The gut microbiota in obesity and weight management: microbes as friends or foe?

Nature Reviews Endocrinology, Год журнала: 2023, Номер 19(5), С. 258 - 271

Опубликована: Янв. 17, 2023

Язык: Английский

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Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures

Nature Aging, Год журнала: 2023, Номер 3(4), С. 436 - 449

Опубликована: Апрель 6, 2023

Язык: Английский

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Succinate metabolism and its regulation of host-microbe interactions

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Март 22, 2023

Succinate is a circulating metabolite, and the relationship between abnormal changes in physiological concentration of succinate inflammatory diseases caused by overreaction certain immune cells has become research focus. Recent investigations have shown that produced gut microbiota potential to regulate host homeostasis treat such as inflammation. Gut microbes are important for maintaining intestinal homeostasis. Microbial metabolites serve nutrients energy metabolism, act signal molecules stimulate cell organ function affect structural balance symbiotic microorganisms. This review focuses on metabolite both its involvement regulating – tissue axis activating mucosal cells, including macrophages, dendritic epithelial cells. We also examined role mediator crosstalk explores feasible ways moderate levels provides new insights into target microbial therapeutics humans.

Язык: Английский

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The Role of Next-Generation Probiotics in Obesity and Obesity-Associated Disorders: Current Knowledge and Future Perspectives

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6755 - 6755

Опубликована: Апрель 4, 2023

Obesity and obesity-associated disorders pose a major public health issue worldwide. Apart from conventional weight loss drugs, next-generation probiotics (NGPs) seem to be very promising as potential preventive therapeutic agents against obesity. Candidate NGPs such Akkermansia muciniphila, Faecalibacterium prausnitzii, Anaerobutyricum hallii, Bacteroides uniformis, coprocola, Parabacteroides distasonis, goldsteinii, Hafnia alvei, Odoribacter laneus Christensenella minuta have shown promise in preclinical models of obesity disorders. Proposed mechanisms include the modulation gut flora amelioration intestinal dysbiosis, improvement barrier function, reduction chronic low-grade inflammation peptide secretion. muciniphila alvei already been administered overweight/obese patients with encouraging results. However, safety issues strict regulations should constantly implemented updated. In this review, we aim explore (1) current knowledge regarding NGPs; (2) their utility disorders; (3) profile; (4) individuals overweight/obesity. More large-scale, multicentric longitudinal studies are mandatory its related

Язык: Английский

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Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity

Cell Reports Medicine, Год журнала: 2023, Номер 4(12), С. 101341 - 101341

Опубликована: Дек. 1, 2023

The gut microbiota contributes to the pathophysiology of non-alcoholic fatty liver disease (NAFLD). Histidine is a key energy source for microbiota, scavenging it from host. Its role in NAFLD poorly known. Plasma metabolomics, transcriptomics, and fecal metagenomics were performed three human cohorts coupled with hepatocyte, rodent, Drosophila models. Machine learning analyses identified plasma histidine as being strongly inversely associated steatosis linked hepatic transcriptomic signature involved insulin signaling, inflammation, trace amine-associated receptor 1. Circulating was Proteobacteria positively bacteria lacking utilization (Hut) system. supplementation improved different animal models (diet-induced mouse flies, ob/ob mouse, ovariectomized rats) reduced de novo lipogenesis. Fecal transplantation (FMT) low-histidine donors mono-colonization germ-free flies Enterobacter cloacae increased triglyceride accumulation content. interplay among catabolism, opens therapeutic opportunities.

Язык: Английский

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Stachyose in combination with L. rhamnosus GG ameliorates acute hypobaric hypoxia-induced intestinal barrier dysfunction through alleviating inflammatory response and oxidative stress

Free Radical Biology and Medicine, Год журнала: 2024, Номер 212, С. 505 - 519

Опубликована: Янв. 9, 2024

Язык: Английский

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Alterations in gut and genital microbiota associated with gynecological diseases: a systematic review and meta-analysis

Reproductive Biology and Endocrinology, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 18, 2024

Abstract Background Increasing number of studies have demonstrated certain patterns microbial changes in gynecological diseases; however, the interaction between them remains unclear. To evaluate consistency or specificity across multiple on different diseases and alterations at sites body (gut genital tract), we conducted a systematic review meta-analysis. Methods We searched PubMed, Embase, Web Science, Cochrane Library up to December 5, 2022(PROSPERO: CRD42023400205). Eligible focused adult women, applied next-generation sequencing microbiome, reported outcomes including alpha beta diversity relative abundance. The random-effects model standardized mean difference (SMD) was using inverse-variance method for indices. Results Of 3327 unique articles, 87 eligible were included. Significant decreases found gut microbiome patients versus controls (observed species SMD=-0.35; 95%CI, -0.62 -0.09; Shannon index SMD=-0.23; -0.40 -0.06), whereas significant increases observed vaginal (Chao1 SMD = 1.15; 0.74 1.56; 0.51; 0.16 0.86). Most diagnostic categories showed no differences diversity. Disease observed, but almost all only replicated three studies, except increased Aerococcus bacterial vaginosis (BV). Patients with major shared enrichment Prevotella depletion Lactobacillus , an overlap microbes implied BV, cervical intraepithelial neoplasia, cancer. Conclusions These findings association microbiota diseases. most results rather than disease-specific alterations. Therefore, further investigation is required identify specific biomarkers diagnosis treatment future.

Язык: Английский

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Identification of an epilepsy-linked gut microbiota signature in a pediatric rat model of acquired epilepsy

Neurobiology of Disease, Год журнала: 2024, Номер 194, С. 106469 - 106469

Опубликована: Март 13, 2024

A dysfunctional gut microbiota-brain axis is emerging as a potential pathogenic mechanism in epilepsy, particularly pediatric forms of epilepsy. To add new insights into gut-related changes acquired epilepsy that develops early life, we used multi-omics approach rat model with 56% incidence The presence spontaneous seizures was assessed adult rats (n = 46) 5 months after status epilepticus induced by intra-amygdala kainate at postnatal day 13, 2 weeks (24/7) ECoG monitoring. Twenty-six developed (Epi) while the remaining 20 (No-Epi) did not show seizures. At end monitoring, all and their sham controls 20) were sacrificed for quantitative histopathological immunohistochemical analyses structure, glia macrophages, well RTqPCR analysis inflammation/oxidative stress markers. By comparing Epi, No-Epi rats, controls, found structural, cellular, molecular alterations reflecting gut, which specifically associated In particular, villus height-to-crypt depth ratio number Goblet cells reduced duodenum Epi vs both (p < 0.01). Villus height crypt jejunum 0.01) increased controls. We also detected enhanced Iba1-positive together IL1b NFE2L2 transcripts TNF protein, small intestine control 0.01), denoting inflammation oxidative stress. Astroglial GFAP-immunostaining similar experimental groups. Metagenomic feces collected showed two dominant phyla (Bacteroidota-to-Firmicutes) similarly rats. Notably, relative abundance families, genera species SCFA production differed describing bacterial imprint Furthermore, blood metabolic signature characterized lipid metabolism compared to Our study provides evidence long-term alterations, along microbiota-related changes, occurring develop brain injury life.

Язык: Английский

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Effects of Salmonella Typhimurium infection on intestinal flora and intestinal tissue arachidonic acid metabolism in Wenchang chickens

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Янв. 24, 2025

Salmonella infections can lead to intestinal inflammation and metabolic disorders in birds. However, whether arachidonic acid (ARA) metabolism is involved -induced remains unclear. This experiment investigated the changes cecal flora ARA Hainan Wenchang chickens infected with S. Typhimurium using 16s rDNA sequencing targeted metabolomics. The results showed that levels of metabolites were increased cecum tissue after infection , including prostaglandin E2 (PGE 2 ), F2α (PGF 2α lipoxin A4 (LXA4), ± 8(9)-EET, 11(12)-EET, 8,9-DiHETrE. content key enzymes for production (Phospholipase A2 PLA2 Cyclooxygenase-2 COX-2) chicken tissues was infection. relative mRNA inflammatory factors also infection, Interferon-γ (IFN-γ), Transforming growth factor-β1 (TGF-β1), Interleukin-4 (IL-4), Interleukin-6 (IL-6). In HD11 cells, use a cyclooxygenase (COX) inhibitor reduced COX-2 PGF induced by effectively response. addition, number beneficial genera (e.g., Bifidobacterium Lactobacillus Odorobacterium ) significantly . present study revealed structure -infected chickens. this demonstrated activates pathway, which turn mediates development provide data support theoretical prevention control avian salmonellosis.

Язык: Английский

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2,5-dimethylcelecoxib alleviated NK and T-cell exhaustion in hepatocellular carcinoma via the gastrointestinal microbiota-AMPK-mTOR axis

Journal for ImmunoTherapy of Cancer, Год журнала: 2023, Номер 11(6), С. e006817 - e006817

Опубликована: Июнь 1, 2023

2,5-dimethylcelecoxib (DMC), a derivative of celecoxib, is an inhibitor microsomal prostaglandin E synthase-1 (mPGES-1). Our previous studies have demonstrated that DMC inhibits the expression programmed death-ligand 1 on hepatocellular carcinoma (HCC) cells to prevent tumor progression. However, effect and mechanism HCC infiltrating immune remain unclear. In this study, single-cell-based high-dimensional mass cytometry was performed microenvironment mice treated with DMC, celecoxib MK-886 (a known mPGES-1 inhibitor). Moreover, 16S ribosomal RNA sequencing employed analyze how improved by remodeling gastrointestinal microflora. We found (1) significantly inhibited growth prognosis mice, depended stronger antitumor activity natural killer (NK) T cells; (2) compared MK-886, enhanced cytotoxic stem-like potential, exhaustion NK (3) mechanistically, cell death protein-1 upregulated interferon-γ via microbiota (Bacteroides acidifaciens, Odoribacter laneus, splanchnicus)-AMPK-mTOR axis. study uncovers role in improving HCC, which not only enriches relationship between mPGES-1/prostaglandin E2 pathway function cells, but also provide important strategic reference for multitarget or combined immunotherapy HCC.Cite Now.

Язык: Английский

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