Rhodium-catalysed additive-free carbonylation of benzamides with diethyl dicarbonate as a carbonyl source

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(14), С. 2744 - 2748

Опубликована: Янв. 1, 2024

A rhodium-catalysed carbonylation of benzamides has been developed by employing diethyl dicarbonate as a stable and easy-to-handle carbonyl source.

Язык: Английский

---

Rhodium-Catalyzed Intramolecular Acylation of 2-(Indol-1-yl)-benzoic Acids under Redox-Neutral Conditions

Synlett, Год журнала: 2023, Номер 34(16), С. 1894 - 1898

Опубликована: Май 8, 2023

Abstract We developed a novel access to indoloindolone by rhodium-catalyzed intramolecular acylation of 2-(indol-1-yl)benzoic acids. This reaction proceeds via the in situ formation mixed anhydride under redox-neutral conditions. Preliminary mechanistic investigations revealed that formed participates C–H activation step, which is facilitated RhI catalyst. The utility this was demonstrated large-scale reaction.

Язык: Английский

---

Rhodium-Catalyzed Decarbonylative Intramolecular Arylation of 2-(1H-Indole-1-carbonyl)benzoic Acids

Synlett, Год журнала: 2024, Номер 35(17), С. 2037 - 2041

Опубликована: Фев. 28, 2024

Abstract We developed a redox-neutral synthesis of isoindoloindolone via intramolecular arylation 2-(1H-indole-1-carbonyl)benzoic acids. This protocol facilitates the formation various substituted isoindoloindolones in yields ranging from 17% to 80%. Our mechanistic investigations indicate pivotal role NaI: iodide anion promotes desired isoindoloindolone, and sodium cation suppresses acylated byproducts, thereby enabling selective acceptable yields.

Язык: Английский

---

Rhodium-catalysed additive-free alkoxycarbonylation of indoles: 2,4,6-trimethylbenzoic acid-based carbonate anhydrides as a versatile alkoxycarboxyl source

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(16), С. 3209 - 3214

Опубликована: Янв. 1, 2024

We developed a rhodium-catalysed alkoxycarbonylation of indoles, characterised by employing stable and easily available 2,4,6-trimethylbenzoic acid-based carbonate anhydrides.

Язык: Английский

---

Rh-Catalyzed Functionalization of N-Heterocycles Through C–H Activation

Topics in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 89 - 157

Опубликована: Янв. 1, 2024

Язык: Английский

---