Environmental Pollution, Год журнала: 2022, Номер 309, С. 119789 - 119789
Опубликована: Июль 14, 2022
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Фев. 16, 2024
Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management
Язык: Английский
Процитировано
231
Microbiome, Год журнала: 2023, Номер 11(1)
Опубликована: Янв. 31, 2023
Abstract Background Sleep loss is a serious global health concern. Consequences include memory deficits and gastrointestinal dysfunction. Our previous research showed that melatonin can effectively improve cognitive impairment intestinal microbiota disturbances caused by sleep deprivation (SD). The present study further explored the mechanism which exogenous prevents SD-induced impairments. Here, we established fecal transplantation, Aeromonas colonization LPS or butyrate supplementation tests to evaluate role of its metabolites in alleviating impairment. Results Transplantation SD-gut into normal mice induced microglia overactivation neuronal apoptosis hippocampus, decline, colonic disorder, manifesting as increased levels decreased Lachnospiraceae_NK4A136 butyrate. All these events were reversed with transplantation SD + melatonin-gut microbiota. Colonization addition produced an inflammatory response hippocampus spatial mice. These changes melatonin, accompanied LPS. Butyrate administration sleep-deprived restored responses In vitro, BV2 cells, was improved supplementation. This ameliorative effect blocked pretreatment MCT1 inhibitor HDAC3 agonist but mimicked TLR4 p-P65 antagonists. Conclusions Gut microbes their mediate effects on A feasible downregulates constituent upregulates colon. lessen through crosstalk between TLR4/NF-κB MCT1/ signaling pathways.
Язык: Английский
Процитировано
130
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114985 - 114985
Опубликована: Июнь 11, 2023
The gut microbiota is indispensable for maintaining host health by enhancing the host's digestive capacity, safeguarding intestinal epithelial barrier, and preventing pathogen invasion. Additionally, exhibits a bidirectional interaction with immune system promotes of to mature. Dysbiosis microbiota, primarily caused factors such as genetic susceptibility, age, BMI, diet, drug abuse, significant contributor inflammatory diseases. However, mechanisms underlying diseases resulting from dysbiosis lack systematic categorization. In this study, we summarize normal physiological functions symbiotic in healthy state demonstrate that when occurs due various external factors, are lost, leading pathological damage lining, metabolic disorders, barrier damage. This, turn, triggers disorders eventually causes systems. These discoveries provide fresh perspectives on how diagnose treat unrecognized variables might affect link between illnesses need further studies extensive basic clinical research will still be required investigate relationship future.
Язык: Английский
Процитировано
130
Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Июнь 24, 2022
Parkinson’s disease (PD) is the second most common neurodegenerative characterized by motor dysfunction. Growing evidence has demonstrated that gut dysbiosis involved in occurrence, development and progression of PD. Numerous clinical trials have identified characteristics changed microbiota profiles, preclinical studies PD animal models indicated can influence onset via increasing intestinal permeability, aggravating neuroinflammation, aggregating abnormal levels α-synuclein fibrils, oxidative stress, decreasing neurotransmitter production. The be considered promising diagnostic therapeutic targets for PD, which regulated probiotics, psychobiotics, prebiotics, synbiotics, postbiotics, fecal transplantation, diet modifications, Chinese medicine. This review summarizes recent PD-associated profiles functions, potential roles, mechanisms microbiota-targeted interventions Deciphering underlying roles will help interpret pathogenesis from new perspectives elucidate novel strategies
Язык: Английский
Процитировано
107
Microorganisms, Год журнала: 2023, Номер 11(7), С. 1772 - 1772
Опубликована: Июль 7, 2023
Desulfovibrio (DSV) are sulfate-reducing bacteria (SRB) that ubiquitously present in the environment and as resident commensal within human gastrointestinal tract. Though they minor residents of healthy gut, DSV opportunistic pathobionts may overgrow setting various intestinal extra-intestinal diseases. An increasing number studies have demonstrated a positive correlation between overgrowth (bloom) While relationship bloom disease pathology has not been clearly established, mounting evidence suggests causal role for these development. As most predominant genera SRB this review summarizes current knowledge regarding variety In study, we also discuss mechanisms by which contribute to pathology.
Язык: Английский
Процитировано
91
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Дек. 6, 2023
Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and nervous systems. In past few decades, breakthrough progress has been made in gut liver brain axis, mainly through understanding its formation mechanism increasing treatment strategies. this review, we discuss various complex networks including barrier permeability, hormones, microbial metabolites, vagus nerve, neurotransmitters, immunity, toxic β-amyloid (Aβ) metabolism, epigenetic regulation gut-liver-brain axis. Some therapies containing antibiotics, probiotics, prebiotics, synbiotics, fecal microbiota transplantation (FMT), polyphenols, low FODMAP diet nanotechnology application regulate Besides, some special treatments targeting gut-liver include farnesoid X receptor (FXR) agonists, takeda G protein-coupled 5 (TGR5) glucagon-like peptide-1 (GLP-1) antagonists fibroblast growth factor 19 (FGF19) analogs. Targeting gut-brain embraces cognitive behavioral therapy (CBT), antidepressants tryptophan metabolism-related therapies. liver-brain contains Aβ future, better interactions will promote development novel preventative strategies discovery precise therapeutic targets multiple diseases.
Язык: Английский
Процитировано
86
Cell Reports, Год журнала: 2022, Номер 41(8), С. 111681 - 111681
Опубликована: Ноя. 1, 2022
Highlights•Gut dysbiosis contributes to the development of mastitis and mammary dysbiosis•Bacterial translocation is involved in gut-dysbiosis-induced mastitis•Commensal Roseburia alleviates by producing butyrate•Butyrate improves barrier integrity limits bacterial translocationSummaryThe precise mechanism which gut pathogenesis extraintestinal diseases how commensal microbes mediate these processes remain unclear. Here, we show that cows with had marked dysbiosis, characterized enrichment opportunistic pathogenic Escherichia_Shigella depletion Roseburia. Fecal microbiota transplantation from donor (M-FMT) recipient mice significantly caused changed mice. Notably, M-FMT facilitated pathobiont into gland, Enterobacteriaceae alleviated M-FMT-induced In contrast, intestinalis improved microbial gland limited butyrate, was associated inflammatory signaling inhibition repair. Our research suggests mastitis, although further studies dairy humans are needed.Graphical abstract
Язык: Английский
Процитировано
73
Seminars in Immunology, Год журнала: 2023, Номер 69, С. 101802 - 101802
Опубликована: Июль 7, 2023
The multifaceted microbiota characterizing our gut plays a crucial role in maintaining immune, metabolic and tissue homeostasis of the intestine as well distal organs, including central nervous system. Microbial dysbiosis is reported several inflammatory intestinal diseases characterized by impairment epithelial vascular barriers, defined leaky gut, it potential danger condition associated with development metabolic, neurodegenerative diseases. Recently, we pointed out strict connection between brain via novel axis. Here want to deepen knowledge on gut-brain axis, particular emphasis microbial dysbiosis, cerebral firm association axis will be summarized context protection, amelioration or boosting Alzheimer, Parkinson, Major depressive Anxiety disorders. Understanding relationship disease pathophysiology, mucosal barrier function host-microbe interaction foster use microbiome biomarker for health target therapeutic nutritional advances.
Язык: Английский
Процитировано
59
Translational Neurodegeneration, Год журнала: 2023, Номер 12(1)
Опубликована: Дек. 15, 2023
Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases. The typical symptomatology PD includes motor symptoms; however, a range nonmotor symptoms, such as intestinal issues, usually occur before symptoms. Various microorganisms inhabiting gastrointestinal tract can profoundly influence physiopathology central nervous system through neurological, endocrine, and immune pathways involved in microbiota-gut-brain axis. In addition, extensive evidence suggests that gut microbiota strongly associated with PD. This review summarizes latest findings on microbial changes their clinical relevance, describes underlying mechanisms which bacteria may mediate PD, discusses correlations between microbes anti-PD drugs. this outlines status research therapies for future directions PD-gut research.
Язык: Английский
Процитировано
47
Ageing Research Reviews, Год журнала: 2024, Номер 94, С. 102196 - 102196
Опубликована: Янв. 12, 2024
Язык: Английский
Процитировано
40