Pharmaceutical Research,
Journal Year:
2024,
Volume and Issue:
41(11), P. 2235 - 2246
Published: Oct. 21, 2024
Abstract
Purpose
The
application
of
3D
printing
technology
in
drug
delivery
is
often
limited
by
the
challenges
achieving
precise
control
over
release
profiles.
goal
this
study
was
to
apply
surface
equations
construct
printed
tablet
models,
adjust
functional
parameters
obtain
multiple
models
and
correlate
model
with
vitro
behavior.
Methods
This
reports
development
3D-printed
tablets
using
geometries
controlled
mathematical
functions
modulate
release.
Utilizing
fused
deposition
modeling
(FDM)
coupled
hot-melt
extrusion
(HME)
technology,
personalized
systems
were
produced
thermoplastic
polymers.
Different
shapes
(T1-T5)
varying
depth
parabolic
(
b
=
4,
2,
0,
-2,
-4
mm)
assess
impact
curvature
on
dissolution.
Results
T5
formulation,
greatest
curvature,
demonstrated
fastest
release,
complete
within
4
h.
In
contrast,
T1
T2
exhibited
a
slower
approximately
6
correlation
between
area
rate
confirmed,
supporting
predictions
Noyes-Whitney
equation.
Differential
Scanning
Calorimetry
(DSC)
Electron
Microscope
(SEM)
analyses
verified
uniform
dispersion
acetaminophen
consistency
internal
structures,
respectively.
Conclusions
geometry
effectively
tailored
profiles,
enhancing
patient
compliance
treatment
efficacy.
novel
approach
offers
significant
advancements
medicine
providing
highly
reproducible
adaptable
platform
for
optimizing
delivery.
Graphical
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
23, P. 100823 - 100823
Published: Oct. 1, 2023
Wound
care
and
treatment
can
be
critical
from
a
clinical
standpoint.
While
different
strategies
for
the
management
of
skin
wounds
have
been
developed,
limitations
inherent
in
current
approaches
necessitate
development
more
effective
alternative
strategies.
Advances
tissue
engineering
resulted
novel
promising
accelerating
wound
healing.
The
use
various
biomaterials
capable
regeneration
damaged
is
engineering.
In
this
regard,
cerium
oxide
nanoparticles
(CeO
Gels,
Journal Year:
2024,
Volume and Issue:
10(2), P. 147 - 147
Published: Feb. 14, 2024
Wound
healing
is
a
physiological
process
occurring
after
the
onset
of
skin
lesion
aiming
to
reconstruct
dermal
barrier
between
external
environment
and
body.
Depending
on
nature
duration
process,
wounds
are
classified
as
acute
(e.g.,
trauma,
surgical
wounds)
chronic
diabetic
ulcers)
wounds.
The
latter
take
several
months
heal
or
do
not
(non-healing
wounds),
usually
prone
microbial
infection
represent
an
important
source
morbidity
since
they
affect
millions
people
worldwide.
Typical
wound
treatments
comprise
debridement,
grafts/flaps)
non-surgical
topical
formulations,
dressings)
methods.
Modern
experimental
approaches
include
among
others
three
dimensional
(3D)-(bio)printed
dressings.
present
paper
reviews
recently
developed
3D
(bio)printed
hydrogels
for
applications,
especially
focusing
results
their
in
vitro
vivo
assessment.
advanced
hydrogel
constructs
were
printed
using
different
types
bioinks
natural
and/or
synthetic
polymers
mixtures
with
biological
materials)
printing
methods
extrusion,
digital
light
processing,
coaxial
microfluidic
bioprinting,
etc.)
incorporated
various
bioactive
agents
growth
factors,
antibiotics,
antibacterial
agents,
nanoparticles,
cells
fibroblasts,
keratinocytes,
mesenchymal
stem
cells,
endothelial
etc.).
Burns & Trauma,
Journal Year:
2025,
Volume and Issue:
13
Published: Jan. 1, 2025
Abstract
Effective
wound
management
and
treatment
are
crucial
in
clinical
practice,
yet
existing
strategies
often
fall
short
fully
addressing
the
complexities
of
skin
healing.
Recent
advancements
tissue
engineering
have
introduced
innovative
approaches,
particularly
through
use
nanobiomaterials,
to
enhance
healing
process.
In
this
context,
titanium
dioxide
nanoparticles
(TiO2
NPs)
garnered
attention
due
their
excellent
biological
properties,
including
antioxidant,
anti-inflammatory,
antimicrobial
properties.
Furthermore,
these
can
be
modified
therapeutic
benefits.
Scaffolds
dressings
containing
TiO2
NPs
demonstrated
promising
outcomes
accelerating
enhancing
regeneration.
This
review
paper
covers
process,
properties
that
make
them
suitable
for
promoting
healing,
methods
synthesizing
NPs,
scaffolds
application
potential
toxicity
NPs.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Patients
and
healthcare
systems
face
significant
social
financial
challenges
due
to
the
increasing
number
of
individuals
with
chronic
external
internal
wounds
that
fail
heal.
The
complexity
healing
process
remains
a
serious
health
concern,
despite
effectiveness
conventional
wound
dressings
in
promoting
healing.
Recent
advancements
materials
science
fabrication
techniques
have
led
development
innovative
enhance
To
further
expedite
process,
novel
approaches
such
as
nanoparticles,
3D-printed
dressings,
biomolecule-infused
emerged,
along
cell-based
methods.
Additionally,
gene
therapy
technologies
are
being
harnessed
generate
stem
cell
derivatives
more
functional,
selective,
responsive
than
their
natural
counterparts.
This
review
highlights
potential
biomaterials,
3D
bioprinting,
gene-
therapies
However,
it
also
underscores
necessity
for
research
address
existing
integrate
these
strategies
into
standard
clinical
practice.
Carbohydrate Polymers,
Journal Year:
2023,
Volume and Issue:
321, P. 121298 - 121298
Published: Aug. 14, 2023
Chronic
wounds,
especially
diabetic
ulcers,
pose
a
significant
challenge
in
regenerative
medicine.
Cellulose
derivatives
offer
remarkable
wound
management
properties,
such
as
effective
absorption
and
retention
of
exudates,
maintaining
an
optimal
moisture
environment
crucial
for
successful
chronic
regeneration.
However,
conventional
dressings
have
limited
efficacy
managing
healing
these
types
skin
lesions,
driving
scientists
to
explore
innovative
approaches.
The
emergence
3D
printing
has
enabled
personalized
that
meet
individual
patient
needs,
improving
the
process
comfort.
demanding
requirements
biocompatibility,
printability,
biofabrication
necessary
biologically
active
scaffolds.
potential
applications
nanocellulose
cellulose
derivative-based
inks
regeneration
remain
largely
unexplored.
Thus,
this
review
provides
comprehensive
overview
recent
advancements
cellulose-based
dressings.
composition
approaches
are
thoroughly
discussed,
including
functionalization
with
bioactive
molecules
antibiotics
improved
Similarly,
vitro
vivo
performance
is
extensively
examined.
In
summary,
aims
highlight
exceptional
advantages
diverse
printed
care.
Regenerative Therapy,
Journal Year:
2023,
Volume and Issue:
24, P. 361 - 376
Published: Sept. 4, 2023
Wounds
are
a
stern
healthcare
concern
in
the
growth
of
chronic
disease
conditions
as
they
can
increase
costs
and
complicate
internal
external
health.
Advancements
current
newer
management
systems
for
wound
healing
should
be
place
to
counter
health
burden
wounds.
Researchers
discovered
that
two-dimensional
(2D)
media
lacks
appropriate
real-life
detection
cellular
matter
these
have
highly
complicated
diverse
structures,
compositions,
interactions.
Hence,
innovation
towards
three-dimensional
(3D)
is
called
conquer
high-level
assessment
characterization
vivo
using
new
technologies.
The
application
modern
dressings
prepared
from
degenerated
natural
tissue,
biodegradable
biopolymer,
synthetic
polymer,
or
composite
materials
currently
an
area
tissue
regeneration
medicine.
Moreover,
integration
3D
printing
nanomaterial
science
promising
approach
with
potential
individualized,
flexible,
precise
technology
care
approaches.
This
review
encompasses
outcomes
various
investigations
on
recent
advances
3D-printed
drug-loaded
natural,
synthetic,
nanomaterials
healing.
challenges
associated
their
fabrication,
clinical
progress,
future
perspectives
also
addressed.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(47)
Published: Nov. 18, 2024
Abstract
Skin
wounds
have
become
an
important
issue
that
affects
human
health
and
burdens
global
medical
care.
Hydrogel
materials
similar
to
the
natural
extracellular
matrix
(ECM)
are
one
of
best
candidates
for
ideal
wound
dressings
most
feasible
choices
printing
inks.
Distinct
from
hydrogels
made
by
traditional
technologies,
which
lack
bionic
mechanical
properties,
3D
can
promptly
accurately
create
with
complex
bioactive
structures
potential
promote
tissue
regeneration
healing.
Herein,
a
comprehensive
review
multi‐functional
printing‐based
hydrogel
healing
is
presented.
The
first
summarizes
techniques
dressings,
including
photo‐curing,
extrusion,
inkjet,
laser‐assisted
printing.
Then,
properties
design
approaches
series
bioinks
composed
natural,
synthetic,
composite
polymers
described.
Thereafter,
application
in
variety
environments
discussed
depth,
hemostasis,
anti‐inflammation,
antibacterial,
skin
appendage
regeneration,
intelligent
monitoring,
machine
learning‐assisted
therapy.
Finally,
challenges
prospects
Biofabrication,
Journal Year:
2023,
Volume and Issue:
16(1), P. 015001 - 015001
Published: Sept. 26, 2023
There
is
a
constant
demand
for
novel
materials/biomedical
devices
to
accelerate
the
healing
of
hard-to-heal
wounds.
Herein,
an
innovative
3D-printed
bioinspired
construct
was
developed
as
antibacterial/regenerative
scaffold
diabetic
wound
healing.
Hyaluronic/chitosan
(HA/CS)
ink
used
fabricate
bilayer
comprising
dense
plain
hydrogel
layer
topping
nanofibrous
obtained
by
incorporating
with
polylactic
acid
microspheres
(MS).
These
were
embedded
nano
ZnO
(ZNP)
or
didecyldimethylammonium
bromide
(DDAB)-treated
ZNP
(D-ZNP)
generate
antibacterial/healing
nano/micro
hybrid
biomaterials,
Z-MS@scaffold
and
DZ-MS@scaffold.
Plain
composite
scaffolds
blank
MS
(blank
MS@scaffold)
MS-free
ZNP@scaffold
D-ZNP@scaffold
comparison.
3D
printed
constructs
customizable
porosity
verified
SEM.
The
DZ-MS@scaffold
exhibited
largest
total
pore
area
well
highest
water-uptake
capacity
andin
vitroantibacterial
activity.
Treatment
ofStaphylococcus
aureus-infected
full
thickness
wounds
in
rats
indicated
superiority
evidenced
multiple
assessments.
afforded
95%
wound-closure,
infection
suppression,
effective
regulation
healing-associated
biomarkers
regeneration
skin
structure
14
d.
On
other
hand,
non-diabetic
acute
effectively
accelerated
simpler
less
porous
Z-MS@scaffold.
Information
provided
first-time
on
printing
using
non-electrospun
injectable
bioactive
particulate
constructs,
ZNP-functionalized
formulation
distinct
bioactivity
D-ZNP
powerful
antibacterial/wound
promotor.
In
addition,
findings
underscored
crucial
role
nanofibrous-MS
carrier
enhancing
physicochemical,
antibacterial,
regenerative
properties
DDAB-nano
ZnO.
conclusion,
merging
MS-boosted
functionalities
DDAB,
structural
characteristics
addition
those
scaffold,
provide
versatile
material
platform
biomedical
applications.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(40), P. 41107 - 41129
Published: Sept. 16, 2024
This
review
examines
the
convergence
of
silver
nanoparticles
(AgNPs),
three-dimensional
(3D)
printing,
and
wound
healing,
focusing
on
significant
advancements
in
these
fields.
We
explore
unique
properties
AgNPs,
notably
their
strong
antibacterial
efficacy
potential
applications
enhancing
recovery.
Furthermore,
delves
into
3D
printing
technology,
discussing
its
core
principles,
various
materials
employed,
recent
innovations.
The
integration
AgNPs
3D-printed
structures
for
regenerative
medicine
is
analyzed,
emphasizing
benefits
this
combined
approach
identifying
challenges
that
must
be
addressed.
comprehensive
overview
aims
to
elucidate
current
state
field
direct
future
research
toward
developing
more
effective
solutions
healing.
