Behavioral and transcriptional effects of carnosine in the central ring ganglia of the pond snail Lymnaea stagnalis DOI Creative Commons
Veronica Rivi, Giuseppe Caruso, Filippo Caraci

et al.

Journal of Neuroscience Research, Journal Year: 2024, Volume and Issue: 102(8)

Published: July 30, 2024

Carnosine is a naturally occurring endogenous dipeptide with well-recognized anti-inflammatory, antioxidant, and neuroprotective effects at the central nervous system level. To date, very few studies have been focused on ability of carnosine to rescue and/or enhance memory. Here, we used well-known invertebrate model system, pond snail Lymnaea stagnalis, well-studied associative learning procedure, operant conditioning aerial respiration, investigate long-term memory (LTM) formation reverse obstruction caused by an immune challenge (i.e., lipopolysaccharide [LPS] injection). Exposing snails 1 mM for h before training in addition enhancing resulted significant upregulation expression levels key neuroplasticity genes glutamate ionotropic receptor N-methyl-d-aspartate [NMDA]-type subunit 1-LymGRIN1, transcription factor cAMP-response element-binding protein 1-LymCREB1) snails' ring ganglia. Moreover, pre-exposure LPS injection reversed deficit brought about inflammation, preventing targets stress response Toll-like 4-LymTLR4, molluscan defense molecule-LymMDM, heat shock 70-LymHSP70). Our data are thus consistent hypothesis that can positive benefits cognitive be able aversive states induced neuroinflammation.

Language: Английский

Unraveling lipopolysaccharide-induced behavioral and molecular effects in Lymnaea stagnalis, an emerging model organism for translational neuroscience DOI Creative Commons
Veronica Rivi, Giovanna Rigillo,

Silvia Alboni

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114418 - 114418

Published: March 15, 2025

Language: Английский

Citations

0
Behavioral and transcriptional effects of carnosine in the central ring ganglia of the pond snail Lymnaea stagnalis DOI Creative Commons
Veronica Rivi, Giuseppe Caruso, Filippo Caraci

et al.

Journal of Neuroscience Research, Journal Year: 2024, Volume and Issue: 102(8)

Published: July 30, 2024

Carnosine is a naturally occurring endogenous dipeptide with well-recognized anti-inflammatory, antioxidant, and neuroprotective effects at the central nervous system level. To date, very few studies have been focused on ability of carnosine to rescue and/or enhance memory. Here, we used well-known invertebrate model system, pond snail Lymnaea stagnalis, well-studied associative learning procedure, operant conditioning aerial respiration, investigate long-term memory (LTM) formation reverse obstruction caused by an immune challenge (i.e., lipopolysaccharide [LPS] injection). Exposing snails 1 mM for h before training in addition enhancing resulted significant upregulation expression levels key neuroplasticity genes glutamate ionotropic receptor N-methyl-d-aspartate [NMDA]-type subunit 1-LymGRIN1, transcription factor cAMP-response element-binding protein 1-LymCREB1) snails' ring ganglia. Moreover, pre-exposure LPS injection reversed deficit brought about inflammation, preventing targets stress response Toll-like 4-LymTLR4, molluscan defense molecule-LymMDM, heat shock 70-LymHSP70). Our data are thus consistent hypothesis that can positive benefits cognitive be able aversive states induced neuroinflammation.

Language: Английский

Citations

1