Exploring the relationship between exanthematous diseases and early-onset type 1 diabetes in children DOI Creative Commons
Massimo Pettoello‐Mantovani, Pietro Ferrara, Ida Giardino

et al.

Jornal de Pediatria, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Precision medicine for personalized cholecystitis care: integrating molecular diagnostics and biotherapeutics DOI Creative Commons

Tamer A. Addissouky

Bulletin of the National Research Centre/Bulletin of the National Research Center, Journal Year: 2024, Volume and Issue: 48(1)

Published: Sept. 12, 2024

Abstract Background Acute cholecystitis, inflammation of the gallbladder, can lead to serious complications if not promptly diagnosed and managed. Conventional therapies have limitations, necessitating newer personalized approaches. Main body abstract This review examines recent advances transforming cholecystitis care. Diagnostically, molecular techniques like next-generation sequencing rapidly identify causative microbes from gallbladder specimens, enabling targeted antimicrobial therapy. Regarding treatment, phage therapy uses viruses lyse pathogenic bacteria. RNA interference CRISPR-Cas9 gene editing silence microbial virulence factors. Probiotics competitively exclude pathogens. Robotics fluorescence imaging refine surgical techniques. Additional emerging modalities include biosensors detecting inflammatory mediators, regenerative tissue engineering using stem cells, artificial intelligence for real-time decision support. However, optimal integration novel technologies with current best practices remains unknown. Further research is needed validate optimize diagnostics therapeutics cholecystitis. Short conclusions Advances in sequencing, CRISPR editing, robotics, other biotechnologies promise transform precision management when thoughtfully implemented. controlled trials are still required define conventional supportive care antibiotics.

Language: Английский

Citations

4
Artemisinin and its derivatives throughout the therapeutic mechanisms and clinical potential DOI Creative Commons
Majeed M. A. Ali

Discover Chemistry., Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 10, 2025

Language: Английский

Citations

0
Predictive roles of Asprosin and Gremlin-1 expression in Egyptian pediatric patients with type 1 diabetes DOI Creative Commons
Al‐Shimaa M. Abas, Marwa M. Esawy, Fatma Kamel

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 20, 2025

Diabetes mellitus type 1 (insulin-dependent) (T1DM) is characterized by the selective destruction of insulin-producing pancreatic beta. Asprosin and Gremlin-1 may have roles in T1DM, however these are not fully established. The expression genes their protein levels, was considerably higher T1DM patients' blood compared to control group (P < 0.001). area under curve 50 age- sex-matched persons that serum patients. quantities were measured ELISA, real-time PCR used evaluate peripheral blood. Serum concentration, expression, 0.87, 0.997, 0.912, 0.949, respectively. best marker for diagnosis with 96% sensitivity, 92% specificity, 94% accuracy. can significantly increase risk 276 folds, followed 84.33 folds. diagnostic which had diabetes be raised times when asprosin present, present.

Language: Английский

Citations

0
Advancing frontiers in skin offensive odor management: from innovative diagnostics to cutting-edge treatments and emerging technologies DOI
Majeed M. A. Ali

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: March 8, 2025

Language: Английский

Citations

0
Exploring the relationship between exanthematous diseases and early-onset type 1 diabetes in children DOI Creative Commons
Massimo Pettoello‐Mantovani, Pietro Ferrara, Ida Giardino

et al.

Jornal de Pediatria, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0