Elsevier eBooks, Год журнала: 2020, Номер unknown, С. 458 - 476
Опубликована: Фев. 24, 2020
Язык: Английский
Elsevier eBooks, Год журнала: 2020, Номер unknown, С. 458 - 476
Опубликована: Фев. 24, 2020
Язык: Английский
Nature Reviews Microbiology, Год журнала: 2018, Номер 17(3), С. 167 - 180
Опубликована: Дек. 10, 2018
Язык: Английский
Процитировано
1079Applied Microbiology and Biotechnology, Год журнала: 2018, Номер 102(22), С. 9481 - 9515
Опубликована: Окт. 6, 2018
This review presents an update on the current knowledge of secondary metabolite potential major fungal species used in industrial biotechnology, i.e., Aspergillus niger, oryzae, and Trichoderma reesei. These have a long history safe use for enzyme production. Like most microorganisms that exist challenging environment nature, these fungi can produce large variety number metabolites. Many compounds present several properties make them attractive different medical applications. A description all known metabolites produced by is presented here. Mycotoxins are very limited group be pose health hazards humans other vertebrates when ingested small amounts. Some mycotoxins species-specific. Here, we scientific basis (1) definition including their toxicity (2) clarity misclassification mycotoxin reported literature, e.g., A. oryzae has been wrongly as aflatoxin producer, due to flavus strains. It therefore paramount importance accurately describe potentially production organism ensure strains not capable producing during intended reference paper authorities, companies, researchers dealing with assessment, risk evaluation food or feed production, considerations hosts.
Язык: Английский
Процитировано
275Nature Reviews Microbiology, Год журнала: 2018, Номер 16(12), С. 731 - 744
Опубликована: Сен. 7, 2018
Язык: Английский
Процитировано
184BMC Genomics, Год журнала: 2019, Номер 20(1)
Опубликована: Дек. 1, 2019
Abstract Background The dominant fungi in arid grasslands and shrublands are members of the Ascomycota phylum. important drivers carbon nitrogen cycling ecosystems. These play roles soil stability, plant biomass decomposition, endophytic interactions with plants. They may also form symbiotic associations biocrust components or be latent saprotrophs pathogens that live on tissues. However, their functional potential soils, where organic matter, nutrients water very low only periodically available, is poorly characterized. Results Five were isolated from different crust microhabitats rhizosphere soils around native bunchgrass Pleuraphis jamesii an grassland near Moab, UT, USA. Putative genera Coniochaeta , lichen biocrust, Embellisia cyanobacteria Chaetomium below Phoma a moss microhabitat, Aspergillus soil. grown replicate cultures sources (chitin, pine wood) relevant to sources. Secretomes produced by each substrate demonstrate these likely interact primary producers (biocrust plants) secreting wide range proteins facilitate associations. Each fungal isolates secreted enzymes degrade biomass, small effector proteins, involved either beneficial virulence. expressed more degrading when grass- pine-containing than chitin. similar numbers under all conditions, while grass-containing cultures. Conclusions This study genomes secretomes provides insights about lifestyles grassland, exact nature those interactions, whether any true endophytes, opportunistic phytopathogens, will topic future studies.
Язык: Английский
Процитировано
184Frontiers in Plant Science, Год журнала: 2021, Номер 12
Опубликована: Дек. 17, 2021
Endophytic fungi (EF) are a group of fascinating host-associated fungal communities that colonize the intercellular or intracellular spaces host tissues, providing beneficial effects to their hosts while gaining advantages. In recent decades, accumulated research on endophytic has revealed biodiversity, wide-ranging ecological distribution, and multidimensional interactions with plants other microbiomes in symbiotic continuum. this review, we highlight role secondary metabolites (SMs) as effectors these interactions, biosynthesis SMs symbiosis via complex gene expression regulation mechanisms continuum mimicry alteration phytochemical production plants. Alternative biological applications modern medicine, agriculture, industry major classes also discussed. This review recapitulates an introduction background, progress, prospects biology, discusses problems substantive challenges need further study.
Язык: Английский
Процитировано
180Annual Review of Genetics, Год журнала: 2018, Номер 52(1), С. 159 - 183
Опубликована: Сен. 5, 2018
In bacteria, more than half of the genes in genome are organized operons. contrast, eukaryotes, functionally related usually dispersed across genome. There are, however, numerous examples functional clusters nonhomologous for metabolic pathways fungi and plants. Despite superficial similarities with operons (physical clustering, coordinate regulation), these have not originated by horizontal gene transfer from (unlike operons) typically transcribed separately rather as a single polycistronic message. This clustering phenomenon raises intriguing questions about origins clustered eukaryotes significance pathway function. Here we review plants, highlight commonalities differences, consider how form regulated. We also identify opportunities future research areas large-scale genomics, synthetic biology, experimental evolution.
Язык: Английский
Процитировано
163Natural Product Reports, Год журнала: 2020, Номер 37(7), С. 868 - 878
Опубликована: Янв. 1, 2020
This
highlight
synthesizes
knowledge
of
the
molecular
evolutionary
processes
–
functional
divergence,
horizontal
transfer,
and
Язык: Английский
Процитировано
131Genome Medicine, Год журнала: 2018, Номер 10(1)
Опубликована: Окт. 24, 2018
Links between colorectal cancer (CRC) and the gut microbiome have been established, but specific microbial species their role in carcinogenesis remain an active area of inquiry. Our understanding would be enhanced by better accounting for tumor subtype, community interactions, metabolism, ecology.
Язык: Английский
Процитировано
120Microbial Genomics, Год журнала: 2019, Номер 5(2)
Опубликована: Фев. 1, 2019
The concept of the species ‘pan-genome’, union ‘core’ conserved genes and all ‘accessory’ non-conserved across strains a species, was first proposed in prokaryotes to account for intraspecific variability. Species pan-genomes have been extensively studied prokaryotes, but evidence has also demonstrated eukaryotes such as plants fungi. Using previously published methodology based on sequence homology microsynteny, addition bespoke pipelines, we investigated four model fungal species: Saccharomyces cerevisiae , Candida albicans Cryptococcus neoformans var. grubii Aspergillus fumigatus . Between 80 90 % gene models per strain each these are core that highly many which involved housekeeping survival processes. In remaining clustered within subterminal regions may be pathogenesis antimicrobial resistance. Analysis ancestry accessory genomes suggests evolve by strain-level innovations duplication opposed wide-scale horizontal transfer. Our findings lend further supporting existence eukaryote taxa.
Язык: Английский
Процитировано
99Nature Microbiology, Год журнала: 2021, Номер 6(12), С. 1526 - 1536
Опубликована: Ноя. 24, 2021
Язык: Английский
Процитировано
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