Bioelectricity is a universal multifaced signaling cue in living organisms DOI
Guangjun Zhang, Michael Levin

Molecular Biology of the Cell, Год журнала: 2025, Номер 36(2)

Опубликована: Янв. 28, 2025

The cellular electrical signals of living organisms were discovered more than a century ago and have been extensively investigated in the neuromuscular system. Neuronal depolarization hyperpolarization are essential for our physiological pathological functions. Bioelectricity is being recognized as an ancient, intrinsic, fundamental property all cells, it not limited to Instead, emerging evidence supports view bioelectricity instructional signaling cue physiology, embryonic development, regeneration, human diseases, including cancers. Here, we highlight current understanding share views on challenges perspectives.

Язык: Английский

Injury minimization after myocardial infarction: focus on extracellular vesicles DOI
Lucio Barile, Eduardo Marbán

European Heart Journal, Год журнала: 2024, Номер 45(18), С. 1602 - 1609

Опубликована: Фев. 15, 2024

Abstract Despite improvements in clinical outcomes following acute myocardial infarction, mortality remains high, especially patients with severely reduced left ventricular ejection fraction (LVEF <30%), emphasizing the need for effective cardioprotective strategies adjunctive to recanalization. Traditional cell therapy has shown equivocal success, shifting focus innovative cardioactive biologicals and mimetic therapies, particularly extracellular vesicles (EVs). EVs, as carriers of non-coding RNAs other essential biomolecules, influence neighbouring remote function a paracrine manner. Compared therapy, EVs possess several clinically advantageous traits, including stability, ease storage (enabling off-the-shelf readiness), decreased immunogenicity. Allogeneic from mesenchymal and/or cardiac stromal progenitor cells demonstrate safety potential efficacy preclinical settings. This review delves into translational EV-based therapeutic approaches, specifically highlighting findings large-animal studies, offers synopsis ongoing early-stage trials this domain.

Язык: Английский

Процитировано

6
Metabolic Crosstalk between Liver and Brain: From Diseases to Mechanisms DOI Open Access
Xiaoyue Yang,

Kangli Qiu,

Yaoyao Jiang

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7621 - 7621

Опубликована: Июль 11, 2024

Multiple organs and tissues coordinate to respond dietary environmental challenges. It is interorgan crosstalk that contributes systemic metabolic homeostasis. The liver brain, as key organs, have their unique dialogue transmit messages. interconnected pathogenesis of brain implicated in numerous neurodegenerative disorders. Recent insights positioned the not only a central hub but also an endocrine organ, capable secreting hepatokines signals throughout body via bloodstream. Metabolites from or gut microbiota facilitate complex between brain. In parallel humoral factors, neural pathways, particularly hypothalamic nuclei autonomic nervous system, are pivotal modulating bilateral interplay cerebral hepatic compartments. term “liver–brain axis” vividly portrays this interaction. At end review, we summarize cutting-edge technical advancements enabled observation manipulation these signals, including genetic engineering, molecular tracing, delivery technologies. These innovations paving way for deeper understanding liver–brain axis its role

Язык: Английский

Процитировано

6
Extracellular vesicles in cardiovascular diseases: From pathophysiology to diagnosis and therapy DOI
Yuxin Du, Lin Wu, Litao Wang

и другие.

Cytokine & Growth Factor Reviews, Год журнала: 2023, Номер 74, С. 40 - 55

Опубликована: Сен. 28, 2023

Язык: Английский

Процитировано

15
Fatty acids in cancer: Metabolic functions and potential treatment DOI Creative Commons
Ao Du, Zhen Wang, Tengda Huang

и другие.

MedComm – Oncology, Год журнала: 2023, Номер 2(1)

Опубликована: Март 1, 2023

Abstract Lipid metabolic reprogramming is one of the important characteristics cancer cells. As major components lipids, fatty acids provide energy and material basis for cell survival. Abnormal acid metabolism has been found in many cancers. Fatty uptake, transport, synthesis are closely related to pathogenesis cancer. Meanwhile, changes membrane structure cells signal transduction mediated by signaling lipids also helping survive changing microenvironment. Some these enzymes metabolites involved emerging as unique biomarkers. Multiple studies have shown that disordered can regulate tumor proliferation, metastasis, drug resistance. Therefore, targeting become a promising treatment strategy. Here, we mainly present alterations acids, basic We discuss based on metabolism. These may better understanding lipid cancer, new ideas biomarker search, development, combination therapy.

Язык: Английский

Процитировано

14
Extracellular Vesicles in Breast Cancer: From Intercellular Communication to Therapeutic Opportunities DOI Creative Commons
Muttiah Barathan, Sook Luan Ng, Yogeswaran Lokanathan

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(5), С. 654 - 654

Опубликована: Май 14, 2024

Breast cancer, a multifaceted and heterogeneous disease, poses significant challenges in terms of understanding its intricate resistance mechanisms devising effective therapeutic strategies. This review provides comprehensive overview the landscape extracellular vesicles (EVs) context breast highlighting their diverse subtypes, biogenesis, roles intercellular communication within tumour microenvironment (TME). The discussion spans various aspects, from EVs stromal cells cancer to influence on angiogenesis, immune response, chemoresistance. impact EV production different culture systems, including two dimensional (2D), three (3D), organoid models, is explored. Furthermore, this delves into potential presenting emerging strategies such as engineered for gene delivery, nanoplatforms targeted chemotherapy, disrupting derived treatment approach. Understanding these complex interactions milieu crucial identifying developing new targets.

Язык: Английский

Процитировано

5
Exosome-derived microRNAs: emerging players in vitiligo DOI Creative Commons

Wenquan li,

Yaobin Pang,

Qingying He

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июль 8, 2024

Exosome-derived microRNAs (miRNAs) are biomacromolecules and nanoscale extracellular vesicles originating from intracellular compartments that secreted by most cells into the space. This review examines formation function of exosomal miRNAs in biological information transfer, explores pathogenesis vitiligo, highlights relationship between vitiligo. The aim is to deepen understanding how influence immune imbalance, oxidative stress damage, melanocyte-keratinocyte interactions, melanogenesis disorders development enhanced may contribute potential diagnostic therapeutic options for

Язык: Английский

Процитировано

5
Roles of extracellular vesicles in ageing-related chronic kidney disease: Demon or angel DOI Creative Commons
Siqi Yin, Zixuan Zhou,

Peiwen Fu

и другие.

Pharmacological Research, Год журнала: 2023, Номер 193, С. 106795 - 106795

Опубликована: Май 19, 2023

Ageing is a universal and unavoidable phenomenon that significantly increases the risk of developing chronic kidney disease (CKD). It has been reported ageing associated with functional disruption structural damage to kidneys. Extracellular vesicles (EVs), which are nanoscale membranous containing lipids, proteins, nucleic acids, secreted by cells into extracellular spaces. They have diverse functions such as repairing regenerating different forms ageing-related CKD playing crucial role in intercellular communication. This paper reviews etiology CKD, particular attention paid roles EVs carriers signals anti-ageing therapeutic strategies CKD. In this regard, double-edged examined, along potential for their application clinical settings.

Язык: Английский

Процитировано

12
A proteomic meta-analysis refinement of plasma extracellular vesicles DOI Creative Commons

Milene C. Vallejo,

Soumyadeep Sarkar, Emily C. Elliott

и другие.

Scientific Data, Год журнала: 2023, Номер 10(1)

Опубликована: Ноя. 28, 2023

Abstract Extracellular vesicles play major roles in cell-to-cell communication and are excellent biomarker candidates. However, studying plasma extracellular is challenging due to contaminants. Here, we performed a proteomics meta-analysis of public data refine the EV composition by separating proteins contaminants into different clusters. We obtained two clusters with total 1717 that were depleted known enriched markers independently validated 71% true-positive. These had 133 differentiation (CD) antigens from signaling. compared our deposited PeptideAtlas, making refined protein list resource for mechanistic studies. As use case example this resource, type 1 diabetes proplatelet basic EVs showed it regulates apoptosis β cells macrophages, key players disease development. Our approach provides refinement scientific community.

Язык: Английский

Процитировано

12
NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a “One-Stone-Two-Birds” manner DOI Creative Commons
Guanghao Wu, Qihang Su, Jie Li

и другие.

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Янв. 5, 2023

Tendinopathy is the leading sports-related injury and will cause severe weakness tenderness. Effective therapy for tendinopathy remains limited, extracellular vesicles (EVs) derived from adipose tissue-derived mesenchymal stem cells (ADMSCs) have demonstrated great potential in treatment; however, influence of aging status on EV treatment has not been previously described.In this study, it was found that ADMSCs old mice (ADMSCold) remarkable cellular senescence impaired NAD+ metabolism compared with young (ADMSCyoung). Lower NAMPT contents were detected both ADMSCold its secreted EVs (ADMSCold-EVs). Advanced animal experiments ADMSCyoung-EVs, but ADMSCold-EVs, alleviated pathological structural, functional biomechanical properties mice. Mechanistic analyses ADMSCyoung-EVs improved cell viability relieved tenocytes through NAMPT/SIRT1/PPARγ/PGC-1α pathway. promoted phagocytosis M2 polarization macrophages NAMPT/SIRT1/Nf-κb p65/NLRP3 The macrophage/tenocyte crosstalk influenced by ADMSCyoung-EV thus "One-Stone-Two-Birds" effects treatment.This study demonstrates an effective novel uncovers donor age curative clarifying detailed biological mechanism.

Язык: Английский

Процитировано

11
Adipose tissue macrophage–derived microRNA-210-3p disrupts systemic insulin sensitivity by silencing GLUT4 in obesity DOI Creative Commons
Debarun Patra, Palla Ramprasad, Shivam Sharma

и другие.

Journal of Biological Chemistry, Год журнала: 2024, Номер 300(6), С. 107328 - 107328

Опубликована: Апрель 26, 2024

Management of chronic obesity-associated metabolic disorders is a key challenge for biomedical researchers. During obesity, visceral adipose tissue (VAT) undergoes substantial transformation characterized by unique lipid-rich hypoxic AT microenvironment (ATenv) which plays crucial role in VAT dysfunction, leading to insulin resistance (IR) and type 2 diabetes(T2D). Here, we demonstrate that obese ATenv triggers the release miR-210-3p microRNA-loaded extracellular vesicles (EVs) from macrophages (ATMs), disseminate neighboring adipocytes, skeletal muscle cells, hepatocytes through paracrine endocrine actions, thereby influencing sensitivity. Moreover, EVs collected Dicer-silenced miR-210-3p-overexpressed bone marrow-derived (BMDMs), induce glucose intolerance IR lean mice. Mechanistically, interacts with 3′-UTR GLUT4 mRNA silences its expression, compromising cellular uptake Therapeutic inhibition notably rescues high-fat diet (HFD)-fed mice obesity-induced systemic intolerance. Thus, targeting ATM-specific during obesity could be promising strategy managing T2D.

Язык: Английский

Процитировано

4