Protective Role of Melatonin against Liver Toxicity from Black Phosphorus Nanosheets via Oxidative Stress and Pyroptosis DOI Creative Commons
Bo Zhang,

Yuechen Xing,

Yuanyuan Guo

и другие.

ACS Omega, Год журнала: 2024, Номер 9(47), С. 46891 - 46903

Опубликована: Ноя. 11, 2024

In the field of contemporary medicine, with rapid application nanomaterials, evaluating their biocompatibility and potential toxicity has become increasingly important. This study characterized black phosphorus nanosheets (BPNSs) employed both in vivo vitro models to assess impact BPNSs exposure on oxidative stress pyroptosis hepatocytes. We investigated hepatotoxicity this emerging nanomaterial protective role melatonin against induced hepatocyte pyroptosis. The results showed that reduced viability, morphological changes, elevated expression pyroptosis-related proteins, suggesting promote through ROS-NLRP3-GSDMD pathway, thereby exacerbating inflammatory response. Melatonin, a bioactive substance anti-inflammatory antioxidant properties, was found our significantly mitigate these adverse effects. It emphasized regulating ROS production related pathways, effectively protecting hepatocytes from damage. elucidates mechanistic link between pyroptosis, emphasizing efficacy as agent. offers new insights for preventing liver injury provides foundation safer strategies.

Язык: Английский

Pyroptosis in health and disease: mechanisms, regulation and clinical perspective DOI Creative Commons
Yifan Liu,

Renjie Pan,

Yuzhen Ouyang

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 20, 2024

Язык: Английский

Процитировано

33
Dual sources of melatonin and evidence for different primary functions DOI Creative Commons
Russel J. Reıter, Ramaswamy Sharma, Dun‐Xian Tan

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Май 14, 2024

This article discusses data showing that mammals, including humans, have two sources of melatonin exhibit different functions. The best-known source melatonin, herein referred to as Source #1, is the pineal gland. In this organ, production circadian with maximal synthesis and release into blood cerebrospinal fluid occurring during night. Of total amount produced in we speculate less than 5% synthesized by rhythm has primary function influencing clock at level suprachiasmatic nucleus (the CSF melatonin) clockwork all peripheral organs via receptor-mediated actions. A second (Source # 2) from multiple tissues throughout body, probably being mitochondria these cells. constitutes bulk mammals concerned metabolic regulation. review emphasizes action determining re-dox homeostasis, but it other critical effects well. Extrapineal does not a released acts locally its cell origin possibly paracrine matter on adjacent factors control/influence extrapineal sites are unknown. We propose concentration cells determined subcellular redox state may be inducible under stressful conditions plant

Язык: Английский

Процитировано

22
Roles of Sirtuins in Cardiovascular Diseases: Mechanisms and Therapeutics DOI

Yang-Nan Ding,

Hui-Yu Wang,

Xiaofeng Chen

и другие.

Circulation Research, Год журнала: 2025, Номер 136(5), С. 524 - 550

Опубликована: Фев. 27, 2025

Cardiovascular diseases (CVDs) are experiencing a rapid surge and widely recognized as the leading cause of mortality in current aging society. Given multifactorial etiology CVDs, understanding intricate molecular cellular mechanisms is imperative. Over past 2 decades, many scientists have focused on Sirtuins, family nicotinamide adenine dinucleotide–dependent deacylases. Sirtuins highly conserved across species, from yeasts to primates, play crucial role linking diseases. participate nearly all key physiological pathological processes, ranging embryogenic development stress response aging. Abnormal expression activity exist aging-related diseases, while their activation has shown efficacy mitigating these (eg, CVDs). In terms research, this field maintained fast, sustained growth recent years, fundamental studies clinical trials. review, we present comprehensive, up-to-date discussion biological functions roles regulating cardiovascular biology CVDs. Furthermore, highlight latest advancements utilizing Sirtuin-activating compounds dinucleotide boosters potential pharmacological targets for preventing treating The unresolved issues field—from chemicobiological regulation Sirtuin-targeted CVD investigations—are also discussed. This timely review could be critical updated knowledge Sirtuin CVDs facilitating accessibility Sirtuin-targeting interventions.

Язык: Английский

Процитировано

3
Epigenetic regulation of diverse regulated cell death modalities in cardiovascular disease: Insights into necroptosis, pyroptosis, ferroptosis, and cuproptosis DOI Creative Commons
Cong Chen, Jie Wang,

Shan Zhang

и другие.

Redox Biology, Год журнала: 2024, Номер 76, С. 103321 - 103321

Опубликована: Авг. 19, 2024

Cell death constitutes a critical component of the pathophysiology cardiovascular diseases. A growing array non-apoptotic forms regulated cell (RCD)-such as necroptosis, ferroptosis, pyroptosis, and cuproptosis-has been identified is intimately linked to various conditions. These RCD are governed by genetically programmed mechanisms within cell, with epigenetic modifications being common crucial regulatory method. Such include DNA methylation, RNA histone acetylation, non-coding RNAs. This review recaps roles modifications, RNAs in diseases, well which regulate key proteins involved death. Furthermore, we systematically catalog existing pharmacological agents targeting novel their action article aims underscore pivotal role precisely regulating specific pathways thus offering potential new therapeutic avenues that may prove more effective safer than traditional treatments.

Язык: Английский

Процитировано

7
Inhibition of hippocampal melatonin synthesis by siRNA induced learning and memory deficits in male rats DOI

Tahereh Ghorbandaiepour,

Esmaeil Sadroddiny, Maryam Zahmatkesh

и другие.

Hormones and Behavior, Год журнала: 2024, Номер 164, С. 105599 - 105599

Опубликована: Июль 3, 2024

Язык: Английский

Процитировано

4
Roles of SIRT3 in cardiovascular and neurodegenerative diseases DOI
Liang Chen, Anqi Zhao, Ying Li

и другие.

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102654 - 102654

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Melatonin’s Role in Redox Homeostasis: A Preclinical and Clinical Perspective DOI
Flaviene Felix Torres, Victoria Simões Bernardo, Ana Clara Albertin Zucão

и другие.

Pharmacological Research - Natural Products, Год журнала: 2025, Номер unknown, С. 100147 - 100147

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Macrophage Pyroptosis in Atherosclerosis: Therapeutic Potential DOI Creative Commons

Jian-ying Ma,

Yixian Wang, W. Xu

и другие.

Acta Biochimica et Biophysica Sinica, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Atherosclerosis (AS) is a chronic inflammatory disease characterized by the accumulation of lipid-rich plaques in arterial walls, leading to cardiovascular events such as myocardial infarction and stroke. Macrophage pyroptosis, form programmed cell death driven NLRP3 inflammasome caspase-1 activation, plays critical role progression destabilization atherosclerotic plaques. This review explores molecular mechanisms underlying macrophage pyroptosis their significant contributions AS pathogenesis. Recent advancements have highlighted therapeutic potential targeting key components pyroptotic pathway, including use nanotechnology increase drug delivery specificity. These strategies are promising for reducing inflammation, stabilizing plaques, mitigating clinical impact AS. Future studies should focus on translating these findings into applications develop effective treatments that can halt or reverse modulating pyroptosis.

Язык: Английский

Процитировано

0
Lidocaine could promote the cuproptosis through up-regulating the long noncoding RNA DNMBP-AS1 in Hep-2 cells DOI Creative Commons
Wei Liu, Yi Yu, Yi He

и другие.

BMC Cancer, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 22, 2025

Abstract Background Lidocaine is a traditional local anesthetic, which has been reported to trigger apoptosis through the mitochondrial pathway, independent of death receptor signaling. Cuproptosis copper triggered cell mode. In this study, we explored biological effects lidocaine on cuproptosis in Hep-2 cells and studied relevant mechanisms. Methods quantitative RT-PCR was used measure expression level long noncoding RNA (IncRNA) DNMBP-AS1. DNMBP-AS1 siRNA (si-DNMBP-AS1) were transfected into verify roles cuproptosis. 24 h treatment with 20 nM elesclomol 2 µM CuCl performed promote occurrence Cuproptosis. Cell proliferation, migration assays ware utilized analyze effect cells. Active caspase-3 also determined after treatment. Results significantly upregulated during The si-DNMBP-AS1 increased viability nonactivated caspase-3, promoted suppress cytotoxic dose- time-dependent manner. Exposure 10 for did not reduce or activated but DNMBP-AS1, Anymore, reversed pro-cuproptosis function lidocaine. Conclusions time- dose-dependent manner, up-regulating results study offered initial optimism that could be an adjuvant neoadjuvant fashion cancer

Язык: Английский

Процитировано

0
Macrophage pyroptosis and its crucial role in ALI/ARDS DOI Creative Commons

Yuju Cai,

Luorui Shang,

Fangyuan Zhou

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 14, 2025

Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS) is a severe clinical syndrome characterized by high morbidity and mortality, primarily due to injury. However, the pathogenesis of ALI/ARDS remains complex issue. In recent years, role macrophage pyroptosis in injury has garnered extensive attention worldwide. This paper reviews mechanism pyroptosis, discusses its ALI/ARDS, introduces several drugs intervening measures that can regulate influence progression ALI/ARDS. By doing so, we aim enhance understanding provide novel insights for treatment.

Язык: Английский

Процитировано

0