Pharmaceutical Development and Technology,
Год журнала:
2024,
Номер
29(5), С. 445 - 456
Опубликована: Апрель 20, 2024
The
digital
light
processing
(DLP)
printer
has
proven
to
be
effective
in
biomedical
and
pharmaceutical
applications,
as
its
printing
method
does
not
induce
shear
a
strong
temperature
on
the
resin.
In
addition,
DLP
good
resolution
print
quality,
which
makes
it
possible
complex
structures
with
customized
shape,
being
used
for
various
purposes
ranging
from
jewelry
application
areas.
big
disadvantage
of
is
lack
biocompatible
non-toxic
resin
market.
To
overcome
this
limitation,
an
ideal
use
needed.
must
have
appropriate
properties,
so
that
desired
format
printed
when
determined
wavelength
applied.
Thus,
aim
work
bring
basic
characteristics
resins
by
minimum
requirements
start
applications.
obtaining
devices
such
drug
delivery
systems.
Furthermore,
technology
allows
size,
shape
dosage,
providing
patient
personalized
treatment.
Materials Today Bio,
Год журнала:
2023,
Номер
23, С. 100823 - 100823
Опубликована: Окт. 1, 2023
Wound
care
and
treatment
can
be
critical
from
a
clinical
standpoint.
While
different
strategies
for
the
management
of
skin
wounds
have
been
developed,
limitations
inherent
in
current
approaches
necessitate
development
more
effective
alternative
strategies.
Advances
tissue
engineering
resulted
novel
promising
accelerating
wound
healing.
The
use
various
biomaterials
capable
regeneration
damaged
is
engineering.
In
this
regard,
cerium
oxide
nanoparticles
(CeO
Gels,
Год журнала:
2024,
Номер
10(2), С. 147 - 147
Опубликована: Фев. 14, 2024
Wound
healing
is
a
physiological
process
occurring
after
the
onset
of
skin
lesion
aiming
to
reconstruct
dermal
barrier
between
external
environment
and
body.
Depending
on
nature
duration
process,
wounds
are
classified
as
acute
(e.g.,
trauma,
surgical
wounds)
chronic
diabetic
ulcers)
wounds.
The
latter
take
several
months
heal
or
do
not
(non-healing
wounds),
usually
prone
microbial
infection
represent
an
important
source
morbidity
since
they
affect
millions
people
worldwide.
Typical
wound
treatments
comprise
debridement,
grafts/flaps)
non-surgical
topical
formulations,
dressings)
methods.
Modern
experimental
approaches
include
among
others
three
dimensional
(3D)-(bio)printed
dressings.
present
paper
reviews
recently
developed
3D
(bio)printed
hydrogels
for
applications,
especially
focusing
results
their
in
vitro
vivo
assessment.
advanced
hydrogel
constructs
were
printed
using
different
types
bioinks
natural
and/or
synthetic
polymers
mixtures
with
biological
materials)
printing
methods
extrusion,
digital
light
processing,
coaxial
microfluidic
bioprinting,
etc.)
incorporated
various
bioactive
agents
growth
factors,
antibiotics,
antibacterial
agents,
nanoparticles,
cells
fibroblasts,
keratinocytes,
mesenchymal
stem
cells,
endothelial
etc.).
Carbohydrate Polymers,
Год журнала:
2023,
Номер
321, С. 121298 - 121298
Опубликована: Авг. 14, 2023
Chronic
wounds,
especially
diabetic
ulcers,
pose
a
significant
challenge
in
regenerative
medicine.
Cellulose
derivatives
offer
remarkable
wound
management
properties,
such
as
effective
absorption
and
retention
of
exudates,
maintaining
an
optimal
moisture
environment
crucial
for
successful
chronic
regeneration.
However,
conventional
dressings
have
limited
efficacy
managing
healing
these
types
skin
lesions,
driving
scientists
to
explore
innovative
approaches.
The
emergence
3D
printing
has
enabled
personalized
that
meet
individual
patient
needs,
improving
the
process
comfort.
demanding
requirements
biocompatibility,
printability,
biofabrication
necessary
biologically
active
scaffolds.
potential
applications
nanocellulose
cellulose
derivative-based
inks
regeneration
remain
largely
unexplored.
Thus,
this
review
provides
comprehensive
overview
recent
advancements
cellulose-based
dressings.
composition
approaches
are
thoroughly
discussed,
including
functionalization
with
bioactive
molecules
antibiotics
improved
Similarly,
vitro
vivo
performance
is
extensively
examined.
In
summary,
aims
highlight
exceptional
advantages
diverse
printed
care.
Regenerative Therapy,
Год журнала:
2023,
Номер
24, С. 361 - 376
Опубликована: Сен. 4, 2023
Wounds
are
a
stern
healthcare
concern
in
the
growth
of
chronic
disease
conditions
as
they
can
increase
costs
and
complicate
internal
external
health.
Advancements
current
newer
management
systems
for
wound
healing
should
be
place
to
counter
health
burden
wounds.
Researchers
discovered
that
two-dimensional
(2D)
media
lacks
appropriate
real-life
detection
cellular
matter
these
have
highly
complicated
diverse
structures,
compositions,
interactions.
Hence,
innovation
towards
three-dimensional
(3D)
is
called
conquer
high-level
assessment
characterization
vivo
using
new
technologies.
The
application
modern
dressings
prepared
from
degenerated
natural
tissue,
biodegradable
biopolymer,
synthetic
polymer,
or
composite
materials
currently
an
area
tissue
regeneration
medicine.
Moreover,
integration
3D
printing
nanomaterial
science
promising
approach
with
potential
individualized,
flexible,
precise
technology
care
approaches.
This
review
encompasses
outcomes
various
investigations
on
recent
advances
3D-printed
drug-loaded
natural,
synthetic,
nanomaterials
healing.
challenges
associated
their
fabrication,
clinical
progress,
future
perspectives
also
addressed.
Abstract
Skin
wounds
have
become
an
important
issue
that
affects
human
health
and
burdens
global
medical
care.
Hydrogel
materials
similar
to
the
natural
extracellular
matrix
(ECM)
are
one
of
best
candidates
for
ideal
wound
dressings
most
feasible
choices
printing
inks.
Distinct
from
hydrogels
made
by
traditional
technologies,
which
lack
bionic
mechanical
properties,
3D
can
promptly
accurately
create
with
complex
bioactive
structures
potential
promote
tissue
regeneration
healing.
Herein,
a
comprehensive
review
multi‐functional
printing‐based
hydrogel
healing
is
presented.
The
first
summarizes
techniques
dressings,
including
photo‐curing,
extrusion,
inkjet,
laser‐assisted
printing.
Then,
properties
design
approaches
series
bioinks
composed
natural,
synthetic,
composite
polymers
described.
Thereafter,
application
in
variety
environments
discussed
depth,
hemostasis,
anti‐inflammation,
antibacterial,
skin
appendage
regeneration,
intelligent
monitoring,
machine
learning‐assisted
therapy.
Finally,
challenges
prospects
Abstract
Effective
wound
management
and
treatment
are
crucial
in
clinical
practice,
yet
existing
strategies
often
fall
short
fully
addressing
the
complexities
of
skin
healing.
Recent
advancements
tissue
engineering
have
introduced
innovative
approaches,
particularly
through
use
nanobiomaterials,
to
enhance
healing
process.
In
this
context,
titanium
dioxide
nanoparticles
(TiO2
NPs)
garnered
attention
due
their
excellent
biological
properties,
including
antioxidant,
anti-inflammatory,
antimicrobial
properties.
Furthermore,
these
can
be
modified
therapeutic
benefits.
Scaffolds
dressings
containing
TiO2
NPs
demonstrated
promising
outcomes
accelerating
enhancing
regeneration.
This
review
paper
covers
process,
properties
that
make
them
suitable
for
promoting
healing,
methods
synthesizing
NPs,
scaffolds
application
potential
toxicity
NPs.
Biofabrication,
Год журнала:
2023,
Номер
16(1), С. 015001 - 015001
Опубликована: Сен. 26, 2023
There
is
a
constant
demand
for
novel
materials/biomedical
devices
to
accelerate
the
healing
of
hard-to-heal
wounds.
Herein,
an
innovative
3D-printed
bioinspired
construct
was
developed
as
antibacterial/regenerative
scaffold
diabetic
wound
healing.
Hyaluronic/chitosan
(HA/CS)
ink
used
fabricate
bilayer
comprising
dense
plain
hydrogel
layer
topping
nanofibrous
obtained
by
incorporating
with
polylactic
acid
microspheres
(MS).
These
were
embedded
nano
ZnO
(ZNP)
or
didecyldimethylammonium
bromide
(DDAB)-treated
ZNP
(D-ZNP)
generate
antibacterial/healing
nano/micro
hybrid
biomaterials,
Z-MS@scaffold
and
DZ-MS@scaffold.
Plain
composite
scaffolds
blank
MS
(blank
MS@scaffold)
MS-free
ZNP@scaffold
D-ZNP@scaffold
comparison.
3D
printed
constructs
customizable
porosity
verified
SEM.
The
DZ-MS@scaffold
exhibited
largest
total
pore
area
well
highest
water-uptake
capacity
andin
vitroantibacterial
activity.
Treatment
ofStaphylococcus
aureus-infected
full
thickness
wounds
in
rats
indicated
superiority
evidenced
multiple
assessments.
afforded
95%
wound-closure,
infection
suppression,
effective
regulation
healing-associated
biomarkers
regeneration
skin
structure
14
d.
On
other
hand,
non-diabetic
acute
effectively
accelerated
simpler
less
porous
Z-MS@scaffold.
Information
provided
first-time
on
printing
using
non-electrospun
injectable
bioactive
particulate
constructs,
ZNP-functionalized
formulation
distinct
bioactivity
D-ZNP
powerful
antibacterial/wound
promotor.
In
addition,
findings
underscored
crucial
role
nanofibrous-MS
carrier
enhancing
physicochemical,
antibacterial,
regenerative
properties
DDAB-nano
ZnO.
conclusion,
merging
MS-boosted
functionalities
DDAB,
structural
characteristics
addition
those
scaffold,
provide
versatile
material
platform
biomedical
applications.
ACS Omega,
Год журнала:
2024,
Номер
9(40), С. 41107 - 41129
Опубликована: Сен. 16, 2024
This
review
examines
the
convergence
of
silver
nanoparticles
(AgNPs),
three-dimensional
(3D)
printing,
and
wound
healing,
focusing
on
significant
advancements
in
these
fields.
We
explore
unique
properties
AgNPs,
notably
their
strong
antibacterial
efficacy
potential
applications
enhancing
recovery.
Furthermore,
delves
into
3D
printing
technology,
discussing
its
core
principles,
various
materials
employed,
recent
innovations.
The
integration
AgNPs
3D-printed
structures
for
regenerative
medicine
is
analyzed,
emphasizing
benefits
this
combined
approach
identifying
challenges
that
must
be
addressed.
comprehensive
overview
aims
to
elucidate
current
state
field
direct
future
research
toward
developing
more
effective
solutions
healing.
