Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Июнь 26, 2023
Abstract
In
plant
microbial
fuel
cells
or
p-MFCs
living
plants
photosynthesize
between
two
electrodes.
The
exudes
organic
waste
material
from
the
roots.
rhizosphere,
bacteria
consume
these
wastes
by
oxidizing
them
in
contrast
to
atmosphere
that
reduces
it.
This
redox
reaction
along
with
photosynthesis
can
be
harnessed
as
an
energy
source
form
of
bioelectricity.
this
work,
Withania
somnifera
(L.)
Dunal
was
used
for
generating
bioelectricity
root
exudates
and
matter
available
soil.
An
open
circuit
voltage
930
±
21
mV
achieved
multiple
cycles
operation.
cell
further
increased
1260
140
enrichment
discards
vegetable
matter.
peak
recorded
1400
mV.
Graphite
fibre
felt
electrodes
ensured
uniform
growth
power
densities
were
at
57
mW/m
2
84
without
respectively.
ATR-FTIR
demonstrated
complete
degradation
specific
compounds
attached
carbon
matrix
soil
polysaccharide
content
enrichments.
Additionally,
work
also
monitored
changes
pH
its
homogeneity,
impact
photosynthetically
active
radiation,
humidity,
presence
CO
air,
how
it
affects
ultimately
microbes
rhizosphere
which
accounted
bioremediation
resultant
production.
SEM
imaging
confirmed
importance
anaerobic
environment
electrode
properties
allow
conductive
biofilms
electrochemically
present
Molecules,
Год журнала:
2023,
Номер
28(3), С. 1208 - 1208
Опубликована: Янв. 26, 2023
Withania
somnifera
L.
Dunal
(Ashwagandha),
a
key
medicinal
plant
native
to
India,
is
used
globally
manage
various
ailments.
This
review
focuses
on
the
traditional
uses,
botany,
phytochemistry,
and
pharmacological
advances
of
its
plant-derived
constituents.
It
has
been
reported
that
at
least
62
crucial
48
inferior
primary
secondary
metabolites
are
present
in
W.
leaves,
29
among
these
found
roots
leaves
chiefly
steroidal
compounds,
lactones,
alkaloids,
amino
acids,
etc.
In
addition,
whole
shrub
parts
possess
activities
such
as
anti-leukotriene,
antineoplastic,
analgesic,
anti-oxidant,
immunostimulatory,
rejuvenating
properties,
mainly
observed
by
vitro
demonstration.
However,
course
medical
use
remains
unknown.
provides
comprehensive
understanding
somnifera,
which
will
be
useful
for
mechanism
studies
potential
applications
well
development
rational
quality
control
system
therapeutic
material
future.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Март 29, 2023
Withania
somnifera
(L.)
Dunal
belongs
to
the
nightshade
family
Solanaceae
and
is
commonly
known
as
Ashwagandha.
It
pharmacologically
a
significant
medicinal
plant
of
Indian
sub-continent,
used
in
Ayurvedic
indigenous
systems
medicine
for
more
than
3,000
years.
rich
reservoir
pharmaceutically
bioactive
constituents
withanolides
(a
group
300
naturally
occurring
C-28
steroidal
lactones
with
an
ergostane-based
skeleton).
Most
biological
activities
W.
have
been
attributed
two
key
withanolides,
namely,
withaferin-A
withanolide-D.
In
addition,
such
withanosides,
sitoindosides,
lactones,
alkaloids
are
also
present
broad
spectrum
therapeutic
potential.
Several
research
groups
worldwide
discovered
various
molecular
targets
,
inhibiting
activation
nuclear
factor
kappa-B
promoting
apoptosis
cancer
cells.
enhances
dopaminergic
D2
receptor
activity
(relief
Parkinson’s
disease).
The
active
principles
sitoindosides
VII-X
possess
free
radical
properties.
Withanolide-D
increases
radio
sensitivity
human
cells
via
deoxyribonucleic
acid
(DNA)
damage
non-homologous
end-joining
repair
(NHEJ)
pathways.
Withanolide-V
may
serve
potential
inhibitor
against
main
protease
(Mpro)
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
combat
COVID.
docking
studies
revealed
that
withanolide-A
inhibits
acetyl-cholinesterase
brain,
which
could
be
drug
treat
Alzheimer’s
disease.
Besides,
reduces
expression
N-methyl-D-aspartate
(NMDA)
receptor,
responsible
memory
loss
epileptic
rats.
This
review
demonstrates
source
other
constituents,
can
safe
chronic
diseases
due
minimal
side
effects
pre-clinical
studies.
These
results
interesting
signify
clinical
trials
should
conducted
prove
efficacy
settings.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Авг. 2, 2024
Ashwagandha
or
Withania
somnifera
is
an
herbal
plant
belonging
to
the
Solanaceae
family.
Because
of
its
wide
range
phytochemicals,
ashwagandha
root
extract
has
been
used
in
numerous
research
studies,
either
alone
conjunction
with
other
natural
plants,
for
various
biomedical
applications,
which
include
anti-microbial,
anti-inflammatory,
anti-stress,
anti-tumor,
cardioprotective,
and
neuroprotective
properties.
Additionally,
it
improves
endothelial
function,
lowers
reactive
oxygen
species,
controls
apoptosis,
mitochondrial
function.
These
properties
make
a
useful
treatment
variety
conditions,
including
age-related
symptoms,
anxiety,
neurodegenerative
diseases,
diabetes,
stress,
arthritis,
fatigue,
cognitive/memory
impairment.
Despite
benefits
supplementation,
there
have
just
four
meta-analyses
on
herb's
effectiveness
treating
neurobehavioral
disorders,
impotence,
infertility.
Moreover,
no
reviews
exist
that
examine
how
affects
antioxidant
response
physical
sports
performance.
Consequently,
goal
this
study
was
analyze
scientific
literature
regarding
effects
consumption
athletic
International Journal of Food Properties,
Год журнала:
2023,
Номер
26(1), С. 581 - 590
Опубликована: Фев. 3, 2023
Many
people
in
developing
countries
mainly
depend
on
medicinal
plants
like
Withania
somnifera
and
their
products
for
healthcare.
In
this
study,
reflux
maceration
extraction
methods
were
applied
to
investigate
total
phenolic
(TPC)
flavonoid
contents
(TFC);
antioxidant
properties
of
extracts
toward
DPPH
hydrogen
peroxide
(H2O2)
studied.
Highest
TPC
was
detected
with
methanol
value
198.24
±
1.16
mg
GAE/g
TFC
31.52
0.91
QE/g.
The
minimum
amount
observed
aqueous
extract
(101.41
1.07
GAE/g)
the
ethyl
acetate
9.72
1.32
maximum
radical
scavenging
estimated
81.98
0.49%
H2O2
obtained
acetone
76.18
1.06%.
major
identified
molecules
Heptasiloxane,1,1,3,3,5,5,7,7,9,9,11,11,13,13-tetradecamethyl-(50.04%),
trans-2,4
Dimethylthiane,
S,
S-
dioxide
(4.09%)
broad
spectrum
antibacterial
activity
Escherichia
coli
extract.
both
techniques
best
extracting
solvent
as
antioxidants
well
activities.
International Journal of Secondary Metabolite,
Год журнала:
2024,
Номер
11(1), С. 63 - 77
Опубликована: Янв. 25, 2024
Withania
somnifera
has
been
used
for
a
long
time
in
traditional
medicine.
Its
crude
extract,
dried
powder,
and
purified
metabolites
from
mature
plants
have
shown
promising
therapeutic
potential.
To
further
investigate
its
potential,
the
detection
of
phytochemicals
with
anticancer
antimicrobial
properties
vegetative
stage
is
essential.
Hence,
this
study
was
done
to
identify
phytochemical
constituents
using
GC-MS
analysis
activities
methanolic
extracts
stem,
leaf,
root
W.
somnifera.
The
air-dried
plant
parts
were
extracted
methanol
at
low
pressure
concentrate
rotary
evaporator
40°C.
phytochemicals,
Shimadzu
GCMSQP2010,
Japan,
NIST107.LIB
database.
identified
35
unique
peaks
In
leaves,
antibacterial
included
cyclotrisiloxane,
hexamethyl,
high
abundance,
cyclohexasiloxane,
dodecamethyl,
least
abundance.
roots,
2,2-dimethoxybutane,
cathinone,
found
properties,
whereas
trans-2,3-epoxyoctane,
properties.
phytoconstituents
octasiloxane,
1,1,3,3,5,5,7,7,9,9,11,11,13,13,15,15-hexadecamethyl,
benzenemethanol,
alpha.-(1-aminoethyl),
be
most
abundant
abundant,
respectively,
while
arabinitol
pentaacetate
had
both
activities.
At
stage,
studies
revealed
occurrence
potential
Critical Reviews in Analytical Chemistry,
Год журнала:
2024,
Номер
unknown, С. 1 - 25
Опубликована: Фев. 1, 2024
Withanolides
are
the
class
of
steroidal
molecules
getting
greater
emphasis
in
recent
years.
Quality
control
throughout
manufacturing
and
storage
period
is
often
one
key
problems
that
have
restricted
their
broad
use
India's
indigenous
Ayurvedic
medical
systems
for
thousands
Because
diverse
clinical
potential,
withanolides
received
a
great
deal
scientific
attention.
Analytical
techniques
being
devised
automated
isolation,
identification,
estimation
every
single
protein
within
cell
as
well
herbal
extracts
withanolides,
due
to
which
now
researchers
interested
determining
effects
metabolism
various
stimuli
on
expression,
made
study
easier.
This
discusses
potential
hyphenated
analytical
methods
reliable
understanding
molecular
signaling
features,
proteome
evaluation
characterization
addition
examining
existing
methodological
limitations.
The
choice
analysis,
however,
relies
nature
sample
matrix,
aim
sensitivity
technique.
Nutrients,
Год журнала:
2024,
Номер
16(15), С. 2481 - 2481
Опубликована: Июль 31, 2024
,
commonly
known
as
Ashwagandha,
has
been
popular
for
many
years.
Numerous
studies
have
shown
that
the
extract
of
this
plant,
due
to
its
wealth
active
substances,
can
induce
anti-inflammatory,
neuroprotective,
immunomodulatory,
hepatoprotective,
cardioprotective,
anti-diabetic,
adaptogenic,
anti-arthritic,
anti-stress,
and
antimicrobial
effects.
This
review
examines
impact
Ashwagandha
on
vascular
endothelium,
inflammation,
lipid
metabolism,
cardiovascular
outcomes.
Studies
extracts
exhibit
an
anti-angiogenic
effect
by
inhibiting
endothelial
growth
factor
(VEGF)-induced
capillary
sprouting
formation
lowering
mean
density
microvessels.
Furthermore,
results
numerous
highlight
anti-inflammatory
role
extract,
action
plant
causes
a
decrease
in
expression
pro-inflammatory
cytokines.
Interestingly,
withanolides,
present
root,
ability
inhibit
differentiation
preadipocytes
into
adipocytes.
Research
also
proved
Natural Product Communications,
Год журнала:
2025,
Номер
20(4)
Опубликована: Апрель 1, 2025
Traditional
medicine
has
played
a
key
role
in
cancer
treatment,
particularly
developing
countries
where
herbal
remedies
are
extensively
utilized.
Ethnopharmacological
knowledge
highlighted
several
medicinal
plants
traditionally
used
to
treat
cancers.
However,
only
fraction
of
these
have
undergone
scientific
evaluation
validate
their
anticancer
potential.
This
review
summarizes
the
ethnopharmacological
use,
preclinical
studies,
and
clinical
trial
data
plant-derived
compounds
with
properties.
Preclinical
investigations
demonstrated
substantial
cytotoxic
activities
plant
extracts
isolated
fractions
against
various
human
cell
lines.
For
instance,
from
Acokanthera
schimperi,
Clematis
simensis,
Euphorbia
schimperiana,
Kalanchoe
petitiana
,
Plumbago
zeylanicum
potent
across
types,
IC50
values
ranging
between
0.086
6.37
μg/mL.
Building
on
findings,
progressed
trials.
Curcumin
Curcuma
longa
is
undergoing
Phase
II
for
advanced
pancreatic
cancer.
Tea
polyphenols
*indole-3-carbinol/3,3-diindolylmethane
shown
efficacy
trials
multiple
myeloma
breast
cancer,
respectively.
Besides,
epigallocatechin,
lycopene,
resveratrol
(Polygonum,
sulforaphane
(
Brassica
oleracea
),
roscovitine/seliciclib,
thymoquinone,
piperine,
Berberine
genistein
under
I–III
integrates
knowledge,
data,
evidence,
showing
drug
discovery.
While
significant
progress
been
made,
further
studies
required
isolate,
characterize,
elucidate
mechanisms
action
bioactive
compounds.
Bridging
traditional
contemporary
research
offers
promising
avenues
development
novel
chemotherapeutic
chemopreventive
agents,
advancing
fight
