Journal of Bone and Mineral Metabolism, Год журнала: 2022, Номер 40(6), С. 874 - 889
Опубликована: Ноя. 1, 2022
Язык: Английский
Aging and Disease, Год журнала: 2022, Номер 13(4), С. 1106 - 1106
Опубликована: Янв. 1, 2022
Gut microbiota, a collection of microorganisms that live within gastrointestinal tract, provides crucial signaling metabolites for the physiological hosts. In healthy state, gut microbiota are helpful maintaining basic functions hosts, whereas disturbed production these can lead to numerous diseases such as metabolic diseases, cardiovascular neurodegenerative and cancer. Although there many reviews about specific mechanisms on is no comprehensive summarization metabolites. this Opinion, we discuss knowledge including types their ways acting targets. addition, summarize pathologic in health shaping composition nutrition. This paper be understanding roles thus provide guidance developing suitable therapeutic strategies combat microbial-driven improve health.
Язык: Английский
Процитировано
249
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Фев. 16, 2024
Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management
Язык: Английский
Процитировано
231
Microbiology Insights, Год журнала: 2023, Номер 16
Опубликована: Янв. 1, 2023
Evidence indicates that short-chain fatty acids (SCFAs) generated from the gut microbiota play crucial roles in host metabolism. They contribute to metabolic regulation and energy acquisition of by influencing development disorders. This review aims synthesize recent advances literature investigate implication SCFAs modulation obesity diabetes pathologies. For a better understanding relationships between metabolism, we need answer some questions: What is biochemistry SCFAs, how they are microbiota? bacteria producing which routes? How absorbed transported different mechanisms receptors? involved pathologies?
Язык: Английский
Процитировано
43
Food Chemistry, Год журнала: 2024, Номер 446, С. 138739 - 138739
Опубликована: Фев. 16, 2024
Язык: Английский
Процитировано
18
Journal of Advanced Research, Год журнала: 2022, Номер 53, С. 153 - 173
Опубликована: Дек. 7, 2022
The gut microbiota (GM) and brain are strongly associated, which significantly affects neuronal development disorders. GM-derived metabolites modulate function influence many cascades in age-related neurodegenerative disorders (NDDs). Because of the dual role GM neuroprotection neurodegeneration, understanding balance between beneficial harmful bacteria is crucial for applying this approach to clinical therapies.This review briefly discusses gut-brain relationship promoting cognitive function. Although a healthy environment helpful function, dysbiosis can disrupt brain's create vicious cycle degenerative cascades. ways population affect neurodegeneration also discussed. In treatment management NDDs, effects methods targeting populations their derivatives, including probiotics, prebiotics, fecal microbial transplantation (FMT) highlighted.In review, we aimed provide deeper mechanisms microbe-brain twin roles progression therapeutic applications. Here, attempted highlight different pathways connecting gut, together with development. Furthermore, potential pathogenesis strategies its investigated. By analyzing existing vitro, vivo studies, attempts identify new promising central nervous system (CNS) As connection responses NDD treatments less studied, will insights into global modulation disease progression, future perspectives developing therapies treat NDDs.
Язык: Английский
Процитировано
51
Experimental & Molecular Medicine, Год журнала: 2023, Номер 55(1), С. 55 - 68
Опубликована: Янв. 4, 2023
Gut microbial preparations are widely used in treating intestinal diseases but show mixed success. In this study, we found that the therapeutic efficacy of A. muciniphila for dextran sodium sulfate (DSS)-induced colitis as well radiation toxicity was ~50%, and mice experiencing a positive prognosis harbored high frequency gastrointestinal (GI) tract. Stable GI colonization elicited more profound shifts gut community structure hosts. Coexisting with facilitated proliferation reprogrammed gene expression profile Lactobacillus murinus, classic probiotic overtly responded to addition time-dependent manner. Then, magnetic-drove, mannose-loaded nanophase material designed linked surface muciniphila. The modified exhibited enhancements inflammation targeting under an external magnetic field, elevating positive-response rate against diseases. However, unlinked cocktail containing delivery system only induced negligible improvement efficacy. Importantly, heat-inactivated lost effects on DSS-induced even retained tract long time. Further investigations revealed able drive M2 macrophage polarization by upregulating protein level IL-4 at inflammatory loci. Together, our findings demonstrate stable live lesion sites is essential its anti-inflammatory function.
Язык: Английский
Процитировано
32
mBio, Год журнала: 2023, Номер 15(1)
Опубликована: Дек. 6, 2023
Gut microbiota exert influence on gastrointestinal mucosal permeability, bile acid metabolism, short-chain fatty synthesis, dietary fiber fermentation, and farnesoid X receptor/Takeda G protein-coupled receptor 5 (TGR5) signal transduction. The incretin glucagon-like peptide 1 (GLP-1) is mainly produced by L cells in the gut regulates postprandial blood glucose. Changes composition function have been observed obesity type 2 diabetes (T2D). Meanwhile, rhythm of GLP-1 also affected subjects with or T2D. Therefore, it necessary to discuss link between microbiome GLP-1. In this review, we describe interaction metabolic diseases. On one hand, metabolites stimulate secretion, affect rhythm. other mechanism action involves inflammatory response. Additionally, effects various interventions, such as prebiotics, probiotics, antidiabetic drugs, bariatric surgery, crosstalk Finally, stress that can be used a target for diseases, clinical application agonists should individualized.
Язык: Английский
Процитировано
32
The Science of The Total Environment, Год журнала: 2023, Номер 890, С. 164297 - 164297
Опубликована: Май 20, 2023
Язык: Английский
Процитировано
31
The Innovation, Год журнала: 2023, Номер 4(5), С. 100486 - 100486
Опубликована: Июль 26, 2023
The gut microbiota consistently shows strong correlations with lipid metabolism in humans and animals, whether the contributes to muscle fatty acid (FA) deposition meat traits farm animals has not been fully resolved. In this study, we aimed unveil microbial mechanisms underlying FA pigs. First, systematically revealed correlation between microbiome levels 43 obese Ningxiang pigs 50 lean Duroc Landrace Yorkshire (DLY) Mutual fecal transplantation showed that pig-derived increased content improved quality by reshaping composition DLY Lactobacillus reuteri identified as a potential biomarker microbiota-challenged A gavage experiment using confirmed L. XL0930 isolated from was causal species content. Mechanistically, SLC22A5, carnitine transporter, downregulated XL0930-fed pigs, resulting reduced levels. Muscle intestinal L-carnitine levels, which correlated content, impeded fat synthesis accumulation vitro vivo models. conclusion, uncovered an unexpected important role of regulating via SLC22A5-mediated system.
Язык: Английский
Процитировано
30
Medicina, Год журнала: 2023, Номер 59(3), С. 594 - 594
Опубликована: Март 17, 2023
Metabolic-dysfunction-associated fatty liver disease (MAFLD) is the recent nomenclature designation that associates condition of non-alcoholic (NAFLD) with metabolic dysfunction. Its diagnosis has been debated in period and generally associated a steatosis at least one pathologic among overweight/obesity, type 2 diabetes mellitus, dysregulation. pathogenesis defined by “multiple-hit” model alteration or dysbiosis gut microbiota. The pathogenic role microbiota investigated many diseases, including obesity, NAFLD. However, only few works correlate it MAFLD, although common pathogenetic links to these diseases are suspected. This review underlines most recurrent changes patients while also evidencing possible links.
Язык: Английский
Процитировано
28