Hallmarks of Health

Cell, Год журнала: 2020, Номер 184(1), С. 33 - 63

Опубликована: Дек. 18, 2020

Язык: Английский

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The gut–joint axis in rheumatoid arthritis

Nature Reviews Rheumatology, Год журнала: 2021, Номер 17(4), С. 224 - 237

Опубликована: Март 5, 2021

Язык: Английский

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Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier

Journal of Clinical Investigation, Год журнала: 2021, Номер 131(14)

Опубликована: Май 25, 2021

BACKGROUND. Weeks after SARS-CoV-2 infection or exposure, some children develop a severe, life-threatening illness called multisystem inflammatory syndrome in (MIS-C). Gastrointestinal (GI) symptoms are common patients with MIS-C, and severe hyperinflammatory response ensues potential for cardiac complications. The cause of MIS-C has not been identified to date.

Язык: Английский

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Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection

Journal of Advanced Research, Год журнала: 2021, Номер 38, С. 223 - 244

Опубликована: Сен. 17, 2021

Recent research on the implications of gut microbiota brain functions has helped to gather important information relationship between them. Pathogenesis neurological disorders is found be associated with dysregulation gut-brain axis. Some bacteria metabolites are directly increase in reactive oxygen species levels, one most risk factors neurodegeneration. Besides their morbid association, also play a significant role reducing onset these life-threatening disorders.Studies done recent past raises two link and brain: "gut microbiota-oxidative stress-neurodegeneration" microbiota-antioxidant-neuroprotection. This review aims gives deep insight our readers, collective studies done, focusing mediated oxidative stress involved neurodegeneration along focus those showing involvement neuroprotection.This focused three main key concepts. Firstly, mounting evidences from clinical preclinical arenas shows influence resulting dysfunctional processes. Therefore, we describe potential influencing vulnerability stress, budding causative Alzheimer's Parkinson's disease. Secondly, contributing roles been observed attenuating inflammation via its own or by producing secondary and, modulation population antioxidative anti-inflammatory probiotics have shown promising neuro resilience. Thirdly, high throughput silico tools databases correlation microbiome, health, thus providing fascinating perspective new avenues for therapeutic options.

Язык: Английский

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The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation

Frontiers in Nutrition, Год журнала: 2021, Номер 8

Опубликована: Авг. 26, 2021

An increased intestinal permeability has been described in various gastrointestinal and non-gastrointestinal disorders. Nevertheless, the concept definition of is relatively broad includes not only an altered paracellular route, regulated by tight junction proteins, but also transcellular route involving membrane transporters channels, endocytic mechanisms. Paracellular can be assessed vivo using different molecules (e.g., sugars, polyethylene glycols, 51 Cr-EDTA) ex Ussing chambers combining electrophysiology probes molecular sizes. The latter still gold standard technique for assessing epithelial barrier function, whereas techniques, including putative blood biomarkers such as fatty acid-binding protein zonulin, are broadly used despite limitations. In second part review, current evidence role impaired function pathophysiology selected liver diseases discussed. Celiac disease one conditions with best playing a crucial zonulin its proposed regulator. Increased clearly present inflammatory bowel disease, question whether this primary event or consequence inflammation remains unsolved. gut-liver axis increasingly recognized chronic alcoholic metabolic disease. Finally, does support important bile acid diarrhea.

Язык: Английский

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Serum zonulin as a marker of intestinal mucosal barrier function: May not be what it seems

PLoS ONE, Год журнала: 2019, Номер 14(1), С. e0210728 - e0210728

Опубликована: Янв. 14, 2019

The protein, zonulin, has emerged as a popular serological marker to assess the integrity of intestinal mucosal barrier. However, there is limited information on utility serum zonulin indicate gastrointestinal disease and validity detection in widely-used commercial assays. current study reports differences levels across patient groups with dysfunction compared healthy individuals, though methodological inconsistencies indicated that actual protein was not detected by assays applied. nature assays' antigen investigated using immunoprecipitation followed mass spectrometric analysis sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) staining. Top matches included haptoglobin complement C3 for assay manufactured CUSABIO (Wuhan, China) Immundiagnostik AG (Bensheim, Germany). These findings confirm are detecting prehaptoglobin-2. Until methodology improved, we advise greater scientific medical community exercise caution considering measurement barrier integrity.

Язык: Английский

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The intestinal barrier in disorders of the central nervous system

˜The œLancet. Gastroenterology & hepatology, Год журнала: 2022, Номер 8(1), С. 66 - 80

Опубликована: Ноя. 2, 2022

Язык: Английский

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The microbiota–gut–brain axis and neurodevelopmental disorders

Protein & Cell, Год журнала: 2023, Номер 14(10), С. 762 - 775

Опубликована: Май 11, 2023

Abstract The gut microbiota has been found to interact with the brain through microbiota–gut–brain axis, regulating various physiological processes. In recent years, impacts of on neurodevelopment this axis have increasingly appreciated. is commonly considered regulate three pathways, immune pathway, neuronal and endocrine/systemic overlaps crosstalks in between. Accumulating studies identified role neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity Rett Syndrome. Numerous researchers examined pathophysiological mechanisms influenced by (NDDs). This review aims provide a comprehensive overview advancements research pertaining microbiota-gut-brain NDDs. Furthermore, we analyzed both current state progress discuss future perspectives field.

Язык: Английский

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Leaky Gut and the Ingredients That Help Treat It: A Review

Molecules, Год журнала: 2023, Номер 28(2), С. 619 - 619

Опубликована: Янв. 7, 2023

The human body is in daily contact with potentially toxic and infectious substances the gastrointestinal tract (GIT). GIT has most significant load of antigens. can protect intestinal integrity by allowing passage beneficial agents blocking path harmful substances. Under normal conditions, a healthy barrier prevents elements from entering blood stream. However, factors such as stress, an unhealthy diet, excessive alcohol, antibiotics, drug consumption compromise composition microbiota homeostasis function intestine, leading to increased permeability. Intestinal hyperpermeability allow entry through junctions epithelium, which pass into bloodstream affect various organs systems. Thus, leaky gut syndrome dysfunction are associated diseases, inflammatory bowel disease irritable syndrome, well extra-intestinal including heart obesity, type 1 diabetes mellitus, celiac disease. Given relationship between permeability numerous it convenient seek excellent strategy avoid or reduce increase impact dietary nutrients on be crucial for designing new strategies patients pathogenesis gut-related diseases epithelial dysfunctions. In this review article, role functional ingredients suggested mediators disorders.

Язык: Английский

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Mitochondria: It is all about energy

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Апрель 25, 2023

Mitochondria play a key role in both health and disease. Their function is not limited to energy production but serves multiple mechanisms varying from iron calcium homeostasis the of hormones neurotransmitters, such as melatonin. They enable influence communication at all physical levels through interaction with other organelles, nucleus, outside environment. The literature suggests crosstalk between mitochondria circadian clocks, gut microbiota, immune system. might even be hub supporting integrating activity across these domains. Hence, they (missing) link Mitochondrial dysfunction related metabolic syndrome, neuronal diseases, cancer, cardiovascular infectious inflammatory disorders. In this regard, diseases Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS), chronic fatigue syndrome (CFS), pain are discussed. This review focuses on understanding mitochondrial action that allow for maintenance pathways toward dysregulated mechanisms. Although have allowed us adapt changes over course evolution, turn, evolution has shaped mitochondria. Each evolution-based intervention influences its own way. use physiological stress triggers tolerance stressor, achieving adaptability resistance. describes strategies could recover functioning providing comprehensive, root-cause-focused, integrative approach recovering treating people suffering diseases.

Язык: Английский

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