Polymers,
Год журнала:
2022,
Номер
14(8), С. 1611 - 1611
Опубликована: Апрель 15, 2022
Many
infections
are
associated
with
the
use
of
implantable
medical
devices.
The
excessive
utilization
antibiotic
treatment
has
resulted
in
development
antimicrobial
resistance.
Consequently,
scientists
have
recently
focused
on
conceiving
new
ways
for
treating
a
longer
duration
action
and
minimum
environmental
toxicity.
One
approach
infection
control
is
based
coatings
polymers
peptides,
also
termed
as
“natural
antibiotics”.
Military Medical Research,
Год журнала:
2021,
Номер
8(1)
Опубликована: Сен. 9, 2021
Abstract
The
management
of
bacterial
infections
is
becoming
a
major
clinical
challenge
due
to
the
rapid
evolution
antibiotic
resistant
bacteria.
As
an
excellent
candidate
overcome
resistance,
antimicrobial
peptides
(AMPs)
that
are
produced
from
synthetic
and
natural
sources
demonstrate
broad-spectrum
activity
with
high
specificity
low
toxicity.
These
possess
distinctive
structures
functions
by
employing
sophisticated
mechanisms
action.
This
comprehensive
review
provides
broad
overview
AMPs
origin,
structural
characteristics,
action,
biological
activities
applications.
We
finally
discuss
strategies
optimize
develop
AMP-based
treatment
as
potential
anticancer
therapeutics.
Molecules,
Год журнала:
2022,
Номер
27(9), С. 2675 - 2675
Опубликована: Апрель 21, 2022
Antimicrobial
peptides
are
a
type
of
small-molecule
peptide
that
widely
exist
in
nature
and
components
the
innate
immunity
almost
all
living
things.
They
play
an
important
role
resisting
foreign
invading
microorganisms.
have
wide
range
antibacterial
activities
against
bacteria,
fungi,
viruses
other
active
traditional
antibiotic-resistant
strains
do
not
easily
induce
development
drug
resistance.
Therefore,
they
become
hot
spot
medical
research
expected
to
new
substitute
for
fighting
microbial
infection
represent
method
treating
drug-resistant
bacteria.
This
review
briefly
introduces
source
structural
characteristics
antimicrobial
describes
those
been
used
common
clinical
microorganisms
(bacteria,
viruses,
especially
coronaviruses),
focusing
on
their
mechanism
action
application
prospects.
Plants,
Год журнала:
2023,
Номер
12(11), С. 2226 - 2226
Опубликована: Июнь 5, 2023
Throughout
evolution,
plants
have
developed
a
highly
complex
defense
system
against
different
threats,
including
phytopathogens.
Plant
depends
on
constitutive
and
induced
factors
combined
as
mechanisms.
These
mechanisms
involve
signaling
network
linking
structural
biochemical
defense.
Antimicrobial
pathogenesis-related
(PR)
proteins
are
examples
of
this
mechanism,
which
can
accumulate
extra-
intracellular
space
after
infection.
However,
despite
their
name,
some
PR
present
at
low
levels
even
in
healthy
plant
tissues.
When
they
face
pathogen,
these
PRs
increase
abundance,
acting
the
first
line
Thus,
play
key
role
early
events,
reduce
damage
mortality
caused
by
pathogens.
In
context,
review
will
discuss
response
proteins,
been
identified
PRs,
with
enzymatic
action,
enzymes,
β-1,3
glucanase,
chitinase,
peroxidase
ribonucleases.
From
technological
perspective,
we
advances
last
decade
applied
to
study
important
events
higher
Antibiotics,
Год журнала:
2022,
Номер
11(3), С. 349 - 349
Опубликована: Март 6, 2022
Infection
of
multidrug-resistant
(MDR)
bacteria,
such
as
methicillin-resistant
Staphylococcus
aureus
(MRSA),
carbapenem-resistant
Enterobacteriaceae
(CRE),
and
extended-spectrum
beta-lactamase
(ESBL)-producing
Escherichia
coli,
brings
public
health
issues
causes
economic
burden.
Pathogenic
bacteria
develop
several
methods
to
resist
antibiotic
killing
or
inhibition,
mutation
function
sites,
activation
drug
efflux
pumps,
enzyme-mediated
degradation.
Antibiotic
resistance
components
can
be
transferred
between
by
mobile
genetic
elements
including
plasmids,
transposons,
integrons,
well
bacteriophages.
The
development
limits
the
treatment
options
for
bacterial
infection,
especially
MDR
bacteria.
Therefore,
novel
alternative
antibacterial
agents
are
urgently
needed.
Antimicrobial
peptides
(AMPs)
display
multiple
mechanisms
against
infections,
directly
bactericidal
activity
immunomodulatory
function,
potential
alternatives
antibiotics.
In
this
review,
resistance,
AMPs,
especially,
design,
optimization,
delivery
AMPs
reviewed.
Strategies
structural
change,
amino
acid
substitution,
conjugation
with
cell-penetration
peptide,
terminal
acetylation
amidation,
encapsulation
nanoparticles
will
improve
antimicrobial
efficacy,
reduce
toxicity,
accomplish
local
AMPs.
addition,
clinical
trials
in
AMP
studies
applications
within
last
five
years
were
summarized.
Overall,
diverse
action
infection
pathogenic
future
research
investigations
accelerate
application.
Advanced Agrochem,
Год журнала:
2023,
Номер
2(1), С. 58 - 78
Опубликована: Янв. 31, 2023
As
important
physiological
regulators,
peptides
have
been
used
in
many
fields
including
medicine,
cosmetics,
healthcare
products,
animal
nutrition
and
health,
plant
protection.
In
recent
years,
become
a
popular
research
subject
protection
as
antimicrobial
immune
inducers,
growth
insecticides,
herbicides
for
their
extensive
raw
material
sources,
excellent
activity,
ideal
environmental
compatibility.
This
paper
briefly
introduces
peptide
progress,
presents
an
overview
of
studies
protection,
summarizes
the
application
prospects
green
agrochemicals.
European Journal of Microbiology and Immunology,
Год журнала:
2024,
Номер
14(2), С. 97 - 115
Опубликована: Апрель 22, 2024
Abstract
Infectious
diseases
pose
a
formidable
global
challenge,
compounded
by
the
emergence
of
antimicrobial
resistance.
Consequently,
researchers
are
actively
exploring
novel
compounds
as
potential
solutions.
This
endeavor
underscores
pivotal
role
methods
employed
for
screening
and
evaluating
activity—a
critical
step
in
discovery
characterization
agents.
While
traditional
techniques
such
well-diffusion,
disk-diffusion,
broth-dilution
commonly
utilized
assays,
they
may
encounter
limitations
concerning
reproducibility
speed.
Additionally,
diverse
array
assays
including
cross-streaking,
poisoned-food,
co-culture,
time-kill
kinetics,
resazurin
assay,
bioautography,
etc.,
routinely
evaluations.
Advanced
flow-cytometry,
impedance
analysis,
bioluminescent
technique
offer
rapid
sensitive
results,
providing
deeper
insights
into
impact
antimicrobials
on
cellular
integrity.
However,
their
higher
cost
limited
accessibility
certain
laboratory
settings
present
challenges.
article
provides
comprehensive
overview
designed
to
characterize
activity,
elucidating
underlying
principles,
protocols,
advantages,
limitations.
The
primary
objective
is
enhance
understanding
methodologies
agents
our
relentless
battle
against
infectious
diseases.
By
selecting
appropriate
testing
method,
can
discern
suitable
conditions
streamline
identification
effective
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
267, С. 131537 - 131537
Опубликована: Апрель 10, 2024
The
growing
demand
for
sustainable
and
eco-friendly
food
packaging
has
prompted
research
on
innovative
solutions
to
environmental
consumer
health
issues.
To
enhance
the
properties
of
smart
packaging,
incorporation
bioactive
compounds
derived
from
various
natural
sources
attracted
considerable
interest
because
their
functional
properties,
including
antioxidant
antimicrobial
effects.
However,
extracting
these
poses
challenges
complex
chemical
structures
low
concentrations.
Traditional
extraction
methods
are
often
environmentally
harmful,
expensive
time-consuming.
Thus,
green
techniques
have
emerged
as
promising
alternatives,
offering
approaches
that
minimise
use
hazardous
solvents
reduce
impact.
This
review
explores
cutting-edge
into
systems
in
last
10
years.
Then,
an
overview
compounds,
techniques,
integrated
application
was
provided,
impact
incorporated
shelf
lives
products
explored.
Furthermore,
it
highlights
opportunities
within
this
field
presents
recommendations
future
research,
aiming
contribute
advancement
efficient
solutions.
Antibiotics,
Год журнала:
2024,
Номер
13(3), С. 202 - 202
Опубликована: Фев. 21, 2024
Antimicrobial
peptides
(AMPs)
are
usually
made
up
of
fewer
than
100
amino
acid
residues.
They
found
in
many
living
organisms
and
an
important
factor
those
organisms’
innate
immune
systems.
AMPs
can
be
extracted
from
various
sources,
including
bacteria,
plants,
animals,
even
humans.
cationic
with
amphiphilic
structure,
which
allows
them
to
easily
bind
interact
the
cellular
membranes
viruses,
fungi,
other
pathogens.
act
against
both
Gram-negative
Gram-positive
pathogens
have
modes
action
them.
Some
attack
pathogens’
membranes,
while
others
target
their
intracellular
organelles,
as
well
nucleic
acids,
proteins,
metabolic
pathways.
A
crucial
area
AMP
use
is
related
ability
help
emerging
antibiotic
resistance:
some
active
resistant
strains
susceptible
peptide
engineering.
This
review
considers
three
key
sources—plants,
humans—as
sequences.
