Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases

Frontiers in Microbiology, Год журнала: 2024, Номер 14

Опубликована: Янв. 5, 2024

The imbalance of microbial composition and diversity in favor pathogenic microorganisms combined with a loss beneficial gut microbiota taxa results from factors such as age, diet, antimicrobial administration for different infections, other underlying medical conditions, etc. Probiotics are known their capacity to improve health by stimulating the indigenous microbiota, enhancing host immunity resistance infection, helping digestion, carrying out various functions. Concurrently, metabolites produced these microorganisms, termed postbiotics, which include compounds like bacteriocins, lactic acid, hydrogen peroxide, contribute inhibiting wide range bacteria. This review presents an update on using probiotics managing treating human diseases, including complications that may emerge during or after COVID-19 infection.

Язык: Английский

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Intestinal barrier permeability: the influence of gut microbiota, nutrition, and exercise

Frontiers in Physiology, Год журнала: 2024, Номер 15

Опубликована: Июль 8, 2024

The intestinal wall is a selectively permeable barrier between the content of lumen and internal environment body. Disturbances permeability can potentially lead to unwanted activation enteric immune system due excessive contact with gut microbiota its components, development endotoxemia, when level bacterial lipopolysaccharides increases in blood, causing chronic low-intensity inflammation. In this review, following aspects are covered: structure barrier; influence on via regulation functioning tight junction proteins, synthesis/degradation mucus antioxidant effects; molecular mechanisms pro-inflammatory response caused by invasion through TLR4-induced TIRAP/MyD88 TRAM/TRIF signaling cascades; nutrition permeability, exercise an emphasis exercise-induced heat stress hypoxia. Overall, review provides some insight into how prevent associated inflammatory processes involved many if not most pathologies. Some diets physical supposed be non-pharmacological approaches maintain integrity function provide efficient operation. However, at early age, increased has hormetic effect contributes system.

Язык: Английский

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Border Control: The Role of the Microbiome in Regulating Epithelial Barrier Function

Cells, Год журнала: 2024, Номер 13(6), С. 477 - 477

Опубликована: Март 8, 2024

The gut mucosal epithelium is one of the largest organs in body and plays a critical role regulating crosstalk between resident microbiome host. To this effect, tight control what permitted through barrier high importance. There should be restricted passage harmful microorganisms antigens while at same time allowing absorption nutrients water. An increased permeability, or “leaky gut”, has been associated with variety diseases ranging from infections, metabolic diseases, inflammatory autoimmune to neurological conditions. Several factors can affect including cytokines, dietary components, microbiome. Here, we discuss how impacts permeability epithelial harnessed for therapeutic purposes.

Язык: Английский

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Gut Microbiota and Bacterial Translocation in the Pathogenesis of Liver Fibrosis

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(22), С. 16502 - 16502

Опубликована: Ноя. 19, 2023

Cirrhosis is the end result of liver fibrosis in chronic diseases. Studying mechanisms its development and developing measures to slow down regress it based on this knowledge seem be important tasks for medicine. Currently, disorders gut–liver axis have great importance pathogenesis cirrhosis. However, gut dysbiosis, which manifests as increased proportions microbiota Bacilli Proteobacteria that are capable bacterial translocation a decreased proportion Clostridia strengthen intestinal barrier, occurs even at pre-cirrhotic stage disease. This leads translocation, process by those microbes enter blood portal vein then tissue, where they activate Kupffer cells through Toll-like receptor 4. In response, produce profibrogenic cytokines, hepatic stellate cells, stimulating their transformation into myofibroblasts collagen other elements extracellular matrix. Blocking with antibiotics, probiotics, synbiotics, methods could progression fibrosis. was shown number animal models but requires further verification long-term randomized controlled trials humans.

Язык: Английский

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Impact of Metabolites from Foodborne Pathogens on Cancer

Foods, Год журнала: 2024, Номер 13(23), С. 3886 - 3886

Опубликована: Дек. 1, 2024

Foodborne pathogens are microorganisms that cause illness through contamination, presenting significant risks to public health and food safety. This review explores the metabolites produced by these pathogens, including toxins secondary metabolites, their implications for human health, particularly concerning cancer risk. We examine various such as Salmonella sp., Campylobacter Escherichia coli, Listeria monocytogenes, detailing specific of concern carcinogenic mechanisms. study discusses analytical techniques detecting chromatography, spectrometry, immunoassays, along with challenges associated detection. covers effective control strategies, processing techniques, sanitation practices, regulatory measures, emerging technologies in pathogen control. manuscript considers broader highlighting importance robust policies, awareness, education. identifies research gaps innovative approaches, recommending advancements detection methods, preventive policy improvements better manage foodborne metabolites.

Язык: Английский

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Biomaterials for inflammatory bowel disease: treatment, diagnosis and organoids

Applied Materials Today, Год журнала: 2024, Номер 36, С. 102078 - 102078

Опубликована: Янв. 20, 2024

Язык: Английский

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Effects of Physical Exercise on the Microbiota in Irritable Bowel Syndrome

Nutrients, Год журнала: 2024, Номер 16(16), С. 2657 - 2657

Опубликована: Авг. 11, 2024

Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder characterized by abdominal pain, bloating, diarrhea, and constipation. Recent studies have underscored the significant role of gut microbiota in pathogenesis IBS. Physical exercise, as non-pharmacological intervention, has been proposed to alleviate IBS symptoms modulating microbiota. Aerobic such running, swimming, cycling, shown enhance diversity abundance beneficial bacteria, including Lactobacillus Bifidobacterium. These bacteria produce short-chain fatty acids that possess anti-inflammatory properties support barrier integrity. Studies involving patients participating structured aerobic exercise programs reported improvements their microbiota's composition diversity, alongside an alleviation like pain bloating. Additionally, positively influences mental health reducing stress improving mood, which can further relieve via gut-brain axis. Long-term interventions provide sustained benefits, maintaining stability, supporting immune functions, systemic inflammation. However, must be tailored individual needs avoid exacerbating symptoms. Personalized plans starting with low-to-moderate intensity gradually increasing maximize benefits minimize risks. This review examines impact various types intensities physical on patients, highlighting need for explore optimal protocols. Future research should include larger sample sizes, longer follow-up periods, examine synergistic effects other lifestyle modifications. Integrating into comprehensive management symptom control improve patients' quality life.

Язык: Английский

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Chitosan and its derivatives: A novel approach to gut microbiota modulation and immune system enhancement

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 289, С. 138633 - 138633

Опубликована: Дек. 13, 2024

Язык: Английский

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Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD

Antioxidants, Год журнала: 2025, Номер 14(1), С. 56 - 56

Опубликована: Янв. 6, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic condition marked by excessive lipid accumulation in hepatic tissue. This disorder can lead to range of pathological outcomes, including metabolic steatohepatitis (MASH) and cirrhosis. Despite extensive research, the molecular mechanisms driving MASLD initiation progression remain incompletely understood. Oxidative stress peroxidation are pivotal "multiple parallel hit model", contributing cell death tissue damage. Gut microbiota plays substantial role modulating oxidative through multiple pathways: impairing intestinal barrier, which results bacterial translocation inflammation; modifying bile acid structure, impacts signaling cascades involved lipidic metabolism; influencing hepatocytes' ferroptosis, form programmed death; regulating trimethylamine N-oxide (TMAO) activating platelet function, both recently identified as pathogenetic factors MASH progression. Moreover, various exogenous impact gut its involvement MASLD-related stress, such air pollution, physical activity, cigarette smoke, alcohol, dietary patterns. manuscript aims provide state-of-the-art overview focused on intricate interplay between microbiota, peroxidation, pathogenesis, offering insights into potential strategies prevent associated complications.

Язык: Английский

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The bilateral cross communication in microbiota-gut-brain axis as a promising therapeutic target for Alzheimer’s disease: a focus on neuroinflammation

Deleted Journal, Год журнала: 2025, Номер 2(1)

Опубликована: Фев. 11, 2025

Abstract The microbiota- gut-brain interaction is a fundamental aspect of the synergy between microbiota and host in accessing signaling pathways to modulate brain function behavior. bilateral cross-communication, which might be direct or indirect, within line axis becoming promising therapeutic target for central nervous system (CNS) disorders, including Alzheimer’s disease (AD). Dysbiosis creates an imbalance abundance pro-inflammatory anti-inflammatory species, species’ availability may vary based on type neurodegenerative diseases. final outcome (i.e., dysbiosis) follows similar approach, leading shift towards state gut, increased gut permeability, triggered peripheral inflammatory response consequently occurs. To fully exploit impact interventions AD, scientific investigations help understand complex neuroinflammatory mechanisms investigating potential modulating future therapies.

Язык: Английский

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