Single-cell genomics and spatial transcriptomics in islet transplantation for diabetes treatment: advancing towards personalized therapies
Lisha Mou,
No information about this author
Tony Bowei Wang,
No information about this author
Yuxian Chen
No information about this author
et al.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 20, 2025
Diabetes
mellitus
(DM)
is
a
global
health
crisis
affecting
millions,
with
islet
transplantation
emerging
as
promising
treatment
strategy
to
restore
insulin
production.
This
review
synthesizes
the
current
research
on
single-cell
and
spatial
transcriptomics
in
context
of
transplantation,
highlighting
their
potential
revolutionize
DM
management.
Single-cell
RNA
sequencing,
offers
detailed
look
into
diversity
functionality
within
grafts,
identifying
specific
cell
types
states
that
influence
graft
acceptance
function.
Spatial
complements
this
by
mapping
gene
expression
tissue's
context,
crucial
for
understanding
microenvironment
surrounding
transplanted
islets
interactions
host
tissues.
The
integration
these
technologies
comprehensive
view
cellular
microenvironments,
elucidating
mechanisms
underlying
function,
survival,
rejection.
instrumental
developing
targeted
therapies
enhance
performance
patient
outcomes.
emphasizes
significance
avenues
informing
clinical
practices
improving
outcomes
patients
through
more
effective
strategies.
Future
directions
include
application
personalized
medicine,
developmental
biology,
regenerative
predict
disease
progression
responses.
Addressing
ethical
technical
challenges
will
be
successful
implementation
integrated
approaches
practice,
ultimately
enhancing
our
ability
manage
improve
quality
life.
Language: Английский
Immune Alterations with Aging: Mechanisms and Intervention Strategies
Weiru Yu,
No information about this author
Yifei Yu,
No information about this author
Siyuan Sun
No information about this author
et al.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(22), P. 3830 - 3830
Published: Nov. 8, 2024
Aging
is
the
result
of
a
complex
interplay
physical,
environmental,
and
social
factors,
leading
to
an
increased
prevalence
chronic
age-related
diseases
that
burden
health
care
systems.
As
global
population
ages,
it
crucial
understand
aged
immune
system,
which
undergoes
declines
in
both
innate
adaptive
immunity.
This
decline
exacerbates
aging
process,
creating
feedback
loop
accelerates
onset
diseases,
including
infectious
autoimmune
disorders,
cancer.
Intervention
strategies,
dietary
adjustments,
pharmacological
treatments,
immunomodulatory
therapies,
represent
promising
approaches
counteract
immunosenescence.
These
interventions
aim
enhance
function
by
improving
activity
interactions
aging-affected
cells,
or
modulating
inflammatory
responses
through
suppression
excessive
cytokine
secretion
pathway
activation.
Such
strategies
have
potential
restore
homeostasis
mitigate
inflammation,
thus
reducing
risk
linked
aging.
In
summary,
this
review
provides
insights
into
effects
underlying
mechanisms
immunosenescence,
as
well
its
interventions,
with
particular
emphasis
on
relationship
between
aging,
immunity,
nutritional
factors.
Language: Английский
Cognitive Frailty: A Comprehensive Clinical Paradigm Beyond Cognitive Decline
Ageing Research Reviews,
Journal Year:
2025,
Volume and Issue:
unknown, P. 102738 - 102738
Published: March 1, 2025
Language: Английский
Integrative cross‐tissue analysis unveils complement‐immunoglobulin augmentation and dysbiosis‐related fatty acid metabolic remodeling during mammalian aging
Feng Zhang,
No information about this author
Rong Li,
No information about this author
Yasong Liu
No information about this author
et al.
iMeta,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 12, 2025
Abstract
Aging‐related
decline
and
adaptation
are
complex,
multifaceted
processes
that
affect
various
tissues
increase
risk
of
chronic
diseases.
To
characterize
key
changes
in
cross‐tissue
aging,
we
performed
comprehensive
proteomic
metabolomic
analyses
across
21
solid
plasma
samples,
alongside
shotgun
metagenomic
profiling
fecal
microbial
communities
young
aged
mice.
Our
findings
revealed
widespread
aging‐rewired
inflammation,
characterized
by
complement
system
activation
universal
immunoglobulins
accumulation
multiple
tissues.
This
inflammatory
remodeling
significantly
enhanced
vulnerability
to
aging‐related
tissue
injury.
Moreover,
identified
organ‐specific
organ‐enriched
proteins
with
high
functional
specificity.
Among
these,
were
closely
linked
disorders
arising
from
lipid
metabolism
dysfunction.
Analysis
multi‐tissue
profiles
aging
disrupted
inter‐tissue
metabolic
coupling,
activities
polyunsaturated
fatty
acids
metabolism,
gut
microbiota
homeostasis.
Aged
mice
exhibited
a
marked
decrease
Escherichia
an
Helicobacter
,
strongly
correlating
alterations
omega‐3
omega‐6
acid
abundances.
Through
multi‐omics
integration,
molecular
hubs
driving
organismal
responses
aging.
Collectively,
our
study
uncovers
extensive
aging‐associated
tissues,
emphasizing
the
interplay
between
systemic
inflammation
dysbiosis‐driven
remodeling.
These
provide
deeper
insights
into
development
healthy
perspective.
Language: Английский
Advances in spatial transcriptomics and its application in the musculoskeletal system
Bone Research,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: May 16, 2025
While
bulk
RNA
sequencing
and
single-cell
have
shed
light
on
cellular
heterogeneity
potential
molecular
mechanisms
in
the
musculoskeletal
system
both
physiological
various
pathological
states,
spatial
localization
of
cells
molecules
intercellular
interactions
within
tissue
context
require
further
elucidation.
Spatial
transcriptomics
has
revolutionized
biological
research
by
simultaneously
capturing
gene
expression
profiles
situ
information
tissues,
gradually
finding
applications
research.
This
review
provides
a
summary
recent
advances
its
application
to
system.
The
classification
characteristics
data
acquisition
techniques
are
briefly
outlined,
with
an
emphasis
widely-adopted
representative
technologies
latest
technological
breakthroughs,
accompanied
concise
workflow
for
incorporating
into
role
revealing
system,
particularly
during
developmental
processes,
is
thoroughly
summarized.
Furthermore,
discoveries
achievements
this
emerging
omics
tool
addressing
inflammatory,
traumatic,
degenerative,
tumorous
diseases
compiled.
Finally,
challenges
future
directions
transcriptomics,
as
field
discussed.
Language: Английский
Spatial Insights in Cardiovascular Aging
Aging and Disease,
Journal Year:
2025,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2025
Language: Английский
Aging and Pathological Conditions Similarity Revealed by Meta-Analysis of Metabolomics Studies Suggests the Existence of the Health and Age-Related Metapathway
Metabolites,
Journal Year:
2024,
Volume and Issue:
14(11), P. 593 - 593
Published: Nov. 4, 2024
:
The
incidence
of
many
diseases
increases
with
age
and
leads
to
multimorbidity,
characterized
by
the
presence
multiple
in
old
age.
This
phenomenon
is
closely
related
systemic
metabolic
changes;
most
suitable
way
study
it
through
metabolomics.
use
accumulated
metabolomic
data
characterize
this
at
system
level
may
provide
additional
insight
into
nature
strength
aging-disease
relationships.
Language: Английский