Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 2743 - 2765
Опубликована: Фев. 1, 2025
The
crosstalk
between
H-type
endothelial
cells
(ECs)
and
macrophages
is
critical
for
maintaining
angiogenesis
osteogenesis
in
bone
homeostasis.
As
core
components
of
type
H
vessels,
ECs
respond
to
various
pro-angiogenic
signals,
forming
specialized
vascular
structures
characterized
by
high
expression
platelet-endothelial
cell
adhesion
molecule-1
(CD31)
mucin
(EMCN),
thereby
facilitating
angiogenesis-osteogenesis
coupling
during
formation.
Macrophages,
as
key
immune
the
perivascular
region,
are
primarily
classified
into
classically
activated
pro-inflammatory
M1
phenotype
selectively
anti-inflammatory
M2
phenotype,
performing
dual
functions
regulating
local
tissue
homeostasis
innate
immunity.
In
recent
years,
complex
vessel
has
garnered
significant
interest
context
bone-related
diseases.
Orderly
regulation
immunity
provides
a
new
direction
preventing
metabolic
disorders
such
osteoporosis
osteoarthritis.
However,
their
interactions
remain
insufficiently
understood,
with
limited
clinical
data
available.
This
review
comprehensively
examines
intricate
diverse
phenotypes,
Insights
signaling
pathways
that
regulate
crosstalk,
focusing
on
roles
osteogenesis.
Furthermore,
discusses
interventions
targeting
this
challenges
remain.
These
insights
may
offer
perspectives
provide
theoretical
foundation
developing
novel
therapeutic
strategies.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(21), С. 15772 - 15772
Опубликована: Окт. 30, 2023
Osteoporosis
is
a
widespread
systemic
disease
characterized
by
decrease
in
bone
mass
and
an
imbalance
of
the
microarchitecture
tissue.
Experimental
clinical
studies
devoted
to
investigating
main
pathogenetic
mechanisms
osteoporosis
revealed
important
role
estrogen
deficiency,
inflammation,
oxidative
stress,
cellular
senescence,
epigenetic
factors
development
resorption
due
osteoclastogenesis,
decreased
mineralization
tissue
formation
reduced
function
osteoblasts
caused
apoptosis
age-depended
differentiation
osteoblast
precursors
into
adipocytes.
The
current
review
was
conducted
describe
basic
at
molecular
levels
elucidate
most
promising
therapeutic
strategies
therapy
based
on
articles
cited
PubMed
up
September
2023.
PubMed,
Год журнала:
2023,
Номер
4(4), С. 248 - 269
Опубликована: Янв. 1, 2023
While
bone
tissue
is
known
for
its
inherent
regenerative
abilities,
various
pathological
conditions
and
trauma
can
disrupt
meticulously
regulated
processes
of
formation
resorption.
Bone
engineering
aims
to
replicate
the
extracellular
matrix
as
well
sophisticated
biochemical
mechanisms
crucial
effective
regeneration.
Traditionally,
field
has
relied
on
external
agents
like
growth
factors
pharmaceuticals
modulate
these
processes.
Although
efficacious
in
certain
scenarios,
this
strategy
compromised
by
limitations
such
safety
issues
transient
nature
compound
release
half-life.
Conversely,
bioactive
elements
zinc
(Zn),
magnesium
(Mg)
silicon
(Si),
have
garnered
increasing
interest
their
therapeutic
benefits,
superior
stability,
reduced
biotic
risks.
Moreover,
are
often
incorporated
into
biomaterials
that
function
multifaceted
components,
facilitating
regeneration
via
on-demand.
By
elucidating
mechanistic
roles
efficacy
elements,
review
establish
a
robust
clinically
viable
advanced
Biomolecules,
Год журнала:
2024,
Номер
14(3), С. 357 - 357
Опубликована: Март 16, 2024
Inflammation
is
a
major
driver
of
heterotopic
ossification
(HO),
condition
abnormal
bone
growth
in
site
that
not
normally
mineralized.
This
review
will
examine
recent
findings
on
the
roles
inflammation
and
immune
system
fibrodysplasia
ossificans
progressiva
(FOP).
FOP
genetic
aggressive
progressive
HO
formation.
We
also
how
may
be
valuable
target
for
treatment
HO.
Rationale/Recent
findings:
Multiple
lines
evidence
indicate
key
role
driving
pathogenesis.
Critical
cell
types
include
macrophages,
mast
cells,
adaptive
working
through
hypoxia
signaling
pathways,
stem
differentiation
vascular
regulatory
inflammatory
cytokines.
In
addition,
clinical
reports
suggest
potential
modulators
management
FOP.
The
central
mediators
suggests
common
blocking
both
non-genetic
forms
Future
research
focusing
identification
novel
targets
help
support
testing
therapies
other
related
conditions.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Год журнала:
2024,
Номер
157, С. 106661 - 106661
Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Abstract
The
intricate
nature
of
oral-maxillofacial
structure
and
function,
coupled
with
the
dynamic
oral
bacterial
environment,
presents
formidable
obstacles
in
addressing
repair
regeneration
bone
defects.
Numerous
characteristics
should
be
noticed
repair,
such
as
irregular
morphology
defects,
homeostasis
between
hosts
microorganisms
cavity
complex
periodontal
structures
that
facilitate
epithelial
ingrowth.
Therefore,
necessitates
restoration
materials
adhere
to
stringent
specific
demands.
This
review
starts
exploring
these
particular
requirements
by
introducing
bones
then
summarizes
classifications
current
respect
composition
structure.
Additionally,
we
discuss
modifications
including
improving
mechanical
properties,
optimizing
surface
topography
pore
adding
bioactive
components
elements,
compounds,
cells
their
derivatives.
Ultimately,
organize
a
range
potential
optimization
strategies
future
perspectives
for
enhancing
materials,
physical
environment
manipulation,
microbial
modulation,
osteo-immune
regulation,
smart
stimuli-responsive
multifaceted
approach
poly-pathic
treatment,
hope
providing
some
insights
researchers
this
field.
In
summary,
analyzes
demands
especially
alveolar
bone,
concludes
corresponding
biomaterials
aims
inspire
research
pursuit
more
effective
treatment
outcomes.
Three-dimensional
(3D)
printing,
also
known
as
additive
manufacturing,
has
revolutionized
the
production
of
physical
3D
objects
by
transforming
computer-aided
design
models
into
layered
structures,
eliminating
need
for
traditional
molding
or
machining
techniques.
In
recent
years,
hydrogels
have
emerged
an
ideal
printing
feedstock
material
fabrication
hydrated
constructs
that
replicate
extracellular
matrix
found
in
endogenous
tissues.
Hydrogels
seen
significant
advancements
since
their
first
use
contact
lenses
biomedical
field.
These
led
to
development
complex
3D-printed
structures
include
a
wide
variety
organic
and
inorganic
materials,
cells,
bioactive
substances.
The
most
commonly
used
techniques
fabricate
hydrogel
scaffolds
are
extrusion,
jetting,
vat
photopolymerization,
but
novel
methods
can
enhance
resolution
structural
complexity
printed
emerged.
applications
be
broadly
classified
four
categories—tissue
engineering
regenerative
medicine,
cell
culture
disease
modeling,
drug
screening
toxicity
testing,
devices
delivery
systems.
Despite
applications,
number
challenges
still
addressed
maximize
printing.
improving
complexity,
optimizing
viability
function,
cost
efficiency
accessibility,
addressing
ethical
regulatory
concerns
clinical
translation.
