A retrospective cohort study on early antibiotic use in vaccinated and unvaccinated COVID‐19 patients
Journal of Medical Virology,
Год журнала:
2024,
Номер
96(3)
Опубликована: Март 1, 2024
Abstract
The
bacteriophage
behavior
of
SARS‐CoV‐2
during
the
acute
and
post‐COVID‐19
phases
appears
to
be
an
important
factor
in
development
disease.
early
use
antibiotics
seems
crucial
inhibit
disease
progression—to
prevent
viral
replication
gut
microbiome,
control
toxicological
production
from
human
microbiome.
To
study
impact
specific
on
recovery
COVID‐19
long
COVID
(LC)
taking
into
account:
vaccination
status,
comorbidities,
wave,
time
initiation
antibiotic
therapy
concomitant
corticosteroids
nonsteroidal
anti‐inflammatory
drugs
(NSAIDs).
A
total
211
patients
were
included
study:
which
59
vaccinated
with
mRNA
vaccines
against
while
152
unvaccinated.
Patients
enrolled
three
waves:
September
2020
October
2022,
corresponding
emergence
pre‐Delta,
Delta,
Omicron
variants
virus.
criteria
for
enrolling
were:
oropharyngeal
swab
positivity
or
fecal
findings;
moderate
symptoms
intake;
measurement
blood
oxygen
saturation
period
illness.
combinations,
such
as
amoxicillin
clavulanic
acid
(875
+
125
mg
tablets,
every
12
h)
plus
rifaximin
(400
tablets
h),
first
choice,
suggested
previous
data,
azithromycin
(500
24
above,
allows
healthcare
professionals
focus
microbiome
its
implications
patient
care.
primary
outcome
measured
this
was
estimated
average
treatment
effect,
quantified
difference
mean
between
receiving
those
not
at
3
9
days
after
start
treatment.
In
analysis,
both
unvaccinated
groups
had
a
median
illness
duration
7
(interquartile
range
[IQR]
6–9
each;
crude
hazard
ratio
[HR]
=
0.94,
p
0.700).
pre‐Delta
Delta
waves
8
(IQR
7–10
days),
it
shorter,
6.5
days,
6–8
days;
HR
1.71,
<
0.001).
These
results
confirmed
by
multivariate
analysis.
comorbidities
significantly
longer
duration:
days)
compared
without
(crude
0.75,
0.038),
but
result
analysis
statistical
significance
lost.
Early
resulted
shorter
4.74,
Concomitant
NSAIDs
did
reduce
prolonged
(
0.041).
subgroup
42
3–6
(median
IQR
8–10
others
0.542,
0.001),
also
adjusted
HR.
study,
statistically
significant
reduction
observed
among
who
received
played
role
maintaining
higher
levels
saturation.
addition,
is
worth
noting
that
number
phase
develop
LC.
Язык: Английский
Interplay between Multisystem Inflammatory Syndrome in Children, Interleukin 6, Microbiome, and Gut Barrier Integrity
Immuno,
Год журнала:
2024,
Номер
4(3), С. 226 - 246
Опубликована: Авг. 18, 2024
A
severe
consequence
of
SARS-CoV-2
infection
that
manifests
as
systemic
inflammation
and
multi-organ
involvement
is
called
Multisystem
Inflammatory
Syndrome
in
Children
(MIS-C).
This
review
examines
the
possible
relationship
between
gut
barrier
integrity,
microbiome,
dysregulation
interleukin
6
(IL-6)
signaling,
MIS-C.
Clinical
biochemical
features
MIS-C
are
comparable
to
those
other
hyper-inflammatory
syndromes,
suggesting
a
dysregulated
immune
response.
One
explanation
for
seen
patients
SARS-CoV-2-induced
IL-6
signaling
pathway.
In
addition,
new
data
suggest
reciprocal
link
integrity
IL-6.
exhibits
bacteriophage-like
behavior,
highlighting
role
bacteria
reservoir
virus
emphasizing
importance
understanding
bacteriophagic
mechanism
fecal–oral
transmission.
The
increased
translocation
viral
products
bacterial
toxins
may
result
from
disrupting
intestinal
cause
inflammation.
On
hand,
can
weaken
barrier,
which
feeds
back
into
loop
immunological
dysregulation.
context
MIS-C,
interaction
infection,
IL-6,
shed
light
on
etiology
disease
guide
treatment
options.
Since
children
with
dysbiosis
be
more
susceptible
it
critical
reinforce
their
microbiome
through
probiotics
supplementation,
plant-fiber-rich
diets
(prebiotics).
Early
antibiotic
use
zonulin
antagonists
should
also
considered.
Язык: Английский
The essential role of prebiotics in restoring gut health in long COVID
Progress in molecular biology and translational science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Blood Transcriptome Profiling Highlights the Role of Intestinal Bacterial Translocation in Severe COVID-19
Pathogens,
Год журнала:
2025,
Номер
14(4), С. 381 - 381
Опубликована: Апрель 14, 2025
COVID-19
has
caused
millions
of
deaths
globally;
however,
the
characterization
molecular
biomarkers
severe
disease
remains
great
scientific
importance.
The
aim
this
study
was
to
capture
transcriptional
differences
whole
blood
gene
expression
between
patients
with
mild
and
disease,
using
Next
Generation
Sequencing
technologies,
on
admission
after
7
days.
genes
which
were
differentially
expressed
in
compared
used
for
Gene
Ontology
(GO)
enrichment
analysis.
data
estimate
cell
abundance
22
immune
types
via
digital
cytometry.
GO
terms
related
response
molecules
bacterial
origin,
such
as
intestine-derived
lipopolysaccharide
(LPS),
enriched,
among
other
dysregulated
pathways,
are
well
described
paramount
mechanisms
manifestations
COVID-19.
neutrophil
population
increased
whereas
monocyte,
CD8+
T
cell,
activated
Natural
Killer
(NK)
populations
depleted.
These
dynamics
also
indicative
intestinal
translocation.
This
elucidates
basis
highlights
translocation
a
potential
driver
disease.
Язык: Английский
Reply to the letter of Thiruchelvam K. et al
Journal of Medical Virology,
Год журнала:
2024,
Номер
96(8)
Опубликована: Авг. 1, 2024
Язык: Английский
Could the Spike Protein Derived from mRNA Vaccines Negatively Impact Beneficial Bacteria in the Gut?
COVID,
Год журнала:
2024,
Номер
4(9), С. 1368 - 1378
Опубликована: Авг. 25, 2024
The
emergence
of
mRNA
vaccines
for
SARS-CoV-2
has
opened
a
new
page
in
vaccine
development.
Nevertheless,
concerns
experts
have
been
expressed
about
unintentional
side
effects
on
the
gut
microbiota
(GM).
Previous
studies
showed
that
this
virus
acts
as
bacteriophage,
which
infects
and
destroys
specific
bacterial
strains
GM.
present
manuscript
hypothesizes
synthetic
spike
protein
could
create
changes
composition
functioning
GM
by
entering
intestinal
cells
after
vaccination
impairing
symbiotic
relationship
between
An
experimental
protocol
to
test
hypothesis
is
suggested.
Язык: Английский