Antimicrobial Peptides from Frogs of the Glandirana Genus DOI Creative Commons

Frederick Harris,

David A. Phoenix,

Sarah R. Dennison

и другие.

Biologics, Год журнала: 2024, Номер 4(4), С. 444 - 507

Опубликована: Дек. 8, 2024

Glandirana is a genus of frogs that includes G. rugosa, emeljanovi, minima, tientaiensis, susurra, nakamurai and reliquia. These produce antimicrobial peptides (AMPs), which are endogenous antibiotics possess antibacterial, antifungal, antiviral anti-endotoxin activity help keep the hosts free from infections. In these activities, microbial death promoted by membranolytic mechanisms mediated cationic charge amphiphilic α-helical structures peptides. general, selective for microbes, showing low levels hemolytic cytotoxic activity, as well possessing other biological including anticancer, antioxidative insulinotrophic action. this review, brief overview AMPs with focus on those amphibians provided, along phylogeny nomenclature genus. This review then provides comprehensive, in-depth description activities all produced known period 1994 to 2024. detailed discussion structure/function relationships involved in membrane interactions drive comparisons between same frog across Based their properties, have been proposed investigation potential therapeutic agents, such treatment cancers diabetes, agents areas, crop protection, food industry oral hygiene.

Язык: Английский

IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission DOI Creative Commons
Arun Prakash,

Florence Fenner,

Biswajit Shit

и другие.

PLoS Pathogens, Год журнала: 2024, Номер 20(6), С. e1012308 - e1012308

Опубликована: Июнь 10, 2024

Invertebrates lack the immune machinery underlying vertebrate-like acquired immunity. However, in many insects past infection by same pathogen can ‘prime’ response, resulting improved survival upon reinfection. Here, we investigated mechanistic basis and epidemiological consequences of innate priming fruit fly Drosophila melanogaster when infected with gram-negative bacterial Providencia rettgeri . We find that response to P is a long-lasting sexually dimorphic response. further explore it has potential curtail transmission reducing shedding spread. The enhanced individuals previously exposed non-lethal inoculum coincided transient decrease loads, provide strong evidence effect requires IMD-responsive antimicrobial-peptide Diptericin-B fat body. Further, show while Diptericin B main effector clearance, not sufficient for priming, which regulation IMD peptidoglycan recognition proteins. This work underscores plasticity complexity invertebrate responses infection, providing novel experimental effects on population-level outcomes.

Язык: Английский

Процитировано

7
Metabolism and immune memory in invertebrates: are they dissociated? DOI Creative Commons

Texca T. Méndez-López,

Julio César Carrero, Humberto Lanz‐Mendoza

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июль 11, 2024

Since the discovery of specific immune memory in invertebrates, researchers have investigated its response to diverse microbial and environmental stimuli. Nevertheless, extent system’s interaction with metabolism, remains relatively enigmatic. In this mini review, we propose a comprehensive investigation into intricate interplay between metabolism memory. Our hypothesis is that cellular endocycles epigenetic modifications play pivotal roles shaping relationship. Furthermore, underscore importance crosstalk for understanding evolutionary costs. By evaluating these costs, can gain deeper insights adaptive strategies employed by invertebrates pathogenic challenges. Lastly, outline future research directions aimed at unraveling These avenues inquiry promise illuminate fundamental principles governing host-pathogen interactions trade-offs, thus advancing our invertebrate immunology.

Язык: Английский

Процитировано

4
β-1,3-Glucan Recognition Protein Can Inhibit the Proliferation of Bombyx mori Cytoplasmic Polyhedrosis Virus DOI Creative Commons
Y. Zhang,

Jiming Yan,

Yukai Xie

и другие.

Insects, Год журнала: 2025, Номер 16(4), С. 431 - 431

Опубликована: Апрель 19, 2025

Insects detect pathogens through their germ-line encoded pattern recognition receptors (PRRs). Among these, β-1,3-glucan protein (βGRP) is a crucial PRR that specifically identifies pathogenic microorganisms and triggers innate immune signaling cascades. However, it remains unclear whether βGRP can viruses protect the host from viral threats. In this study, using high-throughput sequencing technology, we observed significant suppression of βGRP-3 in Bombyx mori during infection with cytoplasmic polyhedrosis virus (BmCPV). Moreover, overexpression BmN cell lines resulted reduction BmCPV proliferation, whereas knockdown cells promoted proliferation. These findings suggest family functions not only as anti-bacterial, antifungal, anti-yeast PRRs but also protectors against various harmful insects.

Язык: Английский

Процитировано

0
From Biomphalaria glabrata to Drosophila melanogaster and Anopheles gambiae: the diversity and role of FREPs and Dscams in immune response DOI Creative Commons
Hongyu Li, Qingzhi Zhao, Jialu Xu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 30, 2025

Fibrinogen-related proteins (FREPs) and Down syndrome cell adhesion molecules (Dscams) are important immune-related in invertebrates. Although they found different taxonomic groups possess unique functions, both exhibit high diversity adaptability. FREPs characterized by their fibrinogen-related domains have been primarily studied mollusks, such as Biomphalaria glabrata . Through mechanisms of generation, gene conversion point mutations, Bg FREP plays a critical role the host’s defense against parasites. Dscams immunoglobulin-like transmembrane proteins, mainly arthropods, Drosophila melanogaster Anopheles gambiae alternative splicing, generate multiple isoforms that participate pathogen recognition precise wiring neural circuits. In D. , Dm Dscam not only neuronal self-recognition but also recognition. A. Ag defends parasite infections, binding to pathogens mediating phagocytosis. This paper highlights key roles immunity two major invertebrate groups—mollusks arthropods—and summarizes main advancements current research. These studies deepen understanding immune lay solid foundation for future exploration potential applications biomedical field.

Язык: Английский

Процитировано

0
Candida albicans infection model in Drosophila melanogaster suggests a strain-specific virulent factor boosting a stormy innate immune response DOI Creative Commons

Mariona Cortacans,

Marta Arch, Esther Fuentes

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Окт. 31, 2024

Pathogens drive the evolution of host defence strategies, with both innate and adaptive immune systems playing key roles. Priming enhances system's readiness by functionally reprogramming cells after initial exposure to stimuli, like β-glucans. In this sense,

Язык: Английский

Процитировано

1
IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission DOI Creative Commons
Arun Prakash,

Florence Fenner,

Biswajit Shit

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Фев. 23, 2023

Abstract Invertebrates lack the immune machinery underlying vertebrate-like acquired immunity. However, in many insects past infection by same pathogen can ‘prime’ response, resulting improved survival upon reinfection. Here, we investigated generality, specificity and mechanistic basis of innate priming fruit fly Drosophila melanogaster when infected with gram-negative bacterial Providencia rettgeri . We find that response to P. is a long-lasting pathogen-specific response. further explore epidemiological consequences it has potential curtail transmission reducing shedding spread. The enhanced individuals previously exposed non-lethal inoculum coincided transient decrease loads, provide strong evidence effect requires IMD-responsive antimicrobial-peptide Diptericin-B fat body. Further, show while Diptericin B main effector clearance, not sufficient for priming, which regulation IMD peptidoglycan recognition proteins. This work underscores plasticity complexity invertebrate responses infection, providing novel experimental effects on population-level outcomes.

Язык: Английский

Процитировано

2
Antimicrobial Peptides from Frogs of the Glandirana Genus DOI Creative Commons

Frederick Harris,

David A. Phoenix,

Sarah R. Dennison

и другие.

Biologics, Год журнала: 2024, Номер 4(4), С. 444 - 507

Опубликована: Дек. 8, 2024

Glandirana is a genus of frogs that includes G. rugosa, emeljanovi, minima, tientaiensis, susurra, nakamurai and reliquia. These produce antimicrobial peptides (AMPs), which are endogenous antibiotics possess antibacterial, antifungal, antiviral anti-endotoxin activity help keep the hosts free from infections. In these activities, microbial death promoted by membranolytic mechanisms mediated cationic charge amphiphilic α-helical structures peptides. general, selective for microbes, showing low levels hemolytic cytotoxic activity, as well possessing other biological including anticancer, antioxidative insulinotrophic action. this review, brief overview AMPs with focus on those amphibians provided, along phylogeny nomenclature genus. This review then provides comprehensive, in-depth description activities all produced known period 1994 to 2024. detailed discussion structure/function relationships involved in membrane interactions drive comparisons between same frog across Based their properties, have been proposed investigation potential therapeutic agents, such treatment cancers diabetes, agents areas, crop protection, food industry oral hygiene.

Язык: Английский

Процитировано

0