Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention

Reviews in Endocrine and Metabolic Disorders, Год журнала: 2019, Номер 21(1), С. 127 - 147

Опубликована: Дек. 3, 2019

Язык: Английский

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Functional Hypothalamic Amenorrhea: An Endocrine Society Clinical Practice Guideline

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2017, Номер 102(5), С. 1413 - 1439

Опубликована: Март 22, 2017

The American Society for Reproductive Medicine, the European of Endocrinology, and Pediatric Endocrine Society. This guideline was funded by To formulate clinical practice guidelines diagnosis treatment functional hypothalamic amenorrhea (FHA). participants include an Society–appointed task force eight experts, a methodologist, medical writer. evidence-based developed using Grading Recommendations, Assessment, Development, Evaluation approach to describe strength recommendations quality evidence. commissioned two systematic reviews used best available evidence from other published individual studies. One group meeting, several conference calls, e-mail communications enabled consensus. committees members cosponsoring organizations reviewed commented on preliminary drafts this guideline. FHA is form chronic anovulation, not due identifiable organic causes, but often associated with stress, weight loss, excessive exercise, or combination thereof. Investigations should assessment systemic endocrinologic etiologies, as exclusion. A multidisciplinary necessary, including medical, dietary, mental health support. Medical complications include, among others, bone loss infertility, appropriate therapies are under debate investigation.

Язык: Английский

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Acute Toxicity, Teratogenic, and Estrogenic Effects of Bisphenol A and Its Alternative Replacements Bisphenol S, Bisphenol F, and Bisphenol AF in Zebrafish Embryo-Larvae

Environmental Science & Technology, Год журнала: 2017, Номер 51(21), С. 12796 - 12805

Опубликована: Окт. 10, 2017

Bisphenol A (BPA), a chemical incorporated into plastics and resins, has estrogenic activity is associated with adverse health effects in humans wildlife. Similarly structured BPA analogues are widely used but far less known about their potential toxicity or vivo. We undertook the first comprehensive analysis on teratogenic of bisphenols BPA, BPS, BPF, BPAF zebrafish embryo-larvae an assessment mechanisms estrogen-responsive transgenic fish Tg(ERE:Gal4ff)(UAS:GFP). The rank order for was > BPF BPS. Developmental deformities larval exposures included cardiac edema, spinal malformation, craniofacial there were distinct differences potencies between different bisphenol chemicals. These effects, however, occurred only at concentrations 1.0 200 mg/L which exceed those most environments. All compounds induced responses Tg(ERE:Gal4ff)(UAS:GFP) that inhibited by coexposure ICI 182 780, demonstrating estrogen receptor dependent mechanism. Target tissues heart, liver, somite muscle, fins, corpuscles Stannius. estrogenicity = Bioconcentration factors 4.5, 17.8, 5.3, 0.067 exposure 1.0, 0.10, 50 BPAF, respectively. thus show these alternatives induce similar toxic to more potent than further highlighting concerns regarding use alternatives.

Язык: Английский

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Estrogens in Male Physiology

Physiological Reviews, Год журнала: 2017, Номер 97(3), С. 995 - 1043

Опубликована: Май 25, 2017

Estrogens have historically been associated with female reproduction, but work over the last two decades established that estrogens and their main nuclear receptors (ESR1 ESR2) G protein-coupled estrogen receptor (GPER) also regulate male reproductive nonreproductive organs. 17β-Estradiol (E2) is measureable in blood of men males other species, rete testis fluids, E2 reaches concentrations normally found only females some species nanomolar estrone sulfate are semen. Aromatase, which converts androgens to estrogens, expressed Leydig cells, seminiferous epithelium, Early studies showed binding numerous tissues, ESR1 ESR2 each show unique distributions actions males. Exogenous treatment produced pathologies laboratory animals men, especially during development, transgenic mice compromised signaling demonstrated an role normal physiology. Efferent ductules epididymal functions dependent on through ESR1, whose loss impaired ion transport water reabsorption, resulting abnormal sperm. Loss or aromatase produces effects targets such as brain, adipose, skeletal muscle, bone, cardiovascular, immune tissues. Expression GPER extensive tracts, suggesting a possible for this reproduction. Recent evidence indicates membrane has critical roles Thus important physiological regulators males, future may reveal additional various target

Язык: Английский

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Exposure to endocrine disruptors during adulthood: consequences for female fertility

Journal of Endocrinology, Год журнала: 2017, Номер 233(3), С. R109 - R129

Опубликована: Март 30, 2017

Endocrine disrupting chemicals are ubiquitous that exhibit endocrine properties in both humans and animals. Female reproduction is an important process, which regulated by hormones susceptible to the effects of exposure chemicals. Disruptions female reproductive functions may result subfertility, infertility, improper hormone production, estrous menstrual cycle abnormalities, anovulation, early senescence. This review summarizes a variety synthetic on fertility during adult life. The covered this pesticides (organochlorines, organophosphates, carbamates, pyrethroids, triazines), heavy metals (arsenic, lead, mercury), diethylstilbesterol, plasticizer alternatives (di-(2-ethylhexyl) phthalate bisphenol A alternatives), 2,3,7,8-tetrachlorodibenzo-p-dioxin, nonylphenol, polychlorinated biphenyls, triclosan, parabens. focuses hypothalamus, pituitary, ovary, uterus because together they regulate normal onset literature shows several have abilities females life, causing abnormalities

Язык: Английский

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Endocrine Disrupting Chemicals: Effects on Endocrine Glands

Frontiers in Endocrinology, Год журнала: 2019, Номер 10

Опубликована: Март 21, 2019

In recent years endocrine disrupting chemicals have gained interest in human physiopathology and more studies aimed to explain how these compounds affect system. populations, the majority of point towards an association between exposure disorders affecting axis. A great number seems be able interfere with physiology hypothalamus-pituitary-gonadal axis; however, every axis may a target for each EDCs their action is not limited single or organ. Several also negative impact on energy metabolic homeostasis altering adipose tissue promoting obesity, syndrome, diabetes. Different mechanism been proposed associations but complexity together degree occupational environmental exposure, low standardization studies, presence confounding factors prevented establish causal relationship specific toxicants so far. This manuscript aim review state art scientific literature regarding effects endocrine-disrupting

Язык: Английский

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Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases

Frontiers in Public Health, Год журнала: 2020, Номер 8

Опубликована: Сен. 24, 2020

The exponential growth of pollutant discharges into the environment due to increasing industrial and agricultural activities is a rising threat for human health biggest concern environmental globally. Several synthetic chemicals, categorized as potential endocrine-disrupting chemicals (EDCs), are evident affect not only livestock wildlife but also humankind. In recent years, exposure EDCs has received increased awareness their association with altered documented by several epidemiological experimental studies. associated deleterious effects on male female reproductive health; causes diabetes, obesity, metabolic disorders, thyroid homeostasis increase risk hormone-sensitive cancers. Sewage effluents major source EDCs, which eventually reach large water bodies potentially contaminate drinking supply. Similarly, storage material such different types plastics leaches out in Water. Domestic wastewater containing pharmaceutical ingredients, metals, pesticides personal care product additives influences endocrine activity. These act via various receptors through variety known unknown mechanisms including epigenetic modification. They differ from classic toxins ways low-dose effect, non-monotonic dose trans-generational effects. This review aims highlight hidden burden discusses non-classical toxic properties an attempt understand magnitude exposome health. Present data advocate that there may be associations between undesirable outcomes warrants further bio-monitoring EDCs.

Язык: Английский

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Exposure to endocrine-disrupting chemicals in the USA: a population-based disease burden and cost analysis

The Lancet Diabetes & Endocrinology, Год журнала: 2016, Номер 4(12), С. 996 - 1003

Опубликована: Окт. 19, 2016

Язык: Английский

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Developmental origins of metabolic diseases

Physiological Reviews, Год журнала: 2020, Номер 101(3), С. 739 - 795

Опубликована: Дек. 3, 2020

Almost 2 billion adults in the world are overweight, and more than half of them classified as obese, while nearly one-third children globally experience poor growth development. Given vast amount knowledge that has been gleaned from decades research on development, a number questions remain to why is now midst global epidemic obesity accompanied by "double burden malnutrition," where overweight coexists with underweight micronutrient deficiencies. This challenge human condition can be attributed nutritional environmental exposures during pregnancy may program fetus have higher risk chronic diseases adulthood. To explore this concept, frequently called developmental origins health disease (DOHaD), review considers host factors physiological mechanisms drive or child toward obesity, fatty liver disease, hypertension, and/or type diabetes (T2D). end, explores epidemiology DOHaD discussions focused adaptations energetics, placental dysmetabolism, key act promote These areas complementary additive understanding how providing best conditions for optimal create possible lifelong health. Moreover, both well epigenetic molecular vital most fully address issues other diseases.

Язык: Английский

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Environmental Obesogens: Mechanisms and Controversies

The Annual Review of Pharmacology and Toxicology, Год журнала: 2018, Номер 59(1), С. 89 - 106

Опубликована: Июль 25, 2018

Obesity is a worldwide pandemic in adults as well children and adds greatly to health care costs through its association with type 2 diabetes, metabolic syndrome, cardiovascular disease, cancers. The prevailing medical view of obesity that it results from simple imbalance between caloric intake energy expenditure. However, numerous other factors are important the etiology obesity. obesogen hypothesis proposes environmental chemicals termed obesogens promote by acting increase adipocyte commitment, differentiation, size altering set points or hormonal regulation appetite satiety. Many endocrine disrupting interfere normal regulation. Endocrine abundant our environment, used everyday products food packaging fungicides. In this review, we explore evidence supporting hypothesis, gaps knowledge currently preventing complete understanding extent which contribute pandemic.

Язык: Английский

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