Therapeutic Potential of Microneedle Assisted Drug Delivery for Wound Healing: Current State of the Art, Challenges, and Future Perspective

AAPS PharmSciTech, Год журнала: 2025, Номер 26(1)

Опубликована: Янв. 8, 2025

Язык: Английский

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Peptides in Chronic Wound Healing: Fighting Infections and Facilitating Diabetic Wound Management

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106599 - 106599

Опубликована: Янв. 1, 2025

Язык: Английский

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Phytogenic metal nanoparticles: A promising frontier in natural medicine for inflammation and wound repair

Next research., Год журнала: 2025, Номер unknown, С. 100160 - 100160

Опубликована: Янв. 1, 2025

Язык: Английский

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Enhanced Transdermal Delivery of Piroxicam via Nanocarriers, Formulation, Optimization, Characterization, Animal Studies and Randomized Double-Blind Clinical Trial

AAPS PharmSciTech, Год журнала: 2025, Номер 26(3)

Опубликована: Март 6, 2025

Язык: Английский

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Advanced healing potential of simple natural hydrogel loaded with sildenafil in combating infectious wounds

International Journal of Pharmaceutics X, Год журнала: 2025, Номер unknown, С. 100328 - 100328

Опубликована: Март 1, 2025

Infected wounds are common clinical injuries that often complicated by inflammation and oxidative stress due to bacterial invasion. These typically suffer from impaired vascularization, which delays healing increases the risk of complications such as sepsis chronic wounds. Therefore, developing an effective treatment for infected is highly necessary. Egg white can promote cell regeneration repair, while chitosan in resisting Sildenafil believed have potential angiogenesis. Based on these properties, we prepared a new type hydrogel using egg framework, loaded with sildenafil (CEHS). The combines benefits its components, exhibiting good biocompatibility promoting proliferation migration NIH 3T3 (3T3) cells human umbilical vein endothelial (HUVEC), well angiogenesis HUVEC. It also exhibits significant antioxidant, anti-inflammatory, antibacterial properties against Escherichia coli (E. coli) Staphylococcus aureus (S. aureus). Additionally, mouse model wounds, CEHS effectively promoted wound through excellent antioxidant anti-inflammatory activity, pro-angiogenic effects. In summary, this simple-to-prepare, multifunctional natural shows great promise

Язык: Английский

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Foam-Based Drug Delivery Systems for Skin Disorders: A Comprehensive Review

AAPS PharmSciTech, Год журнала: 2025, Номер 26(4)

Опубликована: Апрель 4, 2025

Язык: Английский

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Comprehensive Developmental Investigation on Simvastatin Enriched Bioactive Film Forming Spray Using the Quality by Design Paradigm: A Prospective Strategy for Improved Wound Healing

Journal of drug targeting, Год журнала: 2024, Номер 32(9), С. 1139 - 1153

Опубликована: Июль 23, 2024

The use of topical antimicrobials in wound healing presents challenges like risk drug resistance and toxicity to local tissue. Simvastatin (SIM), a lipid-lowering agent which reduces the cardiovascular events, is repurposed for its pleiotropic effect healing. A bioactive bioadhesive polymer-based film forming spray (FFS) formulation SIM was designed using chitosan, collagen, hyaluronic acid optimised by employing DoE approach. Optimised demonstrated moderate viscosity (12.5 ± 0.3 cP), rapid formation (231 5.6 s), flexibility, tensile strength sustained release (T80 - time 80% 9.05 0.7 h). Scanning electron microscopy (SEM) verified uniformly dispersed within composite polymer matrix. FFS antimicrobial activity against gram positive negative bacteria.

Язык: Английский

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pH-responsive Mupirocin-loaded Hybrid Nanoparticles in Hydrogel and Film Forming Spray Against Resistant Bacterial Wound Infections.

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 101, С. 106187 - 106187

Опубликована: Сен. 12, 2024

Язык: Английский

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Antimicrobial Peptide Delivery Systems as Promising Tools Against Resistant Bacterial Infections

Antibiotics, Год журнала: 2024, Номер 13(11), С. 1042 - 1042

Опубликована: Ноя. 4, 2024

The extensive use of antibiotics during recent years has led to antimicrobial resistance development, a significant threat global public health. It is estimated that around 1.27 million people died worldwide in 2019 due infectious diseases caused by antibiotic-resistant microorganisms, according the WHO. 700,000 die each year worldwide, which expected rise 10 2050. Therefore, new and efficient antimicrobials against resistant pathogenic bacteria are urgently needed. Antimicrobial peptides (AMPs) present broad spectrum antibacterial effects considered potential tools for developing novel therapies combat infections. However, their clinical application currently limited instability, low selectivity, toxicity, bioavailability, resulting narrow therapeutic window. Here we describe an overview AMPs bacterial infections through nanoformulation. evaluates metal, polymeric, lipid AMP delivery systems as promising treatment infections, offering solution aforementioned limitations.

Язык: Английский

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Advancements of thermoelectric nanomaterials in ROS-mediated broad-spectrum antibacterial therapies for wound healing

Journal of Material Science and Technology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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