Aging and Disease,
Год журнала:
2024,
Номер
15(1), С. 74 - 74
Опубликована: Янв. 1, 2024
Amyotrophic
Lateral
Sclerosis
(ALS)
is
a
devastating
neurodegenerative
disease
which
strongly
associated
with
age.
The
incidence
of
ALS
increases
from
the
age
40
and
peaks
between
ages
65
70.
Most
patients
die
respiratory
muscle
paralysis
or
lung
infections
within
three
to
five
years
appearance
symptoms,
dealing
huge
blow
their
families.
With
aging
populations,
improved
diagnostic
methods
changes
in
reporting
criteria,
likely
show
an
upward
trend
coming
decades.
Despite
extensive
researches
have
been
done,
cause
pathogenesis
remains
unclear.
In
recent
decades,
large
quantities
studies
focusing
on
gut
microbiota
shown
that
its
metabolites
seem
change
evolvement
through
brain-gut-microbiota
axis,
turn,
progression
will
exacerbate
imbalance
microbiota,
thereby
forming
vicious
cycle.
This
suggests
further
exploration
identification
function
may
be
crucial
break
bottleneck
diagnosis
treatment
this
disease.
Hence,
current
review
summarizes
discusses
latest
research
advancement
future
directions
so
as
help
relevant
researchers
gain
correlative
information
instantly.
Abstract
Background
Aging
is
a
natural
process
that
an
organism
gradually
loses
its
physical
fitness
and
functionality.
Great
efforts
have
been
made
to
understand
intervene
in
this
deteriorating
process.
The
gut
microbiota
affects
host
physiology,
dysbiosis
of
the
microbial
community
often
underlies
pathogenesis
disorders.
commensal
also
changes
with
aging;
however,
interplay
between
aging
remains
largely
unexplored.
Here,
we
systematically
examined
ameliorating
effects
derived
from
young
on
physiology
phenotypes
aged.
Results
As
fecal
was
transplanted
mice
at
5
weeks
after
birth
into
12-month-old
ones,
thickness
muscle
fiber
grip
strength
were
increased,
water
retention
ability
skin
enhanced
thickened
stratum
corneum.
Muscle
marginally
increased
25-month-old
transferring
young.
Bacteria
enriched
received
young-derived
significantly
correlated
improved
altered
gene
expression.
In
dermis
these
mice,
transcription
Dbn1
most
upregulated
DBN1-expressing
cells
twice.
-heterozygous
exhibited
impaired
barrier
function
hydration.
Conclusions
We
revealed
rejuvenates
aged
by
altering
composition
expression
skin.
,
for
first
time,
found
be
induced
modulate
Our
results
provide
solid
evidence
improves
vitality
Current Opinion in Neurobiology,
Год журнала:
2022,
Номер
78, С. 102652 - 102652
Опубликована: Дек. 1, 2022
There
is
growing
appreciation
of
key
roles
the
gut
microbiota
in
maintaining
homeostasis
and
influencing
brain
behaviour
at
critical
windows
across
lifespan.
Mounting
evidence
suggests
that
communication
between
could
be
to
understanding
multiple
neuropsychiatric
disorders,
with
immune
system
coming
forefront
as
an
important
mechanistic
mediator.
Throughout
lifespan,
exchanges
continuous
reciprocal
signals
central
nervous
system.
Intestinal
microbial
cues
alter
mediators
consequences
for
host
neurophysiology
behaviour.
Several
factors
challenge
composition,
which
response
release
molecules
neuro-
immuno-active
potential
are
crucial
adequate
neuro-immune
interactions.
In
this
review,
contributing
upkeep
fine
balance
health
disease
these
systems
discussed,
we
elucidate
implications
inputs
on
In
recent
years,
the
improvement
in
health
and
social
conditions
has
led
to
an
increase
average
lifespan.
Since
aging
is
most
important
risk
factor
for
majority
of
chronic
human
diseases,
development
therapies
intervention
stop,
lessen
or
even
reverse
various
age-related
morbidities
target
ameliorate
quality
life
elderly.
The
gut
microbiota,
that
is,
complex
ecosystem
microorganisms
living
gastrointestinal
tract,
plays
role,
not
yet
fully
understood,
maintaining
host’s
homeostasis,
influencing
metabolic,
oxidative
cognitive
status;
this
reason,
it
also
named
“the
forgotten
endocrine
organ”
second
brain”.
On
other
hand,
microbiota
diversity
richness
are
affected
by
unmodifiable
factors,
such
as
sex,
modifiable
ones,
diet,
pharmacological
lifestyle.
review,
we
discuss
changes,
mostly
disadvantageous,
health,
induced
aging,
composition
effects
dietary
intervention,
supplementation
with
probiotics,
prebiotics,
synbiotics,
psychobiotics
antioxidants
physical
exercise.
integrated
strategy
implement
will
help
goal
healthy
aging.
Cold Spring Harbor Perspectives in Medicine,
Год журнала:
2023,
Номер
14(6), С. a041197 - a041197
Опубликована: Дек. 5, 2023
Amit
Singh1,6,
Shepherd
H.
Schurman2,6,
Arsun
Bektas3,
Mary
Kaileh1,
Roshni
Roy1,5,
David
M.
Wilson
III4,
Ranjan
Sen1
and
Luigi
Ferrucci3
1Laboratory
of
Molecular
Biology
Immunology,
National
Institute
on
Aging,
Baltimore,
Maryland
21224,
USA
2Clinical
Research
Unit,
3Translational
Gerontology
Branch,
4Biomedical
Institute,
Hasselt
University,
Diepenbeek
3500,
Belgium
Correspondence:
ferruccilu{at}grc.nia.nih.gov
↵6
These
authors
contributed
equally
to
this
work.
↵5
Present
address:
Department
Microbiology
Emory
University
School
Medicine,
Atlanta,
Georgia
30322,
USA.
Intestinal
epithelial
cells
(IECs)
serve
as
both
a
physical
and
an
antimicrobial
barrier
against
the
microbiota,
well
conduit
for
signaling
between
microbiota
systemic
host
immunity.
As
individuals
age,
balance
these
systems
undergoes
myriad
of
changes
due
to
age-associated
IECs
themselves,
immunosenescence,
inflammaging.
In
this
review,
we
discuss
emerging
data
related
loss
intestinal
integrity
posit
that
IEC
dysfunction
may
play
central
role
in
propagating
alterations
composition
immune
homeostasis.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Окт. 27, 2022
Retinitis
pigmentosa
(RP)
is
an
important
cause
of
irreversible
blindness
worldwide
and
lacks
effective
treatment
strategies.
Although
mutations
are
the
primary
RP,
research
over
past
decades
has
shown
that
neuroinflammation
RP
progression.
Due
to
abnormal
activation
immunity,
continuous
sterile
inflammation
results
in
neuron
loss
structural
destruction.
Therapies
targeting
have
their
potential
attenuate
photoreceptor
degeneration
preclinical
models.
Regardless
variations
genetic
background,
inflammatory
modulation
emerging
as
role
RP.
We
summarize
evidence
for
mention
therapeutic
strategies
where
available,
focusing
on
innate
immune
signals,
including
TNFα
signaling,
TLR
NLRP3
inflammasome
activation,
chemokine
signaling
JAK/STAT
signaling.
In
addition,
we
describe
epigenetic
regulation,
gut
microbiome
herbal
agents
prospective
recent
advances.
International Journal of Oral Science,
Год журнала:
2023,
Номер
15(1)
Опубликована: Янв. 12, 2023
Periodontitis
is
the
most
widespread
oral
disease
and
closely
related
to
microbiota.
The
microbiota
adversely
affected
by
some
pharmacologic
treatments.
Systemic
antibiotics
are
widely
used
for
infectious
diseases
but
can
lead
gut
dysbiosis,
causing
negative
effects
on
human
body.
Whether
systemic
antibiotic-induced
dysbiosis
affect
or
even
periodontitis
has
not
yet
been
addressed.
In
this
research,
mice
were
exposed
drinking
water
containing
a
cocktail
of
four
explore
how
pathogenicity
bone
loss.
results
demonstrated,
first
time,
that
caused
long-term
use
disturb
aggravate
periodontitis.
Moreover,
expression
cytokines
Th17
was
increased
while
transcription
factors
Treg
decreased
in
periodontal
tissue.
Fecal
transplantation
with
normal
feces
restored
barrier,
microbiota,
reversed
Th17/Treg
imbalance
tissue,
alleviated
alveolar
This
study
highlights
potential
adverse
antibiotics-induced
A
might
be
relationship.
Importantly,
these
reveal
condition
patients
should
assessed
regularly
when
using
clinical
practice.
Nutrients,
Год журнала:
2023,
Номер
15(8), С. 1802 - 1802
Опубликована: Апрель 7, 2023
A
decline
in
muscle
mass
and
function
represents
one
of
the
most
problematic
changes
associated
with
aging,
has
dramatic
effects
on
autonomy
quality
life.
Several
factors
contribute
to
inexorable
process
sarcopenia,
such
as
mitochondrial
autophagy
dysfunction,
lack
regeneration
capacity
satellite
cells.
The
physiologic
motoneuron
functionality
aging
is
exacerbated
by
sedentary
lifestyle
that
accompanies
elderly
people.
Regular
physical
activity
beneficial
people,
but
need
well-designed
carefully
administered
training
programs
improve
and,
consequently,
both
functional
ability
Aging
also
causes
alteration
gut
microbiota
composition
some
advances
research
have
elucidated
interventions
via
microbiota–muscle
axis
potential
ameliorate
sarcopenic
phenotype.
mechanisms
are
involved
vitamin
D
atrophy
protection,
demonstrated
decreased
muscular
related
deficiency.
Malnutrition,
chronic
inflammation,
deficiencies,
an
imbalance
muscle–gut
just
a
few
can
lead
sarcopenia.
Supplementing
diet
antioxidants,
polyunsaturated
fatty
acids,
vitamins,
probiotics,
prebiotics,
proteins,
kefir,
short-chain
acids
could
be
nutritional
therapies
against
Finally,
personalized
integrated
strategy
counteract
sarcopenia
maintain
health
skeletal
muscles
suggested
this
review.
