated environmental affinity, which accompany empowerment enhancement specific this review article, we summarized industry status regarding BC contemplated potential BC.

Язык: Английский

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Exosome-based bone-targeting drug delivery alleviates impaired osteoblastic bone formation and bone loss in inflammatory bowel diseases

Cell Reports Medicine, Год журнала: 2023, Номер 4(1), С. 100881 - 100881

Опубликована: Янв. 1, 2023

Systematic bone loss is commonly complicated with inflammatory bowel diseases (IBDs) unclear pathogenesis and uncertain treatment. In experimental colitis mouse models established by dextran sulfate sodium IL-10 knockout induced piroxicam, mass quality are significantly decreased. Colitis mice demonstrate a lower formation rate fewer osteoblasts in femur. Bone marrow mesenchymal stem/stromal cells (BMSCs) from tend to differentiate into adipocytes rather than osteoblasts. Serum patients IBD promotes adipogenesis of human BMSCs. RNA sequencing reveals that downregulates Wnt signaling For treatment, exosomes Golgi glycoprotein 1 inserted could carry agonist accumulate via intravenous administration. They alleviate loss, promote formation, accelerate fracture healing mice. Collectively, BMSC commitment microenvironment contributes quantity be rescued redirecting differentiation toward through bone-targeted drug delivery.

Язык: Английский

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Bone/cartilage targeted hydrogel: Strategies and applications

Bioactive Materials, Год журнала: 2022, Номер 23, С. 156 - 169

Опубликована: Ноя. 11, 2022

The skeletal system is responsible for weight-bearing, organ protection, and movement. Bone diseases caused by trauma, infection, aging can seriously affect a patient's quality of life. targeted biomaterials are suitable the treatment bone diseases. Biomaterials with bone-targeted properties improve drug utilization reduce side effects. A large number micro-nano materials have been developed. However, only few studies addressed hydrogel. size hydrogel makes it difficult to achieve systematic targeting. local still has significant prospects. Molecules in bone/cartilage extracellular matrix cells provide binding sites Drug delivery systems featuring microgels targeting key construction strategy Besides, injectable depot carrying drugs another strategy. In this review, we summarize through application environment, strategies disease applications. We hope article will reference development hydrogels. also could increase awareness materials.

Язык: Английский

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Silk fibroin-based biomaterials for cartilage/osteochondral repair

Theranostics, Год журнала: 2022, Номер 12(11), С. 5103 - 5124

Опубликована: Янв. 1, 2022

Osteoarthritis (OA) is a common joint disease with high disability rate.In addition, OA not only causes great physiological and psychological harm to patients, but also puts pressure on the social healthcare system.Pathologically, disintegration of cartilage lesions subchondral bone are related OA.Currently, tissue engineering, which expected overcome defects existing treatment methods, had lot research in field cartilage/osteochondral repair.Silk fibroin (SF), as natural macromolecular material good biocompatibility, unique mechanical properties, excellent processability degradability, holds potential engineering.Nowadays, SF been prepared into various materials adapt demands repair.SF-based biomaterials can be functionally modified enhance repair performance further.In this review, preparation types, structures, functional modifications SF-based used for summarized discussed.We hope that review will provide reference design development field.

Язык: Английский

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The tremendous biomedical potential of bacterial extracellular vesicles

Trends in biotechnology, Год журнала: 2022, Номер 40(10), С. 1173 - 1194

Опубликована: Май 14, 2022

Язык: Английский

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Targeted and responsive biomaterials in osteoarthritis

Theranostics, Год журнала: 2023, Номер 13(3), С. 931 - 954

Опубликована: Янв. 1, 2023

Osteoarthritis (OA) is a degenerative disease characterized by loss of articular cartilage and chronic inflammation, involving multiple cellular dysfunctions tissue lesions.The non-vascular environment dense matrix in the joints tend to block drug penetration, resulting low bioavailability.There desire develop safer more effective OA therapies meet challenges an aging world population future.Biomaterials have achieved satisfactory results improving targeting, prolonging duration action, achieving precision therapy.This article reviews current basic understanding pathological mechanisms clinical treatment dilemmas OA, summarizes discusses advances for different kinds targeted responsive biomaterials seeking provide new perspectives OA.Subsequently, limitations translation biosafety are analyzed guide development future therapeutic strategies OA.As need medicine rises over time, emerging multifunctional based on targeting controlled release will become irreplaceable part management.

Язык: Английский

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Engineering Extracellular Vesicles as Delivery Systems in Therapeutic Applications

Advanced Science, Год журнала: 2023, Номер 10(17)

Опубликована: Апрель 20, 2023

Extracellular vesicles (EVs) are transport secreted by living cells and released into the extracellular environment. Recent studies have shown that EVs serve as "messengers" in intercellular inter-organismal communication, both normal pathological processes. EVs, natural nanocarriers, can deliver bioactivators therapy with their endogenous properties. This review article describes engineering of sources, isolation method, cargo loading, boosting approach, adjustable targeting EVs. Furthermore, summarizes recent progress made EV-based delivery systems applications, including cancer, cardiovascular diseases, liver, kidney, nervous system COVID-19 emphasizes obstacles challenges therapies possible strategies.

Язык: Английский

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Articular cartilage repair biomaterials: strategies and applications

Materials Today Bio, Год журнала: 2024, Номер 24, С. 100948 - 100948

Опубликована: Янв. 5, 2024

Articular cartilage injury is a frequent worldwide disease, while effective treatment urgently needed. Due to lack of blood vessels and nerves, the ability self-repair limited. Despite availability various clinical treatments, unfavorable prognoses complications remain prevalent. However, advent tissue engineering regenerative medicine has generated considerable interests in using biomaterials for articular repair. Nevertheless, there remains notable scarcity comprehensive reviews that provide an in-depth exploration strategies applications. Herein, we present overview primary bioactive substances from perspective repair cartilage. The include regeneration, substitution, immunization. We comprehensively delineate influence mechanically supportive scaffolds on cellular behavior, shedding light emerging scaffold technologies, including stimuli-responsive smart scaffolds, 3D-printed bionic scaffolds. Biologically active substances, factors, stem cells, extracellular vesicles (EVs), organoids, are elucidated their roles regulating activity chondrocytes. Furthermore, composite produced industrially put into use, also explicitly presented. This review offers innovative solutions treating ailments emphasizes potential translation.

Язык: Английский

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Bone-targeted bioengineered bacterial extracellular vesicles delivering siRNA to ameliorate osteoporosis

Composites Part B Engineering, Год журнала: 2023, Номер 255, С. 110610 - 110610

Опубликована: Фев. 13, 2023

Язык: Английский

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Bone‐Targeted Exosomes: Strategies and Applications

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(18)

Опубликована: Март 7, 2023

Abstract As the global population ages, bone‐related diseases have increasingly become a major social problem threatening human health. Exosomes, as natural cell products, been used to treat due their superior biocompatibility, biological barrier penetration, and therapeutic effects. Moreover, modified exosomes exhibit strong bone‐targeting capabilities that may improve efficacy avoid systemic side effects, demonstrating promising translational potential. However, review of bone‐targeted is still lacking. Thus, recently developed for applications in this are focused. The biogenesis regulatory functions exosomes, constructive strategies bone‐targeting, effects introduced. By summarizing developments challenges It striven shed light on selection exosome different bone highlight potential future clinical orthopedics.

Язык: Английский

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