A Self-Adaptive Serious Game to Improve Motor Learning Among Older Adults in Immersive Virtual Reality: Short-Term Longitudinal Pre-Post Study on Retention and Transfer (Preprint) DOI
Gauthier Everard, Louise Declerck, Thierry Lejeune

и другие.

Опубликована: Июль 5, 2024

BACKGROUND Despite their potential, the use of serious games within immersive virtual reality (iVR) for enhancing motor skills in older adults remains relatively unexplored. In this study, we developed a self-adaptive game iVR called REAsmash-iVR. This involves swiftly locating and striking digital mole presented with various distractors. OBJECTIVE short-term longitudinal pre-post study aims to evaluate REAsmash-iVR’s efficacy promoting learning adults. Specifically, seek determine transfer retention achieved through REAsmash-iVR other tasks. METHODS A total 20 participated engaging over 7 consecutive days. The evaluation included tests such as KinematicsVR VR adaptation Box Block Test (BBT-VR). tasks drawing straight lines circles fast accurately possible, while BBT-VR required participants move cubes quickly possible 60 seconds. Assessments were conducted before after intervention, follow-up at 1 week post intervention. primary outcome focused on evaluating impact speed-accuracy trade-off during Secondary outcomes analyzing movement smoothness, measured by spectral arc length, scores. RESULTS Results revealed significant improvements intervention compared that notable (t<sub>19</sub>=5.46; <i>P</i><.001; Cohen <i>d</i>=1.13) circle (t<sub>19</sub>=3.84; <i>P</i>=.001; <i>d</i>=0.787). Likewise, there was enhancement particularly (<i>χ</i>²<sub>2</sub>=11.2; <i>P</i>=.004; ε<sup>2</sup>=0.23), but not straight-line (<i>χ</i>²<sub>2</sub>=2.1; <i>P</i>=.35; ε<sup>2</sup>=0.003). Additionally, demonstrated improvement (<i>q</i>=5.26; <i>r</i>=0.678) (<i>q</i>=6.82; <i>r</i>=0.880) skills. CONCLUSIONS These findings provide perspectives improve delivering targeting cognitive functions. CLINICALTRIAL ClinicalTrials.gov NCT04694833; https://clinicaltrials.gov/study/NCT04694833

Язык: Английский

Neurite density but not myelination of specific fiber tracts links polygenic scores to general intelligence DOI Open Access

Christina Stammen,

Javier Schneider Penate,

Dorothea Metzen

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Abstract White matter is fundamental for efficient and accurate information transfer throughout the human brain thus crucial intelligence. Previous studies often demonstrated associations between fractional anisotropy (FA) as a metric of white “microstructural integrity” intelligence, but it still unclear, whether this relation due to greater axon density, parallel, homogenous fiber orientation distributions, or myelination since all these measures influence FA. Using neurite dispersion density imaging (NODDI) myelin water fraction (MWF) data, we analyzed microstructural architecture intelligence in more detail sample 500 healthy young adults. Furthermore, were interested specific indices play intermediary roles pathway that links genetic disposition phenotype. Thus, conducted first time mediation analyses investigating (NDI), (ODI), MWF 64 tracts mediate effects polygenic scores (PGS GI ) on general By doing so, showed NDI, not ODI was significantly associated with NDI six mediated variability g . These findings are step forward decoding neurogenetic underpinnings they identify relates variation , whereas did not.

Язык: Английский

Процитировано

0
A Self-Adaptive Serious Game to Improve Motor Learning Among Older Adults in Immersive Virtual Reality: Short-Term Longitudinal Pre-Post Study on Retention and Transfer DOI Creative Commons
Gauthier Everard, Louise Declerck, Thierry Lejeune

и другие.

JMIR Aging, Год журнала: 2025, Номер 8, С. e64004 - e64004

Опубликована: Март 3, 2025

Despite their potential, the use of serious games within immersive virtual reality (iVR) for enhancing motor skills in older adults remains relatively unexplored. In this study, we developed a self-adaptive game iVR called REAsmash-iVR. This involves swiftly locating and striking digital mole presented with various distractors. short-term longitudinal pre-post study aims to evaluate REAsmash-iVR's efficacy promoting learning adults. Specifically, seek determine transfer retention achieved through REAsmash-iVR other tasks. A total 20 participated engaging over 7 consecutive days. The evaluation included tests such as KinematicsVR VR adaptation Box Block Test (BBT-VR). tasks drawing straight lines circles fast accurately possible, while BBT-VR required participants move cubes quickly possible 60 seconds. Assessments were conducted before after intervention, follow-up at 1 week post intervention. primary outcome focused on evaluating impact speed-accuracy trade-off during Secondary outcomes analyzing movement smoothness, measured by spectral arc length, scores. Results revealed significant improvements intervention compared that notable (t19=5.46; P<.001; Cohen d=1.13) circle (t19=3.84; P=.001; d=0.787). Likewise, there was enhancement particularly (χ²2=11.2; P=.004; ε2=0.23), but not straight-line (χ²2=2.1; P=.35; ε2=0.003). Additionally, demonstrated improvement (q=5.26; r=0.678) (q=6.82; r=0.880) skills. These findings provide perspectives improve delivering targeting cognitive functions. ClinicalTrials.gov NCT04694833; https://clinicaltrials.gov/study/NCT04694833.

Язык: Английский

Процитировано

0
The Relationship Between Grip Strength and Cognitive Impairment: Evidence From NHANES 2011–2014 DOI Creative Commons

Wenyi Nie,

Jingqing Hu

Brain and Behavior, Год журнала: 2025, Номер 15(3)

Опубликована: Март 1, 2025

ABSTRACT Background Prior research has consistently shown an association between muscle strength and various metabolic diseases. However, the relationship cognitive impairment remains elusive. Methods Using data from 2011–2014 National Health Nutrition Examination Survey (NHANES), we investigated impairment. We used multivariate logistic regression, restricted cubic spline regression (RCS), threshold effects to investigate impact of on function. In addition, analyzed correlation in subgroups age, gender, race, education, smoking status, drinking hypertension, diabetes, heart disease. Results 2124 participants were ultimately included for further analysis. Multivariate trend testing, RCS analysis showed a non‐linear negative Threshold effect suggests that when reaches certain value, this undergoes significant changes. three function scoring tests, interaction was only observed racial subgroup. Conclusion This study function, which may have effect. Further longitudinal studies are needed elucidate its potential mechanisms.

Язык: Английский

Процитировано

0
Large-scale functional network connectivity mediate the associations of white matter lesions with executive functions and information processing speed in asymptomatic cerebral small vessels diseases DOI Creative Commons
Jing Chen, Weibing Lu, Shuicheng Yan

и другие.

NeuroImage Clinical, Год журнала: 2025, Номер unknown, С. 103773 - 103773

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Exploring the interrelationship of intra- and inter-network alteration in motor recovery after stroke DOI Creative Commons
Jungsoo Lee, Yun‐Hee Kim

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 15, 2025

Brain networks demonstrate various dynamics during recovery after a stroke. Recovery of interhemispheric interaction and balance the occurrence network reorganization have also been reported stroke recovery. This study aimed to investigate brain At large-scale level, this focuses on determining whether changes in functional period following stroke, along with concurrent connected networks, facilitate Eighty-three subacute ischemic patients participated. All underwent resting-state MRI motor function assessments at two weeks three months onset. Intra- inter-networks from 12 were extracted data. The interrelationship between intra-network values inter-network corresponding other was investigated. good poor subgroups compared. intra- alterations could be observed both groups. more pronounced across multiple group compared group. differences alteration shown diverse sub-networks, including cognitive sensory as well networks. suggests importance adopting plasticity-oriented perspective focused connectivity throughout entire rather than solely emphasizing area for predicting treating

Язык: Английский

Процитировано

0
Timed 25-foot walk test is independently associated with cognitive function in multiple sclerosis: a cross-sectional study DOI Creative Commons
Omid Mirmosayyeb, Saeed Vaheb, Ida Mohammadi

и другие.

European journal of medical research, Год журнала: 2025, Номер 30(1)

Опубликована: Апрель 17, 2025

Cognitive impairment (CI) is prevalent among people with multiple sclerosis (PwMS), significantly affecting their quality of life and functional capacity. While the relationship between CI motor function has been explored in healthy aging other neurological conditions, its association upper lower PwMS remains underexplored. This cross-sectional study analyzed data from 125 (Mage: 37.6 years; median disease duration: 8 years) to examine cognitive outcomes. status was evaluated using Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-Second Edition (CVLT-II), Brief Visuospatial Memory Test-Revised (BVMT-R). Motor assessed 9-Hole Peg (9-HPT) Timed 25-Foot Walk (T25FW). Hierarchical regression models identified significant predictors performance. Multivariate analyses revealed that T25FW strongest predictor SDMT (β = - 3.10, p < 0.001), CVLT-II 2.91, BVMT-R 1.98, 0.001). Additional included duration (SDMT: β 0.26, 0.033; CVLT-II: 0.28, 0.048; BVMT-R: 0.23, 0.037) education (BVMT-R: 0.60, 0.004). EDSS a for 1.42, 0.029). The 9-HPT not independently associated status. emerged as robust processing speed, verbal memory, visuospatial underscoring value practical assessment tool correlating PwMS.

Язык: Английский

Процитировано

0
The influence of eight cognitive training regimes upon cognitive screening tool performance in post-stroke survivors: a network meta-analysis DOI Creative Commons
Liqin Zhou, Xiaofeng Huang,

Jieyu Wang

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Июль 19, 2024

Background Traditional meta-analysis offers only direct comparative evidence. The optimal cognitive training for poststroke impairment (PSCI) remains largely undetermined. Objectives This study aims to assess and compare the effectiveness of selected methods PSCI patients identify rank most effective intervention programs. Methods Searches were conducted in PubMed, Embase, Cochrane Library, Web science, China National Knowledge Infrastructure, Science Technology Journal Database, Wanfang Biomedical Database randomized controlled trials up September 30, 2023. Two researchers independently performed literature screening, data extraction, quality assessment. Network was utilized synthesize main findings. primary outcome focused on intervention’s impact subjective function, with secondary outcomes including effects activities daily living, motor functional independence. is registered PROSPERO (CRD42023463282). Results Fifty eligible identified, revealing eight distinct interventions. These interventions collectively demonstrate efficacy enhancing cognition. significantly improves overall living In Loewenstein Occupational Therapy Cognitive Assessment, Barthel Index, Fugl-Meyer Functional Independence Measure scales, a combination computer-based traditional outperformed conventional control group MD = 29.97 (95%CI: 16.3, 44.2), 18.67 9.78, 27.45), 28.76 5.46, 51.79) 42.2 5.25, 78.99). MMSE scale, virtual reality combined 8.01 3.6, 12.4). On MoCA exercise showed superior results 6.68 2.55, 10.78). Only training, as well alone, enhanced independence, no notable differences other pairwise Conclusion network suggests that augmenting modalities may enhance effectiveness. Specifically, incorporating appear surpass improving cognition, skills, findings this provide evidence-based guidance clinical decision-making. Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO/ , identifier

Язык: Английский

Процитировано

3
The covariant structural and functional neuro-correlates of cognitive impairments in patients with end-stage renal diseases DOI Creative Commons

Yuefan Liu,

Huiying Wang,

Guanchen Sha

и другие.

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Апрель 15, 2024

Introduction Cognitive impairment (CI) is a common complication of end-stage renal disease (ESRD) that associated with structural and functional changes in the brain. However, whether joint alteration pattern exists related to CI ESRD unclear. Methods In this study, instead looking at brain structure function separately, we aim investigate covariant characteristics both aspects. Specifically, took fusion analysis approach, namely, multimodal canonical correlation independent component (mCCA+jICA), jointly study discriminative features gray matter volume (GMV) measured by T1-weighted (T1w) MRI, fractional anisotropy (FA) white diffusion amplitude low-frequency fluctuation (ALFF) blood oxygenation-level-dependent (BOLD) MRI 78 patients versus 64 healthy controls (HCs), followed mediation effect explore relationship between neuroimaging findings, cognitive impairments uremic toxins. Results Two group-discriminative components (ICs) were found show abnormalities across FA, GMV, ALFF (all p &lt; 0.05). The most dominant IC revealed associative patterns alterations GMV (in precentral gyrus, occipital lobe, temporal parahippocampal hippocampus), precuneus, superior parietal gyrus), FA corticospinal tract inferior frontal fasciculus). Another significant dorsolateral prefrontal orbitofrontal cortex) forceps minor). Moreover, identified above-mentioned regions mediate negative serum phosphate mini-mental state examination (MMSE) scores Conclusion mCCA+jICA method was demonstrated be capable revealing neuronal different types as contrasted HCs, may play an important role mediating toxins CIs ESRD. Our results approach provide new insights into similar neurobiological studies.

Язык: Английский

Процитировано

2
Profiles of brain topology for dual-functional stability in old age DOI

Sa Zhou,

Mia Anthony, Ehsan Adeli

и другие.

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

Язык: Английский

Процитировано

1
Association of Age with Dual-Task Objective Cognitive Indicators and Gait Parameters in Older Adults DOI
Linlin Wang, Xuezhen Zhang, Lei Wang

и другие.

Journal of Alzheimer s Disease, Год журнала: 2024, Номер 99(3), С. 993 - 1004

Опубликована: Май 10, 2024

Background: Early recognition of dementia like Alzheimer’s disease is crucial for diagnosis and treatment, existing objective tools early screening cognitive impairment are limited. Objective: To investigate age-related behavioral indicators dual-task performance gait parameters to explore potential markers decline. Methods: The community-based data was analyzed. Hierarchical cluster analysis Pearson correlation were performed on the 9-item subjective decline (SCD-9) scores, walking-cognitive performance, walking speed, 152 participants. significant differences that may related statistically analyzed across six age groups. A mathematical model with as independent variable motor cognition composite score dependent established observe trend age. Results: Strong found between scores SCD Gait mean value ankle angle, left-right difference rate angle knee coefficient variation cycle showed an excellent Motor a decreasing slope after 50 years (k = –1.06) times higher than before –0.18). Conclusions: Cognitive in state promising could characterize

Язык: Английский

Процитировано

0