Metabolites, Год журнала: 2024, Номер 14(11), С. 593 - 593
Опубликована: Ноя. 4, 2024
: The incidence of many diseases increases with age and leads to multimorbidity, characterized by the presence multiple in old age. This phenomenon is closely related systemic metabolic changes; most suitable way study it through metabolomics. use accumulated metabolomic data characterize this at system level may provide additional insight into nature strength aging-disease relationships.
Язык: Английский
Nutrients, Год журнала: 2024, Номер 16(22), С. 3830 - 3830
Опубликована: Ноя. 8, 2024
Aging is the result of a complex interplay physical, environmental, and social factors, leading to an increased prevalence chronic age-related diseases that burden health care systems. As global population ages, it crucial understand aged immune system, which undergoes declines in both innate adaptive immunity. This decline exacerbates aging process, creating feedback loop accelerates onset diseases, including infectious autoimmune disorders, cancer. Intervention strategies, dietary adjustments, pharmacological treatments, immunomodulatory therapies, represent promising approaches counteract immunosenescence. These interventions aim enhance function by improving activity interactions aging-affected cells, or modulating inflammatory responses through suppression excessive cytokine secretion pathway activation. Such strategies have potential restore homeostasis mitigate inflammation, thus reducing risk linked aging. In summary, this review provides insights into effects underlying mechanisms immunosenescence, as well its interventions, with particular emphasis on relationship between aging, immunity, nutritional factors.
Язык: Английский
Процитировано
4
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Фев. 20, 2025
Diabetes mellitus (DM) is a global health crisis affecting millions, with islet transplantation emerging as promising treatment strategy to restore insulin production. This review synthesizes the current research on single-cell and spatial transcriptomics in context of transplantation, highlighting their potential revolutionize DM management. Single-cell RNA sequencing, offers detailed look into diversity functionality within grafts, identifying specific cell types states that influence graft acceptance function. Spatial complements this by mapping gene expression tissue's context, crucial for understanding microenvironment surrounding transplanted islets interactions host tissues. The integration these technologies comprehensive view cellular microenvironments, elucidating mechanisms underlying function, survival, rejection. instrumental developing targeted therapies enhance performance patient outcomes. emphasizes significance avenues informing clinical practices improving outcomes patients through more effective strategies. Future directions include application personalized medicine, developmental biology, regenerative predict disease progression responses. Addressing ethical technical challenges will be successful implementation integrated approaches practice, ultimately enhancing our ability manage improve quality life.
Язык: Английский
Процитировано
0
Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102738 - 102738
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
iMeta, Год журнала: 2025, Номер unknown
Опубликована: Апрель 12, 2025
Abstract Aging‐related decline and adaptation are complex, multifaceted processes that affect various tissues increase risk of chronic diseases. To characterize key changes in cross‐tissue aging, we performed comprehensive proteomic metabolomic analyses across 21 solid plasma samples, alongside shotgun metagenomic profiling fecal microbial communities young aged mice. Our findings revealed widespread aging‐rewired inflammation, characterized by complement system activation universal immunoglobulins accumulation multiple tissues. This inflammatory remodeling significantly enhanced vulnerability to aging‐related tissue injury. Moreover, identified organ‐specific organ‐enriched proteins with high functional specificity. Among these, were closely linked disorders arising from lipid metabolism dysfunction. Analysis multi‐tissue profiles aging disrupted inter‐tissue metabolic coupling, activities polyunsaturated fatty acids metabolism, gut microbiota homeostasis. Aged mice exhibited a marked decrease Escherichia an Helicobacter , strongly correlating alterations omega‐3 omega‐6 acid abundances. Through multi‐omics integration, molecular hubs driving organismal responses aging. Collectively, our study uncovers extensive aging‐associated tissues, emphasizing the interplay between systemic inflammation dysbiosis‐driven remodeling. These provide deeper insights into development healthy perspective.
Язык: Английский
Процитировано
0
Metabolites, Год журнала: 2024, Номер 14(11), С. 593 - 593
Опубликована: Ноя. 4, 2024
: The incidence of many diseases increases with age and leads to multimorbidity, characterized by the presence multiple in old age. This phenomenon is closely related systemic metabolic changes; most suitable way study it through metabolomics. use accumulated metabolomic data characterize this at system level may provide additional insight into nature strength aging-disease relationships.
Язык: Английский
Процитировано
0