Aging and cancer
Molecular Cancer,
Год журнала:
2024,
Номер
23(1)
Опубликована: Май 18, 2024
Abstract
Aging
and
cancer
exhibit
apparent
links
that
we
will
examine
in
this
review.
The
null
hypothesis
aging
coincide
because
both
are
driven
by
time,
irrespective
of
the
precise
causes,
can
be
confronted
with
idea
share
common
mechanistic
grounds
referred
to
as
‘hallmarks’.
Indeed,
several
hallmarks
also
contribute
carcinogenesis
tumor
progression,
but
some
molecular
cellular
characteristics
may
reduce
probability
developing
lethal
cancer,
perhaps
explaining
why
very
old
age
(>
90
years)
is
accompanied
a
reduced
incidence
neoplastic
diseases.
We
discuss
possibility
process
itself
causes
meaning
time-dependent
degradation
supracellular
functions
accompanies
produces
byproduct
or
‘age-associated
disease’.
Conversely,
its
treatment
erode
health
drive
process,
has
dramatically
been
documented
for
survivors
diagnosed
during
childhood,
adolescence,
young
adulthood.
conclude
connected
superior
including
endogenous
lifestyle
factors,
well
bidirectional
crosstalk,
together
render
not
only
risk
factor
an
important
parameter
must
considered
therapeutic
decisions.
Язык: Английский
Consequences of ionizing radiation exposure to the cardiovascular system
Nature Reviews Cardiology,
Год журнала:
2024,
Номер
21(12), С. 880 - 898
Опубликована: Июль 10, 2024
Язык: Английский
Biological effects of high-LET irradiation on the circulatory system
International Journal of Radiation Biology,
Год журнала:
2025,
Номер
unknown, С. 1 - 24
Опубликована: Март 10, 2025
High-linear
energy
transfer
(LET)
radiation
is
generally
thought
to
be
more
biologically
effective
in
various
tissues
than
low-LET
radiation,
but
whether
this
also
applies
the
circulatory
system
remains
unclear.
We
therefore
reviewed
biological
studies
about
effects
of
high-LET
on
system.
identified
76
relevant
papers
(24
vitro,
2
ex
vivo,
51
one
overlapping).
In
vitro
used
human,
bovine,
porcine
or
chick
vascular
endothelial
cells
cardiomyocytes,
while
vivo
hearts.
mice,
rats,
rabbits,
dogs
pigs.
The
types
were
neutrons,
α
particles,
heavy
ions
and
negative
pions.
Most
a
single
dose,
although
some
investigated
fractionation
effects.
Twenty-one
estimated
relative
effectiveness
(RBE)
that
ranged
from
0.1
130,
depending
quality
endpoint.
A
meta-analysis
6
8
(selected
based
feasibility
estimating
RBE
its
uncertainty)
suggested
an
6.69
(95%
confidence
intervals
(CI):
2.51,
10.88)
for
1.14
CI:
0.91,
1.37)
studies.
these
14
yielded
2.88
1.52,
4.25).
This
suggests
only
slightly
substantial
inter-study
heterogeneity
complicates
interpretation.
Therapeutic
have
been
reported
disease
models.
Further
research
needed
better
understand
cardiovascular
improve
protection.
Язык: Английский
Clonal hematopoiesis of indeterminate potential: recent developments and perspectives
Current Opinion in Hematology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Purpose
of
review
This
encompasses
the
recently
published
information
on
clonal
hematopoiesis
indeterminate
potential
(CHIP)
and
discusses
its
future
prospects.
By
announcing
advances
in
research
CHIP
risk
factors
related
diseases,
with
purpose
offering
new
insights
to
treat
both
hematologic
nonhematologic
disorders.
Recent
findings
The
majority
studies
have
shown
that
is
a
common
biological
condition
associated
aging
incidence
increases
age.
pathophysiology
blood
diseases
projected
be
significantly
influenced
by
CHIP.
Nevertheless,
increasing
expanded
application
cover
such
as
cardiovascular,
renal,
liver,
pulmonary
diseases.
Furthermore,
fast
advancement
genetic
testing
technology
preventive
medicine,
involvement
variety
disorders
shows
promise
an
essential
target
for
preventing
disease
onset
progression.
Summary
linked
illnesses
has
significant
influence
individual's
health
outlook.
Thus,
identifying
managing
critical
improving
clinical
results
individuals
concerned.
Язык: Английский