The Chemistry of Curcumin: From Extraction to Therapeutic Agent

Molecules, Год журнала: 2014, Номер 19(12), С. 20091 - 20112

Опубликована: Дек. 1, 2014

Curcumin, a pigment from turmeric, is one of the very few promising natural products that has been extensively investigated by researchers both biological and chemical point view. While there are several reviews on pharmacological effects curcumin, chemistry comparatively scarcer. In this article, an overview different aspects unique research curcumin will be discussed. These include methods for extraction laboratory synthesis methods, photochemical degradation behind its metabolism. Additionally other reactions have relevance like nucleophilic addition reactions, metal chelation Recent advances in preparation new nanoconjugates with oxide nanoparticles also mentioned. Directions future investigations to undertaken suggested.

Язык: Английский

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Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

British Journal of Pharmacology, Год журнала: 2016, Номер 174(11), С. 1325 - 1348

Опубликована: Сен. 17, 2016

Curcumin, a yellow pigment in the Indian spice Turmeric (Curcuma longa), which is chemically known as diferuloylmethane, was first isolated exactly two centuries ago 1815 by German Scientists, Vogel and Pelletier. However, according to pubmed database, study on its biological activity an antibacterial agent published 1949 Nature clinical trial reported The Lancet 1937. Although current database indicates almost 9000 publications curcumin, until 1990 there were less than 100 papers this nutraceutical. At molecular level, multitargeted has been shown exhibit anti-inflammatory through suppression of numerous cell signalling pathways including NF-κB, STAT3, Nrf2, ROS COX-2. Numerous studies have indicated that curcumin highly potent antimicrobial be active against various chronic diseases types cancers, diabetes, obesity, cardiovascular, pulmonary, neurological autoimmune diseases. Furthermore, compound also synergistic with other nutraceuticals such resveratrol, piperine, catechins, quercetin genistein. To date, over different trials completed clearly show safety, tolerability effectiveness humans. more populations are necessary prove potential This review's primary focus lessons learnt about from trials.

Язык: Английский

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Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects

Molecules, Год журнала: 2019, Номер 24(16), С. 2930 - 2930

Опубликована: Авг. 13, 2019

Turmeric is a curry spice that originated from India, which has attracted great interest in recent decades because it contains bioactive curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin). Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione), lipophilic polyphenol may work as an anticancer, antibiotic, anti-inflammatory, anti-aging agent suggested by several vitro, vivo studies clinical trials. However, poor aqueous solubility, bioavailability, pharmacokinetic profiles limit curcumin’s therapeutic usage. To address these issues, curcumin formulations have been developed. suboptimal sample preparation analysis methodologies often hamper the accurate evaluation of bioactivities their efficacy. This review summarizes research on biological, pharmaceutical, analytical aspects curcumin. Various formulation techniques corresponding trials outcomes are discussed. A detailed comparison different (ultrasonic, pressurized liquid extraction, microwave, reflux) (FT-IR, FT-NIR, FT-Raman, UV, NMR, HPTLC, HPLC, LC-MS/MS) used for extraction quantification matrices, presented. Application optimal preparation, chromatographic separation, detection will significantly improve assessment biological activities curcuminoids.

Язык: Английский

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Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications

Frontiers in Pharmacology, Год журнала: 2020, Номер 11

Опубликована: Сен. 15, 2020

Curcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries culinary and food coloring purposes, besides to be an ingredient various medicinal preparations widely in Ayurveda or Chinese medicine. In last decades, their biological activities have extensively studied. Thus, focus of this review is offer in-depth revision curcumin applications biotechnological industries, on health promotion disease prevention, with emphasis its antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, cardioprotective effects. Bioavailability, bioefficacy, safety, side effects quality parameters are also focused. Finally, curcumin' multidimensional applications, attractiveness optimization, agroindustrial procedures offset instability low-bioavailability, concerns upcoming strategies clinical application were covered.

Язык: Английский

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Bioactivity of dietary polyphenols: The role of metabolites

Critical Reviews in Food Science and Nutrition, Год журнала: 2019, Номер 60(4), С. 626 - 659

Опубликована: Янв. 7, 2019

A polyphenol-rich diet protects against chronic pathologies by modulating numerous physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation and signaling transduction pathways. However, polyphenols have a low oral bioavailability mainly due to an extensive biotransformation mediated phase I II reactions in enterocytes liver but also gut microbiota. Despite bioavailability, most proved significant biological effects which brought into attention the bioavailability/high bioactivity paradox. In recent years, polyphenol metabolites attracted great interest many of them showed similar or higher intrinsic comparison parent compounds. There is huge body literature reporting on functions generated metabolic microbiota-mediated biotransformation. this respect, review highlights pharmacokinetic fate major dietary (resveratrol, curcumin, quercetin, rutin, genistein, daidzein, ellagitannins, proanthocyanidins) order further address efficacy biometabolites compared molecules. The present work strongly supports contribution health benefits polyphenols, thus offering better perspective understanding role played human health.

Язык: Английский

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Curcumin and Health

Molecules, Год журнала: 2016, Номер 21(3), С. 264 - 264

Опубликована: Фев. 25, 2016

Nowadays, there are some molecules that have shown over the years a high capacity to act against relevant pathologies such as cardiovascular disease, neurodegenerative disorders or cancer. This article provides brief review about origin, bioavailability and new research on curcumin synthetized derivatives. It examines beneficial effects health, delving into aspects cancer, effects, metabolic syndrome, antioxidant capacity, anti-inflammatory properties, neurological, liver respiratory disorders. Thanks all these activities, is positioned an interesting nutraceutical. reason why it has been subjected several modifications in its structure administration form permitted increase effectiveness different diseases, decreasing mortality morbidity associated pathologies.

Язык: Английский

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Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies

Biomedicine & Pharmacotherapy, Год журнала: 2016, Номер 85, С. 102 - 112

Опубликована: Дек. 5, 2016

Язык: Английский

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Dietary Curcumin: Correlation between Bioavailability and Health Potential

Nutrients, Год журнала: 2019, Номер 11(9), С. 2147 - 2147

Опубликована: Сен. 8, 2019

The yellow pigment curcumin, extracted from turmeric, is a renowned polyphenol with broad spectrum of health properties such as antioxidant, anti-inflammatory, anti-cancer, antidiabetic, hepatoprotective, anti-allergic, anti-dermatophyte, and neuroprotective. However, these are followed by poor pharmacokinetic profile which compromises its therapeutic potential. association low absorption the small intestine extensive reductive conjugative metabolism in liver dramatically weakens oral bioavailability. Several strategies inhibition curcumin adjuvants well novel solid liquid delivery systems have been tried to counteract rapid elimination body. Some drug deliveries can successfully enhance solubility, extending residence plasma, improving cellular uptake.

Язык: Английский

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Hypoxia-targeted drug delivery

Chemical Society Reviews, Год журнала: 2018, Номер 48(3), С. 771 - 813

Опубликована: Дек. 21, 2018

Hypoxia is a state of low oxygen tension found in numerous solid tumours.

Язык: Английский

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Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging

Oncotarget, Год журнала: 2018, Номер 9(24), С. 17181 - 17198

Опубликована: Март 30, 2018

// Carolina Simioni 1 , Giorgio Zauli Alberto M. Martelli 2 Marco Vitale 3, 4 Gianni Sacchetti 5 Arianna Gonelli and Luca Neri Department of Morphology, Surgery Experimental Medicine, University Ferrara, Italy Biomedical Neuromotor Sciences, Bologna, 3 Medicine Surgery, Parma, CoreLab, Azienda Ospedaliero-Universitaria di Life Sciences Biotechnology, Pharmaceutical Biology Laboratory, Correspondence to: Neri, email: [email protected] Keywords: exercise training; nutraceuticals; flavonoids intake; aging; antioxidant supplementation Received: January 26, 2018      Accepted: March 08, Published: 30, 2018 ABSTRACT Physical is considered to be one the beneficial factors a proper lifestyle nowadays seen as an indispensable element for good health, able lower risk disorders cardiovascular, endocrine osteomuscular apparatus, immune system diseases onset potential neoplasms. A moderate programmed physical has often been reported therapeutic both in adulthood aging, since capable promote fitness. Regular alleviates negative effects caused by free radicals offers many health benefits, including reduced all-cause mortality, sarcopenia skeletal muscle, chronic disease, premature death elderly people. However, performance also known induce oxidative stress, inflammation, muscle fatigue. Many efforts have carried out identify micronutrients natural compounds, nutraceuticals, prevent or attenuate exercise-induced stress inflammation. The aim this review discuss benefits deriving from constant activity intake compounds protect body stress. attention will focused mainly on three antioxidants, which are quercetin, resveratrol curcumin. Their properties described, well their expected increase through years can get favorable activity.

Язык: Английский

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