Proceedings of the National Academy of Sciences,
Год журнала:
2018,
Номер
115(29)
Опубликована: Июнь 29, 2018
Significance
Intrinsically
photosensitive
retinal
ganglion
cells
(ipRGCs)
exhibit
several
important
functions
including
the
circadian
photo
entrainment,
pupillary
light
reflex,
alertness,
and
phototaxis.
Whether
ipRGCs
regulate
other
physiological
activities
is
unknown.
We
show
that
external
stimulation
can
activate
hair
follicle
stem
through
eyes
via
an
ipRGC–suprachiasmatic
nucleus–sympathetic
nervous
circuit.
Immediately
after
are
stimulated
by
light,
systemic
sympathetic
activated.
In
skin,
local
release
of
norepinephrine
activates
cells.
This
neural
circuit
enables
prompt
communication
between
peripheral
tissues
environment.
Due
to
activation
activities,
this
also
allow
for
timely
responses
in
organs.
It
highlights
a
function
regulating
autonomic
activity.
Circulation Research,
Год журнала:
2024,
Номер
134(6), С. 675 - 694
Опубликована: Март 14, 2024
The
impact
of
circadian
rhythms
on
cardiovascular
function
and
disease
development
is
well
established,
with
numerous
studies
in
genetically
modified
animals
emphasizing
the
molecular
clock's
significance
pathogenesis
pathophysiology
myocardial
ischemia
heart
failure
progression.
However,
translational
preclinical
targeting
heart's
biology
are
just
now
emerging
leading
to
a
novel
field
medicine
termed
medicine.
In
this
review,
we
explore
mechanisms
therapies,
including
(1)
intense
light,
(2)
small
molecules
modulating
mechanism,
(3)
chronotherapies
such
as
drugs
meal
timings.
These
promise
significant
clinical
translation
for
disease.
(4)
Additionally,
address
differential
functioning
mechanism
males
versus
females,
consideration
biological
sex,
gender,
aging
therapies
Current Biology,
Год журнала:
2016,
Номер
26(17), С. 2358 - 2363
Опубликована: Июль 16, 2016
Functional
imaging
and
psychometric
assessments
indicate
that
bright
light
can
enhance
mood,
attention,
cognitive
performance
in
humans.
Indirect
evidence
links
these
events
to
detection
by
intrinsically
photosensitive
melanopsin-expressing
retinal
ganglion
cells
(mRGCs)
[1-9].
However,
there
is
currently
no
direct
demonstration
mRGCs
have
such
an
immediate
effect
on
mood
or
behavioral
state
any
species.
We
addressed
this
deficit
using
chemogenetics
selectively
activate
mRGCs,
simulating
the
excitatory
effects
of
cell
type
dark-housed
mice.
This
specific
manipulation
evoked
circadian
phase
resetting
pupil
constriction
(known
consequences
mRGC
activation).
It
also
induced
c-Fos
(a
marker
neuronal
activation)
multiple
nuclei
hypothalamus
(paraventricular,
dorsomedial,
lateral
hypothalamus),
thalamus
(paraventricular
centromedian
thalamus),
limbic
system
(amygdala
nucleus
accumbens).
These
regions
influence
numerous
aspects
autonomic
neuroendocrine
activity
are
typically
active
during
periods
wakefulness
arousal.
By
contrast,
was
absent
from
ventrolateral
preoptic
area
(active
sleep).
In
standard
tests
(open
field
elevated
plus
maze),
activation
behaviors
commonly
interpreted
as
anxiety
like
signs
increased
alertness.
Similar
changes
behavior
could
be
wild-type
rodless
coneless
mice,
but
not
melanopsin
knockout
data
demonstrate
drive
a
light-dependent
switch
motivation
toward
more
alert,
risk-averse
state.
They
highlight
ability
small
fraction
realign
brain
defining
widespread
physiology
behavior.
The Journal of Comparative Neurology,
Год журнала:
2018,
Номер
526(13), С. 2010 - 2018
Опубликована: Июнь 11, 2018
In
addition
to
its
well-known
role
in
pattern
vision,
light
influences
a
wide
range
of
non-image
forming,
subconscious
visual
behaviors
including
circadian
photoentrainment,
sleep,
mood,
learning,
and
the
pupillary
reflex.
Each
these
is
thought
require
input
from
M1
subtype
melanopsin-expressing,
intrinsically
photosensitive
retinal
ganglion
cell
(ipRGC).
Recent
work
has
demonstrated
that
ipRGC
can
be
further
subdivided
based
on
expression
transcription
factor
Brn3b.
Brn3b-positive
ipRGCs
project
olivary
pretectal
nucleus
are
necessary
for
reflex,
while
Brn3b-negative
suprachiasmatic
(SCN)
sufficient
photoentrainment.
However,
beyond
pupil
systems,
little
known
about
projection
patterns
subtypes.
Here
we
show
comprise
majority
sparse
inputs
thalamus,
midbrain,
hypothalamus.
Our
data
demonstrate
very
few
brain
targets
receive
convergent
both
subpopulations,
suggesting
each
subpopulation
drives
specific
subset
light-driven
behaviors.
Proceedings of the National Academy of Sciences,
Год журнала:
2018,
Номер
115(29)
Опубликована: Июнь 29, 2018
Significance
Intrinsically
photosensitive
retinal
ganglion
cells
(ipRGCs)
exhibit
several
important
functions
including
the
circadian
photo
entrainment,
pupillary
light
reflex,
alertness,
and
phototaxis.
Whether
ipRGCs
regulate
other
physiological
activities
is
unknown.
We
show
that
external
stimulation
can
activate
hair
follicle
stem
through
eyes
via
an
ipRGC–suprachiasmatic
nucleus–sympathetic
nervous
circuit.
Immediately
after
are
stimulated
by
light,
systemic
sympathetic
activated.
In
skin,
local
release
of
norepinephrine
activates
cells.
This
neural
circuit
enables
prompt
communication
between
peripheral
tissues
environment.
Due
to
activation
activities,
this
also
allow
for
timely
responses
in
organs.
It
highlights
a
function
regulating
autonomic
activity.
