Curcumin: A Review of Its Effects on Human Health

Foods, Год журнала: 2017, Номер 6(10), С. 92 - 92

Опубликована: Окт. 22, 2017

Turmeric, a spice that has long been recognized for its medicinal properties, received interest from both the medical/scientific world and culinary enthusiasts, as it is major source of polyphenol curcumin. It aids in management oxidative inflammatory conditions, metabolic syndrome, arthritis, anxiety, hyperlipidemia. may also help exercise-induced inflammation muscle soreness, thus enhancing recovery performance active people. In addition, relatively low dose complex can provide health benefits people do not have diagnosed conditions. Most these be attributed to antioxidant anti-inflammatory effects. Ingesting curcumin by itself does lead associated due poor bioavailability, which appears primarily absorption, rapid metabolism, elimination. There are several components increase bioavailability. For example, piperine component black pepper and, when combined with curcumin, shown bioavailability 2000%. Curcumin agents provides multiple benefits. The purpose this review brief overview plethora research regarding

Язык: Английский

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The Essential Medicinal Chemistry of Curcumin

Journal of Medicinal Chemistry, Год журнала: 2017, Номер 60(5), С. 1620 - 1637

Опубликована: Янв. 11, 2017

Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in therapeutic use turmeric and relative ease isolation curcuminoids has led their extensive investigation. recently been classified both PAINS (pan-assay interference compounds) an IMPS (invalid metabolic panaceas) candidate. The likely false activity curcumin vitro vivo resulted >120 clinical trials against several diseases. No double-blinded, placebo controlled trial successful. This manuscript reviews essential medicinal chemistry provides evidence that unstable, reactive, nonbioavailable compound and, therefore, highly improbable lead. On basis this in-depth evaluation, potential new directions for research on are discussed.

Язык: Английский

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Challenges in liver cancer and possible treatment approaches

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2019, Номер 1873(1), С. 188314 - 188314

Опубликована: Ноя. 2, 2019

Язык: Английский

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Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice

Cancer Research and Treatment, Год журнала: 2014, Номер 46(1), С. 2 - 18

Опубликована: Янв. 15, 2014

Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000 citations. In addition, one hundred clinical studies have carried out curcumin. One of major problems curcumin perceived to be bioavailability. How should delivered vivo, how bioavailable it, well absorbed it metabolized, focus this review. Various formulations are currently available also discussed. Key words: Curcumin, Nano-formulation, Biological availability, Metabolism, Anticancer

Язык: Английский

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Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

British Journal of Pharmacology, Год журнала: 2016, Номер 174(11), С. 1325 - 1348

Опубликована: Сен. 17, 2016

Curcumin, a yellow pigment in the Indian spice Turmeric (Curcuma longa), which is chemically known as diferuloylmethane, was first isolated exactly two centuries ago 1815 by German Scientists, Vogel and Pelletier. However, according to pubmed database, study on its biological activity an antibacterial agent published 1949 Nature clinical trial reported The Lancet 1937. Although current database indicates almost 9000 publications curcumin, until 1990 there were less than 100 papers this nutraceutical. At molecular level, multitargeted has been shown exhibit anti-inflammatory through suppression of numerous cell signalling pathways including NF-κB, STAT3, Nrf2, ROS COX-2. Numerous studies have indicated that curcumin highly potent antimicrobial be active against various chronic diseases types cancers, diabetes, obesity, cardiovascular, pulmonary, neurological autoimmune diseases. Furthermore, compound also synergistic with other nutraceuticals such resveratrol, piperine, catechins, quercetin genistein. To date, over different trials completed clearly show safety, tolerability effectiveness humans. more populations are necessary prove potential This review's primary focus lessons learnt about from trials.

Язык: Английский

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Curcumin nanoformulations: A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment

Biomaterials, Год журнала: 2014, Номер 35(10), С. 3365 - 3383

Опубликована: Янв. 16, 2014

Язык: Английский

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Curcumin, a component of golden spice: From bedside to bench and back

Biotechnology Advances, Год журнала: 2014, Номер 32(6), С. 1053 - 1064

Опубликована: Апрель 30, 2014

Язык: Английский

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Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects

Molecules, Год журнала: 2019, Номер 24(16), С. 2930 - 2930

Опубликована: Авг. 13, 2019

Turmeric is a curry spice that originated from India, which has attracted great interest in recent decades because it contains bioactive curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin). Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione), lipophilic polyphenol may work as an anticancer, antibiotic, anti-inflammatory, anti-aging agent suggested by several vitro, vivo studies clinical trials. However, poor aqueous solubility, bioavailability, pharmacokinetic profiles limit curcumin’s therapeutic usage. To address these issues, curcumin formulations have been developed. suboptimal sample preparation analysis methodologies often hamper the accurate evaluation of bioactivities their efficacy. This review summarizes research on biological, pharmaceutical, analytical aspects curcumin. Various formulation techniques corresponding trials outcomes are discussed. A detailed comparison different (ultrasonic, pressurized liquid extraction, microwave, reflux) (FT-IR, FT-NIR, FT-Raman, UV, NMR, HPTLC, HPLC, LC-MS/MS) used for extraction quantification matrices, presented. Application optimal preparation, chromatographic separation, detection will significantly improve assessment biological activities curcuminoids.

Язык: Английский

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Carotenoids: biochemistry, pharmacology and treatment

British Journal of Pharmacology, Год журнала: 2016, Номер 174(11), С. 1290 - 1324

Опубликована: Сен. 17, 2016

Carotenoids and retinoids have several similar biological activities such as antioxidant properties, the inhibition of malignant tumour growth induction apoptosis. Supplementation with carotenoids can affect cell modulate gene expression immune responses. Epidemiological studies shown a correlation between high carotenoid intake in diet reduced risk breast, cervical, ovarian, colorectal cancers, cardiovascular eye diseases. Cancer chemoprevention by dietary involves mechanisms, including effects on gap junctional intercellular communication, factor signalling, cycle progression, differentiation-related proteins, retinoid-like receptors, response element, nuclear AP-1 transcriptional complex, Wnt/β-catenin pathway inflammatory cytokines. Moreover, stimulate proliferation B- T-lymphocytes, activity macrophages cytotoxic T-cells, effector T-cell function production Recently, beneficial carotenoid-rich vegetables fruits health decreasing certain diseases has been attributed to major carotenoids, β-carotene, lycopene, lutein, zeaxanthin, crocin (/crocetin) curcumin, due their effects. It is thought that act time- dose-dependent manner. In this review, we briefly describe immunological main used for treatment various possible mechanisms action.This article part themed section Principles Pharmacological Research Nutraceuticals. To view other articles visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc.

Язык: Английский

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Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications

Frontiers in Pharmacology, Год журнала: 2020, Номер 11

Опубликована: Сен. 15, 2020

Curcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries culinary and food coloring purposes, besides to be an ingredient various medicinal preparations widely in Ayurveda or Chinese medicine. In last decades, their biological activities have extensively studied. Thus, focus of this review is offer in-depth revision curcumin applications biotechnological industries, on health promotion disease prevention, with emphasis its antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, cardioprotective effects. Bioavailability, bioefficacy, safety, side effects quality parameters are also focused. Finally, curcumin' multidimensional applications, attractiveness optimization, agroindustrial procedures offset instability low-bioavailability, concerns upcoming strategies clinical application were covered.

Язык: Английский

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