Stress in lockdown: exploring the interplay and effects of cortisol and psychological distress in parent-child dyads
Journal of Neural Transmission,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Язык: Английский
Intergenerational impact of childhood trauma on hair cortisol concentrations in mothers and their young infants
Comprehensive Psychoneuroendocrinology,
Год журнала:
2023,
Номер
14, С. 100167 - 100167
Опубликована: Янв. 20, 2023
Alterations
in
stress
regulation
and
function
of
the
hypothalamic-pituitary-adrenal
(HPA)
axis
during
infancy
may
be
a
risk
factor
for
development
psychopathology
later
life.
Maternal
childhood
trauma,
depression,
stressful
life
events
are
individually
associated
with
HPA
dysregulation.
Less
is
known
about
their
interdependent
influence
on
maternal
infant
at
populations.
In
sample
mothers
history
depressive-,
and/or
anxiety
disorders
infants
we
explored
if
current
depressive
symptomatology,
recent
were
long-term
cortisol
levels
three
months
postpartum.
Data
available
89
49
infants.
All
fulfilled
criteria
lifetime
or
disorder.
Diagnosis
was
established
diagnostic
interview.
Current
symptomatology
assessed
Edinburgh
Postnatal
Depression
Scale
(EPDS),
State-Trait
Anxiety
Inventory
(STAI),
trauma
Childhood
Trauma
Questionnaire
(CTQ)
Everyday
Problem
Checklist
(EPC).
hair
concentrations
(HCC)
quantified
liquid
chromatography
tandem
mass
spectrometry
(LC-MS/MS)
after
birth.
Total
scores
CTQ
subscales,
EPDS,
STAI,
EPC
regressed
HCC
using
regression
analyses.
Differences
regarding
tested
t-tests.
Potential
confounders
identified
adjusted
for.
analyses,
positive
curvilinear
relationship
found
between
total
score
(n
=
83,
B
0.076,
SE
0.033,
p
.021),
but
not
depression
88,
−0.001,
0.011,
.931),
0.002,
0.004,
.650)
89,
0.018,
0.032,
.568).
Analyses
confounders.
A
negative
linear
49,
β
−0.264,
−0.006,
0.003,
.052),
45,
−0.182,
−0.011,
0.008,
.164),
−0.209,
−0.005,
.113)
46,
−0.128,
−0.022,
0.023,
.325).
relevant
characteristics.
Specifically,
emotional
physical
neglect
related
to
both
Results
suggest
that
more
prominent
altering
than
perinatal
stressors
disorders,
As
increased
psychiatric
disease,
future
studies
should
investigate
interplay
possible
factors
transgenerational
transmission,
intra-uterine
programming
axis,
including
(epi-)genetic
phenomena,
parenting
impairment.
Язык: Английский
Hair cortisol concentrations in pregnant women with bipolar, depressive, or schizophrenic spectrum disorders
Archives of Women s Mental Health,
Год журнала:
2024,
Номер
27(4), С. 577 - 584
Опубликована: Фев. 3, 2024
Abstract
Purpose
Maternal
cortisol
levels
in
pregnancy
may
support
the
growth
of
or
adversely
affect
fetal
organs,
including
brain.
While
moderate
are
essential
for
development,
excessive
prolonged
elevations
have
negative
health
consequences
both
mother
and
offspring.
Little
is
known
about
predictors
altered
hypothalamic–pituitary–adrenal
(HPA)
axis
activity
during
pregnancy.
This
study
examined
maternal
hair
concentration
(HCC)
3rd
trimester
relation
to
severe
psychopathology.
Methods
Hair
samples
were
collected
from
69
women,
32
with
a
lifetime
diagnosis
mental
disorders
(bipolar
I
II
disorder,
depressive
schizophrenic
spectrum
disorder),
37
non-clinical
controls.
trimester,
liquid
chromatography
tandem
mass
spectrometry
was
used
assessment.
Psychiatric
current
level
symptomatic
functioning
assessed
using
structured
clinical
interview
DSM-5
global
assessment
scale.
Results
Women
illness
had
significantly
elevated
HCC
compared
Poorer
also
associated
Conclusions
The
implications
alterations
on
infant
need
further
study.
Язык: Английский
The association between maternal symptoms of depression and hair glucocorticoids in infants across the perinatal period
Psychoneuroendocrinology,
Год журнала:
2022,
Номер
147, С. 105952 - 105952
Опубликована: Окт. 17, 2022
Язык: Английский
Longitudinal effects of maternal depressive and anxious symptomatology on child hair cortisol and cortisone from pregnancy to 5-years: The EDEN mother-child cohort
Psychoneuroendocrinology,
Год журнала:
2024,
Номер
162, С. 106957 - 106957
Опубликована: Янв. 11, 2024
Exposure
to
maternal
depressive
and
anxious
symptomatology
in
utero
after
birth
can
affect
child
outcomes.
One
proposed
mechanism
is
through
changes
stress
hormone
levels,
however
current
studies
present
inconsistent
findings,
further
research
needed
better
understand
the
impact
of
mental
health
on
response.
This
study
aims
add
limited
literature
by
analysing
longitudinal
data
ranging
from
24
weeks
amenorrhea
5
years
postpartum
among
281
mother-child
pairs
French
EDEN
cohort.
Hair
cortisol
cortisone
were
collected
children
at
four
time
points:
birth,
1,
3,
years.
Mothers
reported
via
Center
for
Epidemiologic
Studies
Depression
Scale
(CES-D)
(at
24-weeks
amenorrhea,
3-,
5-year
follow-up),
Edinburgh
Postnatal
(EPDS)
4,
8
12
months
postpartum).
Prenatal
anxiety
was
measured
State
Anxiety
Inventory
(STAI)
amenorrhea.
Group-based
trajectory
modelling
indicated
a
1-cluster
classification
hair
cortisol,
cortisol-to-cortisone
ratio,
as
analyses
did
not
reveal
subgroups
representing
different
profiles.
After
inverse
probability
weighting,
small
effects
showed
prenatal
significantly
associated
higher
levels
one
year.
linked
1
Postpartum
related
3-year-olds.
These
moderated
sex
or
socio-economic
status.
Further
why
there
are
associations
some
points
others
determine
any
potential
buffering
factors.
Язык: Английский
The Determination of Endogenous Steroids in Hair and Fur: A Systematic Review of Methodologies
The Journal of Steroid Biochemistry and Molecular Biology,
Год журнала:
2024,
Номер
246, С. 106649 - 106649
Опубликована: Ноя. 28, 2024
Язык: Английский
Associations of gestational anxiety and depression with neonatal hair steroid levels
Psychoneuroendocrinology,
Год журнала:
2024,
Номер
172, С. 107260 - 107260
Опубликована: Дек. 19, 2024
Язык: Английский
Associations between Maternal and Offspring Hair Cortisol Concentrations and Child Behavioral Symptoms in Mother-Child Pairs with Perinatal Mental Disorders
Children,
Год журнала:
2022,
Номер
9(6), С. 810 - 810
Опубликована: Май 31, 2022
Maternal
perinatal
mental
disorders
(PMD)
are
associated
with
developmental
and
behavioral
problems
in
children,
probably
mediated
by
the
programming
of
hypothalamic-pituitary-adrenal
(HPA)
axis.
Increased
cortisol
concentrations
during
antenatal
periods
have
been
related
to
long-term
effects
on
children's
behavior
stress
response.
We
aimed
investigate
association
hair
(HCC)
between
mothers,
(n
=
16)
without
PMD
30),
their
aged
18
48
months.
Participants
were
evaluated
a
clinical
interview
questionnaires
for
Depression
Anxiety
Stress
Scale
Child
Behavior
Checklist
ages
1½-5.
child
HCCs
compared
two
groups.
Children
group
had
increased
symptoms
attention
deficit
hyperactivity
disorder.
A
positive
linear
maternal
HCC
was
observed
only
total
sample
mother-child
dyads
control
group.
In
group,
significantly
anxiety/depression
symptoms.
Aggressive
oppositional/defiant
correlated
own
HCCs,
mother's
too.
These
findings
suggest
that
chronic
dysregulation
HPA
axis
associations
may
underlie
linkage
among
prolonged
stress,
behavioral/emotional
responses.
Язык: Английский
Parental Stress and Scalp Hair Cortisol in Excessively Crying Infants: A Case Control Study
Children,
Год журнала:
2021,
Номер
8(8), С. 662 - 662
Опубликована: Июль 30, 2021
Background:
Caring
for
an
excessively
crying
infant
(ECI)
can
be
stressful
mothers
and
fathers
is
associated
with
mental
bonding
problems.
Hair
cortisol
offers
a
unique
measure
the
biological
reaction
of
body
to
stress
over
time.
Methods:
In
this
case-control
study,
scalp
hair
concentrations
(HCC)
were
measured
using
liquid
chromatography-tandem
mass
spectrometry
(LC-MS)
in
35
23
their
ECIs.
The
control
group
consisted
64
63
non-ECIs
similar
age.
Parental
stress,
depression,
anxiety
assessed
validated
questionnaires.
Results:
Mean
HCC
significantly
lower
ECIs
(2.3
pg/mg,
95%
CI
1.8–2.9
1.6
1.3–2.0)
than
that
(3.2
3.0–3.7
2.9
2.5–3.5).
total
parents
within
ECIs,
not
negative
feelings.
group,
showed
positive
association
depression
(r
=
0.207,
p
0.020
r
0.221,
0.013).
infants,
no
differences
found
mean
between
ECI
group.
No
associations
maternal
HCC,
paternal
HCC.
Conclusion:
Parents
parents,
reflecting
diminished
response
hypothalamic-pituitary-adrenal
(HPA)
axis.
More
research
needed
examine
whether
decrease
pre-existing
or
caused
by
excessive
crying.
Язык: Английский
Intra- and inter-specific cortisol coregulation
Опубликована: Янв. 1, 2023
Coregulation
is
the
bidirectional
modulation
of
social
partners’
physiology,
including
hypothalamic-pituitary-adrenal
(HPA)
axis
activity,
and
it
key
for
forming
maintaining
attachment
bonds
between
individuals.
By
investigating
coregulation
acute
chronic
cortisol
in
dog-human,
dog-dog,
human-human
dyads,
this
thesis
aims
to
further
our
understanding
temporal
drivers
their
potential
links
attachment.
Chapter
1
outlines
how
regulates
reviews
existing
literature
parent-infant
spousal
non-human
human-non-human
dyads.
In
2,
I
describe
methodology
used
across
Chapters
3-6.
3
explores
whether
factors
commonly
associated
with
stronger
dyads
also
predict
dog-owner
strength.
4
tests
cohabiting
dogs,
demonstrates
that
absence
owner
(i.e.
an
external
influence)
may
strengthen
dog-dog
coregulation.
5
concentrations
(derived
from
hair)
enhance
study
coregulation,
presents
preliminary
evidence
suggesting
predictors
strength
depend
on
nature
measure
utilised
or
concentrations).
6
highlights
greater
dyad
similarity
Big-5
personality
traits
romantic
couples’
–
area
has
received
minimal
attention
literature.
Lastly,
general
discussion
(Chapter
7),
place
findings
a
wider
context
outline
implications
future
studies.
Overall,
results
3-6
knowledge
indicate
physiological
mechanism
shared
characteristics
types
relationships
species.
Additionally,
show
influences
inter-individual
differences
have
be
strength,
which
could
considerable
methodologies
studies
(provided
these
persist
larger
sample).
Язык: Английский