Colon
cancer
affects
people
of
all
ages.
However,
its
frequency,
as
well
the
related
morbidity
and
mortality,
are
high
among
older
adults.
The
complex
physiological
changes
in
aging
gut
substantially
limit
development
therapies.
Here,
we
identify
a
unique
intestinal
microenvironment
that
is
linked
with
an
increased
risk
colon
Our
findings
show
markedly
influences
persistent
fucosylation
apical
surfaces
epithelial
cells,
which
results
favorable
environment
for
tumor
growth.
Furthermore,
our
shed
light
on
importance
host-commensal
interaction,
facilitates
dysregulation
promotes
growth
get
older.
We
analyzed
colonic
microbial
populations
at
species
level
to
find
associated
could
contribute
cancer.
Analysis
scRNAseq
from
previous
publication
datasets
identifies
distinct
cell
subtypes
involved
dysregulated
Overall,
study
provides
compelling
evidence
excessive
cancer,
age-related
increase
vulnerability
dysbiosis
diversity
metabolic
homeostasis
mice
dysregulate
levels
age.
Journal of Advanced Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 1, 2024
Population
aging
has
become
a
primary
global
public
health
issue,
and
the
prevention
of
age-associated
diseases
prolonging
healthy
life
expectancies
are
particular
importance.
Gut
microbiota
emerged
as
novel
target
in
various
host
physiological
disorders
including
aging.
Comprehensive
understanding
on
changes
gut
during
aging,
characteristics
centenarians,
can
provide
us
possibility
to
achieving
or
intervene
pathological
through
microbiota-directed
strategies.
This
review
aims
summarize
associated
with
explore
potential
biomarkers
address
microbiota-associated
mechanisms
focusing
intestinal
barrier
immune
status.
By
summarizing
existing
effective
dietary
strategies
interventions,
probability
developing
diet
targeting
future
is
provided.
focused
three
key
notions:
Firstly,
new
for
regulating
status
lifespan,
its
closely
related
age.
Thus,
we
summarized
aging-associated
features
at
levels
genus/species
important
metabolites
comparing
differences
among
elderly
people
younger
people.
Secondly,
exploring
discussing
using
regime/components
targeted
aging-related
promote
human
lifespan.
Thirdly,
intervention
effectively
improve
imbalance
such
probiotics,
prebiotics,
postbiotics,
but
their
effects
vary
among.
Intestinal
epithelial
cells
(IECs)
serve
as
both
a
physical
and
an
antimicrobial
barrier
against
the
microbiota,
well
conduit
for
signaling
between
microbiota
systemic
host
immunity.
As
individuals
age,
balance
these
systems
undergoes
myriad
of
changes
due
to
age-associated
IECs
themselves,
immunosenescence,
inflammaging.
In
this
review,
we
discuss
emerging
data
related
loss
intestinal
integrity
posit
that
IEC
dysfunction
may
play
central
role
in
propagating
alterations
composition
immune
homeostasis.
Aging Clinical and Experimental Research,
Год журнала:
2024,
Номер
36(1)
Опубликована: Март 6, 2024
Age-related
changes
in
intestinal
microbiome
composition
and
function
are
increasingly
recognized
as
pivotal
the
pathophysiology
of
aging
associated
with
phenotype.
Diet
is
a
major
determinant
gut-microbiota
throughout
entire
lifespan,
several
benefits
healthy
diet
could
be
mediated
by
microbiome.
Mediterranean
(MD)
traditional
dietary
pattern
regarded
paradigm,
large
number
studies
have
demonstrated
its
promoting
aging.
MD
has
also
positive
modulatory
effect
on
microbiome,
favoring
bacterial
taxa
involved
synthesis
bioactive
compounds,
such
short-chain
fatty
acids
(SCFAs),
that
counteract
inflammation,
anabolic
resistance,
tissue
degeneration.
Intervention
conducted
older
populations
suggested
individual
response
subjects
to
MD,
terms
reduction
frailty
scores
amelioration
cognitive
function,
significantly
functionality.
In
this
context,
should
considered
when
designing
MD-based
interventions
tailored
needs
geriatric
patients.
Abstract
The
intricate
interplay
between
cellular
senescence
and
alterations
in
the
gut
microbiome
emerges
as
a
pivotal
axis
aging
process,
increasingly
recognized
for
its
contribution
to
systemic
inflammation,
physiological
decline,
predisposition
age‐associated
diseases.
Cellular
senescence,
characterized
by
cessation
of
cell
division
response
various
stressors,
induces
morphological
functional
changes
within
tissues.
complexity
heterogeneity
senescent
cells,
alongside
secretion
senescence‐associated
secretory
phenotype,
exacerbate
process
through
pro‐inflammatory
pathways
influence
microenvironment
immune
system.
Concurrently,
aging‐associated
diversity
composition
contribute
dysbiosis,
further
exacerbating
inflammation
undermining
integrity
bodily
functions.
This
review
encapsulates
burgeoning
research
on
reciprocal
relationship
highlighting
their
collective
impact
age‐related
musculoskeletal
diseases,
including
osteoporosis,
sarcopenia,
osteoarthritis.
It
also
explores
potential
modulating
targeting
innovative
strategies
healthy
mitigating
progression
aging‐related
conditions.
By
exploring
targeted
interventions,
development
senotherapeutic
drugs
probiotic
therapies,
this
aims
shed
light
novel
therapeutic
avenues.
These
leverage
connection
advance
interventions
aimed
at
extending
health
span
improving
quality
life
older
population.
Ageing Research Reviews,
Год журнала:
2023,
Номер
91, С. 102083 - 102083
Опубликована: Окт. 5, 2023
Cellular
senescence
is
a
pivotal
factor
contributing
to
aging
and
the
pathophysiology
of
age-related
diseases.
Despite
presence
inflammation
abnormal
immune
system
function
in
both
inflammatory
bowel
diseases
(IBD)
senescence,
relationship
between
two
remains
largely
unexplored.
Therefore,
our
study
aimed
investigate
intricate
connection
cellular
telomeres,
IBD.
The
review
highlights
markers,
particularly
p16
p21,
IBD
patients,
suggesting
their
potential
association
with
disease
progression
mucosal
inflammation.
We
emphasize
critical
role
macrophages
eliminating
senescent
cells
how
disturbance
effective
clearance
may
contribute
persistent
Additionally,
we
shed
light
on
involvement
telomeres
IBD,
as
dysfunction
impairs
enterocyte
disrupts
colonic
barrier
integrity,
potentially
exacerbating
pathogenesis
disease.
Targeting
telomere
dysfunctions
holds
promise
for
development
innovative
therapeutic
approaches
mitigate
intestinal
alleviate
symptoms
patients.
By
unraveling
precise
can
pave
way
discovery
novel
interventions
that
effectively
address
underlying
mechanisms
inflammation,
offering
hope
improved
management
treatment
Abstract
Background
The
characterization
and
research
around
the
gut
microbiome
in
older
people
emphasize
microbial
populations
change
considerably
by
losing
diversity
of
species.
Then,
this
review
aims
to
determine
if
there
is
any
effect
on
microbiota
adults
than
65
that
starts
an
exercise
intervention
or
improves
physical
activity
level.
Also,
describes
changes
composition,
diversity,
function
subjects
had
improved
their
Methods
type
studies
included
were
describing
human
responses
stimulus;
cross-sectional
focused
comparing
with
different
levels—from
athletes
inactive
individuals;
containing
(women
men),
written
English.
This
review's
primary
outcomes
interest
abundance
diversity.
Results
Twelve
three
randomized
controlled
trials
examined.
Independently
study,
metrics
from
Alpha
Beta
remained
without
almost
all
studies.
Likewise,
do
not
reflect
significant
diversity;
no
differences
detected
among
diverse
groups
relative
abundances
major
phyla
alpha
measures.
Otherwise,
analysis
showed
a
who
conducted
program
for
five
weeks
more
at
genus
Conclusions
Here,
we
did
identify
shifts
metrics;
only
one
study
reported
difference
overweight
higher
levels.
some
bacteria
aged
people,
after
program,
comparison
control
groups,
especially
species
There
needs
be
information
related
metabolic
pathways
can
crucial
understand
adults.
Trial
registration
PROSPERO
ID:
CRD42022331551.
Advances in Nutrition,
Год журнала:
2024,
Номер
15(8), С. 100263 - 100263
Опубликована: Июнь 17, 2024
The
increasing
prevalence
of
noncommunicable
diseases
in
the
aging
population
has
been
correlated
with
a
decline
innate
and
adaptive
immune
responses;
hence,
it
is
imperative
to
identify
approaches
improve
function,
prevent
related
disorders,
reduce
or
treat
age-associated
health
complications.
Prebiotic
supplementation
promising
approach
modulate
gut
microbiome
system,
offering
potential
strategy
maintain
integrity
function
older
individuals.
This
review
summarizes
current
research
on
prebiotic
galacto-oligosaccharide
(GOS)
immunomodulatory
mechanisms
mediated
by
bacterial-derived
metabolites,
including
short-chain
fatty
acids
secondary
bile
acids,
homeostasis.
applications
GOS
as
immunotherapy
for
age-related
disease
prevention
individuals
are
also
highlighted.
aligns
global
shift
toward
proactive
healthcare
emphasizes
significance
early
intervention
directing
an
individual's
trajectory.
Abstract
Background
Alterations
in
the
composition
and
function
of
intestinal
microbiota
have
been
observed
organismal
aging
across
a
broad
spectrum
animal
phyla.
Recent
findings,
which
derived
mostly
simple
models,
even
established
causal
relationship
between
age-related
microbial
shifts
lifespan,
suggesting
microbiota-directed
interventions
as
potential
tool
to
decelerate
processes.
To
test
whether
life-long
microbiome
rejuvenation
strategy
could
delay
or
prevent
non-ruminant
mammals,
we
performed
recurrent
fecal
transfer
(FMT)
mice
throughout
life.
Transfer
material
was
either
from
8-week-old
(young
microbiome,
yMB)
animals
same
age
recipients
(isochronic
iMB)
control.
Motor
coordination
strength
were
analyzed
by
rotarod
grip
tests,
barrier
serum
LAL
assay,
transcriptional
responses
single-cell
RNA
sequencing,
community
properties
16S
rRNA
gene
profiling
metagenomics.
Results
Colonization
with
yMB
improved
permeability
compared
iMB.
encoded
fewer
pro-inflammatory
factors
altered
metabolic
pathways
favoring
oxidative
phosphorylation.
Ecological
interactions
among
bacteria
more
antagonistic
than
iMB
implying
stable
communities.
Single-cell
sequencing
analysis
mucosa
revealed
salient
shift
cellular
phenotypes
group
markedly
increased
ATP
synthesis
mitochondrial
well
decrease
age-dependent
mesenchymal
hallmark
transcripts
enterocytes
TA
cells,
but
reduced
inflammatory
signaling
macrophages.
Conclusions
Taken
together,
demonstrate
that
repeated
young
processes
including
coordinative
ability
(rotarod),
permeability,
both
profiles
mainly
macrophages
also
other
immune
cells.
