Behavioral and transcriptional effects of carnosine in the central ring ganglia of the pond snail Lymnaea stagnalis DOI Creative Commons
Veronica Rivi, Giuseppe Caruso, Filippo Caraci

и другие.

Journal of Neuroscience Research, Год журнала: 2024, Номер 102(8)

Опубликована: Июль 30, 2024

Carnosine is a naturally occurring endogenous dipeptide with well-recognized anti-inflammatory, antioxidant, and neuroprotective effects at the central nervous system level. To date, very few studies have been focused on ability of carnosine to rescue and/or enhance memory. Here, we used well-known invertebrate model system, pond snail Lymnaea stagnalis, well-studied associative learning procedure, operant conditioning aerial respiration, investigate long-term memory (LTM) formation reverse obstruction caused by an immune challenge (i.e., lipopolysaccharide [LPS] injection). Exposing snails 1 mM for h before training in addition enhancing resulted significant upregulation expression levels key neuroplasticity genes glutamate ionotropic receptor N-methyl-d-aspartate [NMDA]-type subunit 1-LymGRIN1, transcription factor cAMP-response element-binding protein 1-LymCREB1) snails' ring ganglia. Moreover, pre-exposure LPS injection reversed deficit brought about inflammation, preventing targets stress response Toll-like 4-LymTLR4, molluscan defense molecule-LymMDM, heat shock 70-LymHSP70). Our data are thus consistent hypothesis that can positive benefits cognitive be able aversive states induced neuroinflammation.

Язык: Английский

Unraveling lipopolysaccharide-induced behavioral and molecular effects in Lymnaea stagnalis, an emerging model organism for translational neuroscience DOI Creative Commons
Veronica Rivi, Giovanna Rigillo,

Silvia Alboni

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 152, С. 114418 - 114418

Опубликована: Март 15, 2025

Язык: Английский

Процитировано

0
Behavioral and transcriptional effects of carnosine in the central ring ganglia of the pond snail Lymnaea stagnalis DOI Creative Commons
Veronica Rivi, Giuseppe Caruso, Filippo Caraci

и другие.

Journal of Neuroscience Research, Год журнала: 2024, Номер 102(8)

Опубликована: Июль 30, 2024

Carnosine is a naturally occurring endogenous dipeptide with well-recognized anti-inflammatory, antioxidant, and neuroprotective effects at the central nervous system level. To date, very few studies have been focused on ability of carnosine to rescue and/or enhance memory. Here, we used well-known invertebrate model system, pond snail Lymnaea stagnalis, well-studied associative learning procedure, operant conditioning aerial respiration, investigate long-term memory (LTM) formation reverse obstruction caused by an immune challenge (i.e., lipopolysaccharide [LPS] injection). Exposing snails 1 mM for h before training in addition enhancing resulted significant upregulation expression levels key neuroplasticity genes glutamate ionotropic receptor N-methyl-d-aspartate [NMDA]-type subunit 1-LymGRIN1, transcription factor cAMP-response element-binding protein 1-LymCREB1) snails' ring ganglia. Moreover, pre-exposure LPS injection reversed deficit brought about inflammation, preventing targets stress response Toll-like 4-LymTLR4, molluscan defense molecule-LymMDM, heat shock 70-LymHSP70). Our data are thus consistent hypothesis that can positive benefits cognitive be able aversive states induced neuroinflammation.

Язык: Английский

Процитировано

2