Nature and Science of Sleep, Год журнала: 2022, Номер Volume 14, С. 25 - 39
Опубликована: Янв. 1, 2022
This perspective considers the possibility that daytime's intrusion into night made possible by electric lighting may not be as pernicious to sleep and circadian health encroachment of nighttime day wrought 20th century architectural practices have left many people estranged from sunlight.
Язык: Английский
Neuron, Год журнала: 2019, Номер 104(2), С. 205 - 226
Опубликована: Окт. 1, 2019
Язык: Английский
Процитировано
243
LEUKOS The Journal of the Illuminating Engineering Society of North America, Год журнала: 2021, Номер 18(3), С. 387 - 414
Опубликована: Март 26, 2021
Architectural lighting has potent biological effects but applied practices that capitalize on this potential have been limited. In review, we endeavor to consolidate and synthesize key references will be useful for professionals, with the goal of supporting knowledge translation into pragmatic strategies. Specifically, explain relevant terminology, outline basic concepts, identify references, provide a balanced overview current state knowledge, highlight important remaining questions. We summarize physiological light human health well-being, including description processes underlying photic regulation circadian, neuroendocrine, neurobehavioral functions. review seminal work elucidating elements mediating potency these responses, specific attention factors critical interpreting those findings. parallel, endorse melanopic Equivalent Daylight Illuminance (Ev,melD65) as preferred measure quantify light. Ultimately, while future studies are necessary further facilitate laboratory domestic workplace settings, immediate better support is clear. Aiming integrative solutions biologically high during day low night perhaps most improvement made in order applications humans.
Язык: Английский
Процитировано
142
Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(3), С. 159 - 175
Опубликована: Янв. 26, 2024
Язык: Английский
Процитировано
24
Cellular and Molecular Life Sciences, Год журнала: 2020, Номер 78(3), С. 889 - 907
Опубликована: Сен. 23, 2020
Язык: Английский
Процитировано
135
eLife, Год журнала: 2019, Номер 8
Опубликована: Июль 23, 2019
The light environment greatly impacts human alertness, mood, and cognition by both acute regulation of physiology indirect alignment circadian rhythms. These processes require the melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), but relevant downstream brain areas involved remain elusive. ipRGCs project widely in brain, including to central pacemaker, suprachiasmatic nucleus (SCN). Here we show that body temperature sleep responses exposure are absent after genetic ablation all except a subpopulation projects SCN. Furthermore, chemogenetic activation avoid SCN, these sufficient for changes temperature. Our results challenge idea SCN is major relay effects on non-image forming behaviors identify sensory initiate light's profound sleep.
Язык: Английский
Процитировано
101
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 28, 2025
Abstract The retina contains distinct types of ganglion cells, which form mosaics with cells each type at position the visual field. Displaced retinal (dRGCs) occur cell bodies in inner nuclear layer (INL), and regularly placed RGCs layer. An example mammalian dRGCs are M1-type intrinsically photosensitive (ipRGCs). Little is known, however, about their relationship ipRGCs. We identified mouse ipRGC M1, M2, M4/sONɑ by immunohistochemistry light microscopy. Reconstruction immunolabeled from M1 sONɑ indicated that tiled regular RGC partners. Multi-electrode array recordings revealed conventional receptive fields displaced fit into mosaic counterparts. distribution analysis showed type-specific dRGC patterns followed neither global density all nor local densities corresponding types. displacement INL occurs a type-dependent manner, where positioned to complete Our data suggest serve same functional role within population RGCs.
Язык: Английский
Процитировано
2
Frontiers in Neurology, Год журнала: 2019, Номер 10
Опубликована: Фев. 12, 2019
The pupillary light reflex is mediated by melanopsin-containing intrinsically-photosensitive retinal ganglion cells (ipRGCs), which also receive input from rods and cones. Melanopsin-dependent responses are short-wavelength sensitive, have a higher threshold of activation, much slower to activate de-activate compared with rod/cone-mediated responses. Given that rod/cone photoreceptors melanopsin differ in their response properties, stimuli can be designed stimulate preferentially each the different photoreceptor types, providing read-out function. This has given rise chromatic pupillometry methods aim assess health outer ipRGCs measuring blue or red stimuli. Here, we review types protocols been tested patients optic nerve disease, including approaches use short-duration exposures continuous exposure light. Across protocols, disease (e.g., retinitis pigmentosa Leber congenital amaurosis) show reduced absent dim blue-light used rod function, moderately-bright red-light cone By comparison, glaucoma ischemic neuropathy, but not mitochondrial disease) impaired during bright stimuli, post-illumination after offset, These proof-of-concept studies demonstrate damage ipRGCs. In future studies, it will important determine whether for screening early detection diseases. Such may prove useful objectively evaluating degree recovery ipRGC function blind who undergo gene therapy other treatments restore vision.
Язык: Английский
Процитировано
64
The Journal of Comparative Neurology, Год журнала: 2020, Номер 528(12), С. 2044 - 2067
Опубликована: Янв. 31, 2020
Melanopsin ganglion cells have defied convention since their discovery almost 20 years ago. In the following, many types of these intrinsically photosensitive retinal (ipRGCs) emerged. mouse retina, there are currently six known (M1-M6) melanopsin cells, each with unique morphology, mosaics, connections, physiology, projections, and functions. While melanopsin-expressing usually associated behaviors like circadian photoentrainment pupillary light reflex, characterization multiple has demonstrated a reach that may extend far beyond non-image-forming vision. fact, studies shown individual potential to impact image-forming functions contrast sensitivity color opponency. Thus, goal this review is summarize morphological functional aspects in retina highlight respective roles Although cell do project brain targets, it important note only first step determining influence on Even so, visual system canonically been divided into two realms begun challenge boundary between them, providing an overlap information complementary rather than redundant. Further photoreceptors will no doubt continue illustrate ever-expanding role for
Язык: Английский
Процитировано
59
Science Advances, Год журнала: 2023, Номер 9(12)
Опубликована: Март 22, 2023
Light modulates mood through various retina-brain pathways. We showed that mice treated with short-term acute bright light exposure displayed anxiety-related phenotypes in a prolonged manner even after the termination of exposure. Such postexposure anxiogenic effect depended upon melanopsin-based intrinsically photosensitive retinal ganglion cell (ipRGC) activities rather than rod/cone photoreceptor inputs. Chemogenetic manipulation specific central nuclei demonstrated ipRGC-central amygdala (CeA) visual circuit played key role this effect. The corticosterone system was likely to be involved effect, as evidenced by enhanced expression glucocorticoid receptor (GR) protein CeA and bed nucleus stria terminalis absence animals GR antagonist. Together, our findings reveal non-image forming specifically designed for "the delayed" extinction anxiety against potential threats, thus conferring survival advantage.
Язык: Английский
Процитировано
22
Neuroscience Bulletin, Год журнала: 2023, Номер 40(3), С. 350 - 362
Опубликована: Авг. 9, 2023
Abstract Light is a powerful environmental factor influencing diverse brain functions. Clinical evidence supports the beneficial effect of light therapy on several diseases, including depression, cognitive dysfunction, chronic pain, and sleep disorders. However, precise mechanisms underlying effects are still not well understood. In this review, we critically evaluate current clinical showing diseases. addition, introduce research progress regarding neural circuit modulatory functions, mood, memory, pain perception, sleep, circadian rhythm, development, metabolism.
Язык: Английский
Процитировано
22