Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 10, 2023
Abstract
Cancer
is
one
of
the
major
causes
death
in
modern
world,
and
incidence
varies
considerably
based
on
race,
ethnicity,
region.
Novel
cancer
treatments,
such
as
surgery
immunotherapy,
are
ineffective
expensive.
In
this
situation,
ion
channels
responsible
for
cell
migration
have
appeared
to
be
most
promising
targets
treatment.
This
research
presents
findings
organic
compounds
present
Albizia
lebbeck
ethanolic
extracts
(ALEE),
well
their
impact
anti-migratory,
anti-proliferative
cytotoxic
potentials
MDA-MB
231
MCF-7
human
breast
lines.
addition,
artificial
intelligence
(AI)
models,
multilayer
perceptron
(MLP),
extreme
gradient
boosting
(XGB),
learning
machine
(ELM)
were
performed
predict
vitro
both
lines,
our
experimental
data.
The
composition
ALEE
was
studied
using
gas
chromatography-mass
spectrometry
(GC-MS)
analysis.
Cytotoxicity,
anti-proliferations,
anti-migratory
activity
extract
Tryphan
Blue,
MTT,
Wound
Heal
assay,
respectively.
Among
various
concentrations
(2.5
~
200
µg/mL)
ALLE
that
used
study,
2.5
10
µg/mL
revealed
potential
with
increased
concentrations,
they
did
not
show
any
effect
proliferation
cells
(P
<
0.05;
n
≥
3).
Furthermore,
three
data-driven
Multi-layer
Extreme
(ELM),
ability
treated
Overall,
plant
does
affect
type
demonstrated
effects
reducing
migration.
XGB
outperformed
MLP
ELM
models
performance
efficiency
by
up
3%
1%
MCF
2%
MDA-MB231,
respectively,
testing
phase.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 5, 2025
Traditional
medicine
uses
the
roots
and
rhizomes
of
Polygonum
bistorta
L.
(Polygonaceae)
to
treat
cough,
bronchitis,
other
respiratory
infections.
Our
goal
was
gain
insights
into
lung
protective
effects
P.
against
lipopolysaccharide-induced
acute
injury
in
rats,
along
with
possible
mechanism(s).
The
outcomes
revealed
deliberate
quantities
total
phenolic
flavonoid
contents
156.2
±
5.13
GAE/g
179.45
2.08
mg
QE/g,
respectively.
Crude
extract
possesses
a
maximum
inhibitory
potential
81.77%
0.62%
for
acetylcholinesterase
eserine.
Acute
oral
toxicity
study
LD
50
beyond
7
g/kg.
Plant
markedly
restored
LPS-induced
hypoxemia,
pulmonary
edema,
histopathological
alterations,
leukocyte
infiltration
lung.
ELISA
testing
on
BALF
found
that
plant
efficiently
reinstated
superoxide
dismutase,
anti-oxidant
capacity,
malondialdehyde,
oxidative
stress.
qRT-PCR
indicated
decline
endotoxin-induced
overproduction
pro-inflammatory
markers,
stress,
transcription
factor,
downregulated
antioxidant
extract-treated
groups.
Furthermore,
24
metabolites
were
identified
quantified
via
GC-MS.
A
molecular
docking
procedure
implemented
bioactive
evaluate
their
inhibiting
AChE.
In
conclusion,
mitigate
inflammation
stress
by
improving
redox
signaling
NF-ĸβ
(p65)
pathways
can
thus
play
role
strategies
overcoming
therapeutic
challenges.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(6), С. 858 - 858
Опубликована: Июнь 8, 2023
Breast
cancer
is
a
common
affecting
women
worldwide,
and
it
progresses
from
breast
tissue
to
other
parts
of
the
body
through
process
called
metastasis.
Albizia
lebbeck
valuable
plant
with
medicinal
properties
due
some
active
biological
macromolecules,
it's
cultivated
in
subtropical
tropical
regions
world.
This
study
reports
phytochemical
compositions,
cytotoxic,
anti-proliferative
anti-migratory
potential
A.
methanolic
(ALM)
extract
on
strongly
weakly
metastatic
MDA-MB
231
MCF-7
human
cells,
respectively.
Furthermore,
we
employed
compared
an
artificial
neural
network
(ANN),
adaptive
neuro-fuzzy
inference
system
(ANFIS),
multilinear
regression
analysis
(MLR)
predict
cell
migration
treated
cells
various
concentrations
using
our
experimental
data.
Lower
ALM
(10,
5
&
2.5
μg/mL)
showed
no
significant
effect.
Higher
(25,
50,
100
200
revealed
effect
cytotoxicity
proliferation
when
untreated
group
(p
<
0.05;
n
≥
3).
decrease
motility
index
increased
The
comparative
models
observed
that
both
classical
linear
MLR
AI-based
could
metastasis
cells.
Overall,
promising
an-metastatic
concentration
incubation
period.
outcomes
data
best
performance.
They
will
provide
future
development
assessing
efficacies
plants
Asian Journal of Agriculture and Biology,
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 1, 2023
Plants,
their
extracts,
and
plant
essential
oils
are
considered
prominent
sources
of
new
therapeutic
substances.Nowadays,
medicinal
plants
like
herbs
attain
the
keen
interest
consumers
researchers.The
present
study
evaluated
Piper
betle
(P.betle)
Persicaria
odorata
(P.odorata)
leaf
extracts
for
qualitative
quantitative
phytochemical
screening.The
analysis
P.
presented
occurrence
tannins,
flavonoids,
saponins,
phenols,
glycosides,
volatile
oils.The
higher
total
phenolic
content
tannins
were
quantified
from
methanolic
extract.Additionally,
it
showed
increased
antioxidant
activity
compared
to
extracts.The
in
vitro
antibacterial
potential
both
was
estimated
against
Salmonella
enterica,
Pseudomonas
aeruginosa,
Escherichia
coli,
Bacillus
subtilis,
Staphylococcus
aureus,
Candida
albicans,
Aspergillus
brasiliensis.The
extract
antifungal
these
selected
strains.
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Дек. 14, 2023
Cancer
is
one
of
the
major
causes
death
in
modern
world,
and
incidence
varies
considerably
based
on
race,
ethnicity,
region.
Novel
cancer
treatments,
such
as
surgery
immunotherapy,
are
ineffective
expensive.
In
this
situation,
ion
channels
responsible
for
cell
migration
have
appeared
to
be
most
promising
targets
treatment.
This
research
presents
findings
organic
compounds
present
Albizia
lebbeck
ethanolic
extracts
(ALEE),
well
their
impact
anti-migratory,
anti-proliferative
cytotoxic
potentials
MDA-MB
231
MCF-7
human
breast
lines.
addition,
artificial
intelligence
(AI)
models,
multilayer
perceptron
(MLP),
extreme
gradient
boosting
(XGB),
learning
machine
(ELM)
were
performed
predict
vitro
both
lines,
our
experimental
data.
The
composition
ALEE
was
studied
using
gas
chromatography-mass
spectrometry
(GC-MS)
analysis.
Cytotoxicity,
anti-proliferations,
anti-migratory
activity
extract
Tryphan
Blue,
MTT,
Wound
Heal
assay,
respectively.
Among
various
concentrations
(2.5-200
μg/mL)
that
used
study,
2.5-10
μg/mL
revealed
potential
with
increased
concentrations,
they
did
not
show
any
effect
proliferation
cells
(P
<
0.05;
n
≥
3).
Furthermore,
three
data-driven
Multi-layer
Extreme
(ELM),
ability
treated
Overall,
plant
do
affect
type
demonstrated
effects
reducing
migration.
XGB
outperformed
MLP
ELM
models
performance
efficiency
by
up
3%
1%
MCF
2%
MDA-MB231,
respectively,
testing
phase.
Journal of Agriculture and Food Research,
Год журнала:
2024,
Номер
16, С. 101190 - 101190
Опубликована: Май 3, 2024
In
Ethiopia,
medicinal
herbs
have
played
a
prominent
role
in
relieving
pain
and
curing
various
diseases
for
humans
animals
many
years.
However,
consumers
don't
know
what
kinds
of
phytochemicals
are
the
plants
or
amount
metal
they
contain.
Thus,
this
study,
polyphenol
content,
flavonoid
antioxidant
capacities,
antibacterial
activity
level
metals
Asparagus
africanus
root,
Ferula
communis,
Stephania
abyssinia,
Brucea
antidysenterica
Vernonia
amygdalina,
were
analyzed.
Identifying
phytochemicals,
activities,
levels
ensures
their
safety
efficacy
provides
deeper
understanding
healing
properties
areas
where
modern
medicines
not
easily
accessible.
The
was
determined
by
2,2-diphenyl-
1-picrylhydrazyl
(DPPH)
radical
assay,
evaluated
disc
diffusion
method.
Among
studied
plant
extracts,
amygdalina
displayed
maximum
phenolic
content
(810
mg
GAE/100
g),
(515.78
QE/100
DPPH
scavenging
(14.42
AAE/g),
whereas
least
total
(160.82
(30.65
(1.14
AAE/g)
recorded
africanus.
highest
inhibition
zone
recorded,
with
an
inhibitory
11
mm
S.
aurous
E.
coli.
obtained
gram-negative
bacteria
(K.
pneumonia)
diameter
less
than
8
mm.
contained
Mn
Fe,
while
Cu
Zn
found
to
be
abyssinia.
Cr
only
detected
Cd
below
detection
limit.
Due
better
properties,
extracts
these
might
used
as
natural
starting
material
treating
cancer
prepare
anti-cancer
drugs.
ACS Omega,
Год журнала:
2023,
Номер
8(44), С. 40982 - 41003
Опубликована: Окт. 27, 2023
Ashwagandha,
also
known
as
Withania
somnifera
(WS),
is
an
ayurvedic
botanical
plant
with
numerous
applications
in
dietary
supplements
and
traditional
medicines
worldwide.
Due
to
the
restorative
qualities
of
its
roots,
WS
has
potent
therapeutic
value
Indian
(Ayurvedic,
Unani,
Siddha)
modern
medicine
recognized
"Indian
ginseng".
The
presence
phytochemical
bioactive
compounds
such
withanolides,
withanosides,
alkaloids,
flavonoids,
phenolic
important
role
nutritional
properties
WS.
Thus,
choice
part
extraction
solvents,
conventional
techniques,
plays
a
establishing
potential
nutraceutical
product.
recently
made
way
into
food
products,
baked
goods,
juices,
beverages,
sweets,
dairy
items.
review
aims
cover
key
perspectives
about
terms
description,
phytochemistry,
structural
significance,
earlier
reported
methodologies
along
analytical
pharmacological
landscape
area.
It
attempts
iterate
limitations
further
insights
techniques
standardization
regulatory
framework.
presents
future
development
prospective
foods
or
functional
foods.
Cogent Food & Agriculture,
Год журнала:
2024,
Номер
10(1)
Опубликована: Фев. 15, 2024
The
rising
interest
in
bioactive
phyto-compounds,
known
for
their
antioxidant,
phenolic,
and
flavonoid
properties,
has
focused
attention
on
Moringa
oleifera.
With
its
abundant
phyto-molecules,
is
a
promising
source
biomolecule
extraction.
As
significant
vegetable
crop,
provides
ample
nutrients
that
can
be
efficiently
extracted
using
novel
methodologies.
This
study
aims
to
optimize
ultrasound-assisted
extraction
from
leaves,
considering
diverse
parameter
combinations
improved
yield
quality.
Ultrasound-assisted
extraction,
notable
advancement,
considers
parameters
like
amplitude,
temperature,
time.
Employing
Response
Surface
Methodology
(RSM)
with
20
simulated
runs,
this
investigation
assessed
yield,
Total
Phenol
Content
(TPC),
Flavonoid
(TFC),
Radical
Scavenging
Activity
(RSA).
optimized
technique
yielded
an
of
12.78-23.28%,
TPC
100.12-149.22
mg
GAE/g,
TFC
14.43-20.19
QE/g,
RSA
58.87-85.08%.
Increased
amplitude
power,
higher
shorter
time
contributed
enhanced
GC-MS
profiling
identified
various
compounds
the
leaf
extracts,
showcasing
potential
applications
nutraceutical
industries.
Journal of Education Health and Sport,
Год журнала:
2024,
Номер
66, С. 50081 - 50081
Опубликована: Апрель 19, 2024
Introduction
Ashwagandha,
a
traditional
Indian
plant,
is
gaining
increasive
attention
from
scientists
worldwide
due
to
its
potential
health
benefits,
especially
in
the
context
of
antibacterial
and
anticancer
properties.
Aim
study
The
aim
this
review
was
discuss
recent
findings
regarding
impact
Withania
Somnifera
on
effect
applications
therapy.
Materials
methods:
paper
created
based
Pubmed
Google
Scholar
database.
literature
reviewed
using
keywards:
,,Ashwagandha”,
,,Withania
Somnifera”,
,,antibacterial
”,
,,anticancer”,
,,side
effects”,
,,breats
cancer”.
Results
Studies
have
confirmed
Somnifera,
exhibits
significant
anticacterial
effects.
It
inhibits
growth
both
Gram-negative
Gram-positive
bacteria.
Futhermore,
it
demonstrates
activity,
breast
cancer,
by
stimulating
apoptosis,
induction
cytotoxic
effects
cancerous
cells
increasing
cell
sensitivity
radiation.
Conclusion
Despite
promising
results,
futher
research
benefits
particulary
long
term,
essential.
There
growing
need
more
potencial
Ashwagandha
treatment
various
disorders
including
cancer
bacterial
infections
develop
effective
therapeutic
strategies.
for
large
randomized
studies
comparing
term
clinical
effectiveness
emphasized
