Precision medicine for personalized cholecystitis care: integrating molecular diagnostics and biotherapeutics

Bulletin of the National Research Centre/Bulletin of the National Research Center, Год журнала: 2024, Номер 48(1)

Опубликована: Сен. 12, 2024

Abstract Background Acute cholecystitis, inflammation of the gallbladder, can lead to serious complications if not promptly diagnosed and managed. Conventional therapies have limitations, necessitating newer personalized approaches. Main body abstract This review examines recent advances transforming cholecystitis care. Diagnostically, molecular techniques like next-generation sequencing rapidly identify causative microbes from gallbladder specimens, enabling targeted antimicrobial therapy. Regarding treatment, phage therapy uses viruses lyse pathogenic bacteria. RNA interference CRISPR-Cas9 gene editing silence microbial virulence factors. Probiotics competitively exclude pathogens. Robotics fluorescence imaging refine surgical techniques. Additional emerging modalities include biosensors detecting inflammatory mediators, regenerative tissue engineering using stem cells, artificial intelligence for real-time decision support. However, optimal integration novel technologies with current best practices remains unknown. Further research is needed validate optimize diagnostics therapeutics cholecystitis. Short conclusions Advances in sequencing, CRISPR editing, robotics, other biotechnologies promise transform precision management when thoughtfully implemented. controlled trials are still required define conventional supportive care antibiotics.

Язык: Английский

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Artemisinin and its derivatives throughout the therapeutic mechanisms and clinical potential

Discover Chemistry., Год журнала: 2025, Номер 2(1)

Опубликована: Фев. 10, 2025

Язык: Английский

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Predictive roles of Asprosin and Gremlin-1 expression in Egyptian pediatric patients with type 1 diabetes

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 20, 2025

Diabetes mellitus type 1 (insulin-dependent) (T1DM) is characterized by the selective destruction of insulin-producing pancreatic beta. Asprosin and Gremlin-1 may have roles in T1DM, however these are not fully established. The expression genes their protein levels, was considerably higher T1DM patients' blood compared to control group (P < 0.001). area under curve 50 age- sex-matched persons that serum patients. quantities were measured ELISA, real-time PCR used evaluate peripheral blood. Serum concentration, expression, 0.87, 0.997, 0.912, 0.949, respectively. best marker for diagnosis with 96% sensitivity, 92% specificity, 94% accuracy. can significantly increase risk 276 folds, followed 84.33 folds. diagnostic which had diabetes be raised times when asprosin present, present.

Язык: Английский

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Advancing frontiers in skin offensive odor management: from innovative diagnostics to cutting-edge treatments and emerging technologies

Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)

Опубликована: Март 8, 2025

Язык: Английский

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Exploring the relationship between exanthematous diseases and early-onset type 1 diabetes in children

Jornal de Pediatria, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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