Journal of sport and health science/Journal of Sport and Health Science,
Год журнала:
2025,
Номер
unknown, С. 101064 - 101064
Опубликована: Май 1, 2025
The
potential
of
exercise
as
a
concurrent
therapy
for
actively
treated
primary
tumors
has
been
suggested
by
emerging
preclinical
and
observational
studies.
However,
clinical
trials
regarding
this
question
are
scarce.
Therefore,
we
conducted
randomized
controlled
trial
investigating
the
effects
aerobic
or
resistance
concomitant
to
neoadjuvant
chemotherapy
(NACT)
on
tumor
size.
IN
THE
BENEFIT
STUDY
(GERMAN
TITLE:
BEwegung
bei
NEoadjuvanter
Chemotherapie
zur
Verbesserung
der
FITness),
patients
with
breast
cancer
scheduled
NACT
were
randomly
assigned
supervised
training
(RT,
n
=
60)
(AT,
twice
weekly
during
waitlist
control
group
(WCG,
60).
outcome,
"change
in
size",
well
secondary
outcomes
pathologic
complete
response
(pCR),
type
surgery
(breast
conserving/mastectomy),
axillary
lymph
node
dissection
(ALND,
yes/no),
premature
discontinuation
(yes/no),
relative
dose
intensity
(RDI)
derived
from
records.
Due
highly
skewed
distribution,
outcome
was
categorized.
Multiple
(ordinal)
logistic
regression
analyses
performed.
Overall,
there
no
significant
difference
post-intervention
size
between
RT
AT
WCG.
effect
modification
hormone
receptor
(HR)
status
(pinteraction
0.030).
Among
HR+
tumors,
results
suggest
beneficial
shrinkage
(odds
ratio
(OR)
2.37,
95%CI:
0.97‒5.78),
pCR
(OR
3.21,
0.97‒10.61);
ALND
3.76,
0.78‒18.06)
compared
slightly
less
pronounced.
For
HR-
subtypes,
RDI
found
3.71,
1.20‒11.50)
similarly
2.58,
0.88‒7.59).
Both
had
favorable
(no
vs.
yes)
2.34,
1.10‒5.06),
irrespective
status.
While
overall
group,
seem
beneficially
affect
pCR,
reduce
need
among
cancers,
prevent
low
cancers.
These
warrant
confirmation
further
trials.
World Journal of Surgical Oncology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 2, 2025
The
prognostic
significance
of
the
C-reactive
protein-albumin-lymphocyte
(CALLY)
index
in
digestive
system
neoplasms
(DSNs)
has
been
investigated
several
studies,
but
inconsistencies
remain
between
results
different
studies.
Therefore,
aim
this
study
was
to
confirm
CALLY
patients
with
DSNs
and
its
association
clinicopathological
characteristics
(CPCs).
databases
PubMed,
Cochrane
Library,
Web
Science,
Research
Square
Embase
were
systematically
searched
for
clinical
trials
up
1
November
2024.
value
predicting
overall
survival
(OS),
disease-free
(DFS)
recurrence-free
(RFS)
versus
cancer-specific
(CSS)
confirmed
by
calculating
combined
hazard
ratio
(HR)
95%
CI.
OR
CI
calculated
assess
CPCs
DSNs.
A
total
18
studies
7916
included
study.
Pooled
analysis
showed
that
lower
associated
poor
OS,
DFS,
RFS
CSS
significantly
associated.
In
addition,
low
male
gender,
T3-T4,
lymph
node
metastasis,
vessel
invasion,
complications,
stage
III-IV
surgical
approach
However,
there
no
histological
type,
adjuvant
chemotherapy,
neoadjuvant
chemotherapy.
meta-analysis,
a
PROSPERO
CRD42024622973.
Critical Reviews in Oncology/Hematology,
Год журнала:
2025,
Номер
unknown, С. 104718 - 104718
Опубликована: Апрель 1, 2025
This
review
aims
to
summarize
the
recommendations
endorsed
by
scientific
societies
regarding
physical
activity
for
patients
with
cancer.
A
systematic
search
was
conducted
identify
guidelines
and
published
in
last
15
years
dedicated
cancer
patients.
The
AGREE
II
instrument
used
assess
methodological
quality
of
guidelines.
Results
are
presented
as
qualitative
synthesis.
total
11
met
inclusion
criteria.
Seven
were
considered
high
quality,
scoring
≥60%
tool.
All
recommended
include
aerobic
resistance
training
types
activities.
Regarding
dosage,
most
suggested
a
generic
150minutes/week
moderate-intensity
plus
twice
week.
Three
reported
instructions
exercise
prescription,
including
frequency,
intensity,
duration
sessions.
Six
testing/medical
clearance
instructions,
9
provided
considerations
adaptation/precautions,
7
detailed
specialists
referral.
Four
motivational
aspects
related
Although
important
steps
have
been
made
more
recent
recommendations,
effort
is
needed
produce
high-quality
research
exercise-oncology
field,
ultimate
aim
developing
tailored
B&G Bewegungstherapie und Gesundheitssport,
Год журнала:
2025,
Номер
41(02), С. 67 - 74
Опубликована: Апрель 1, 2025
Zusammenfassung
Körperliche
Aktivität
und
Training
haben
erhebliche
gesundheitliche
Vorteile,
die
über
physische
Gesundheit
hinausgehen.
Bewegung
wirkt
bio-psycho-sozial
kann
sowohl
präventiv
als
auch
therapeutisch
in
einem
breiten
Indikationsfeld
eingesetzt
werden.
Insbesondere
im
Bereich
der
kardiovaskulären
verbessert
körperliches
Effizienz
des
Herz-Kreislauf-Systems,
senkt
den
Blutdruck
beeinflusst
kardiometabolische
Parameter
wie
HbA1c-Wert
positiv.
Darüber
hinaus
hat
nachweislich
positive
Effekte
auf
Psyche
Depressionssymptome
wirksam
reduzieren.Diese
umfassenden
Wirkungen
treten
simultan
auf,
wobei
verschiedene
Bewegungsformen
unterschiedliche
haben.
Dennoch
lässt
sich
körperliche
eine
Art
Breitbandmedikament
betrachten.
Neben
absoluten
Wirksamkeit
von
Bewegungsinterventionen
wird
Folgenden
ihr
Vergleich
mit
medikamentösen
Therapien
sowie
mögliche
Wechselwirkungen
diskutiert.
stellt
somit
ein
hochwirksames
therapeutisches
Mittel
oder
unterstützendes
Element
bei
zahlreichen
epidemiologisch
bedeutsamen
Erkrankungen
dar.
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 25, 2025
Culinary
Medicine
(CM)
is
an
avenue
for
interdisciplinary
nutrition
education
intervention
utilizing
the
expertise
of
dietitians,
physicians,
and
other
health
care
professionals
(HCP).
Despite
positive
impacts
that
CM
interventions
can
have
on
health,
physician
knowledge
lacking
due
in
part
to
inadequate
medical
school
curriculum.
as
a
modality
promotes
disease
management
patients
providers,
so
it
critical
increase
competency
CM.
This
pilot
study
evaluated
impact
cancer
prevention
specific
curriculum
students'
(i)
risk
reduction
(CRR)
knowledge,
(ii)
CRR
assessment/counseling
attitudes
self-efficacy
clinical
care,
(iii)
personal
behaviors
cooking
skills.
Thirty-one
2nd
year
students
(CALM
students)
participated
seven,
3-hour
focused
sessions
were
compared
55
non-enrolled
(control
group).
Education
incorporated
lecture,
learning
activity,
experience
topics
including
dietary
patterns,
gut
inflammation,
metabolic
hormone
balance,
environmental
exposures,
practice/at
home.
A
46-item
online
pre-test
(09/23)
post-test
(03/24)
survey
assessed
standardized
measures
general
nutrition/cancer
attitudes/beliefs,
perceived
control
around
diet/
lifestyle
modifications;
intentions
integrating
strategies
practice.
78
(91%)
completed
both
surveys
findings
indicate
CALM
showed
significant
improvement
over
their
peers
scores
(β
=
0.265,
t
2.14,
p
<
0.05),
toward
setting
0.203,
2.00,
0.05)
confidence
patient
0.401,
4.05,
0.001).
Most
changes
occurred
being
able
make
plan
follow
through
with
(p
among
first
incorporate
evaluate
CRR-specific
competencies
education.
Given
lifetime
developing
high
Americans
(~40%),
implementation
providers
must
be
emphasized.
If
research
continues
demonstrate
success
future
cohorts,
innovative
approach
teaching
HCP
applicable
numerous
states.
Journal of sport and health science/Journal of Sport and Health Science,
Год журнала:
2025,
Номер
unknown, С. 101064 - 101064
Опубликована: Май 1, 2025
The
potential
of
exercise
as
a
concurrent
therapy
for
actively
treated
primary
tumors
has
been
suggested
by
emerging
preclinical
and
observational
studies.
However,
clinical
trials
regarding
this
question
are
scarce.
Therefore,
we
conducted
randomized
controlled
trial
investigating
the
effects
aerobic
or
resistance
concomitant
to
neoadjuvant
chemotherapy
(NACT)
on
tumor
size.
IN
THE
BENEFIT
STUDY
(GERMAN
TITLE:
BEwegung
bei
NEoadjuvanter
Chemotherapie
zur
Verbesserung
der
FITness),
patients
with
breast
cancer
scheduled
NACT
were
randomly
assigned
supervised
training
(RT,
n
=
60)
(AT,
twice
weekly
during
waitlist
control
group
(WCG,
60).
outcome,
"change
in
size",
well
secondary
outcomes
pathologic
complete
response
(pCR),
type
surgery
(breast
conserving/mastectomy),
axillary
lymph
node
dissection
(ALND,
yes/no),
premature
discontinuation
(yes/no),
relative
dose
intensity
(RDI)
derived
from
records.
Due
highly
skewed
distribution,
outcome
was
categorized.
Multiple
(ordinal)
logistic
regression
analyses
performed.
Overall,
there
no
significant
difference
post-intervention
size
between
RT
AT
WCG.
effect
modification
hormone
receptor
(HR)
status
(pinteraction
0.030).
Among
HR+
tumors,
results
suggest
beneficial
shrinkage
(odds
ratio
(OR)
2.37,
95%CI:
0.97‒5.78),
pCR
(OR
3.21,
0.97‒10.61);
ALND
3.76,
0.78‒18.06)
compared
slightly
less
pronounced.
For
HR-
subtypes,
RDI
found
3.71,
1.20‒11.50)
similarly
2.58,
0.88‒7.59).
Both
had
favorable
(no
vs.
yes)
2.34,
1.10‒5.06),
irrespective
status.
While
overall
group,
seem
beneficially
affect
pCR,
reduce
need
among
cancers,
prevent
low
cancers.
These
warrant
confirmation
further
trials.
