Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior

Progress in Neurobiology, Год журнала: 2019, Номер 179, С. 101607 - 101607

Опубликована: Март 22, 2019

Язык: Английский

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Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation

Cell, Год журнала: 2019, Номер 178(4), С. 901 - 918.e16

Опубликована: Авг. 1, 2019

Physiology and metabolism are often sexually dimorphic, but the underlying mechanisms remain incompletely understood. Here, we use intestine of Drosophila melanogaster to investigate how gut-derived signals contribute sex differences in whole-body physiology. We find that carbohydrate handling is male-biased a specific portion intestine. In contrast known sexual dimorphisms invertebrates, intestinal extrinsically controlled by adjacent male gonad, which activates JAK-STAT signaling enterocytes within this portion. Sex reversal experiments establish roles for metabolic state controlling food intake sperm production through citrate. Our work uncovers gonad-gut axis coupling diet production, revealing communication across organs physiologically important. The instructive role citrate inter-organ might be significant more biological contexts than previously recognized.

Язык: Английский

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Regulation of Body Size and Growth Control

Genetics, Год журнала: 2020, Номер 216(2), С. 269 - 313

Опубликована: Окт. 1, 2020

Abstract The control of body and organ growth is essential for the development adults with proper size proportions, which important survival reproduction. In animals, adult determined by rate duration juvenile growth, are influenced environment. nutrient-scarce environments in more time needed period can be extended delaying maturation, whereas rapidly completed nutrient-rich conditions. This flexibility requires integration environmental cues developmental signals that govern internal checkpoints to ensure maturation does not begin until sufficient tissue has occurred reach a size. Target Rapamycin (TOR) pathway primary cell-autonomous nutrient sensor, while circulating hormones such as steroids insulin-like factors main systemic regulators animals. We discuss recent findings Drosophila melanogaster showing environment growth-sensing mechanisms, involving TOR other growth-regulatory pathways, converge on insulin steroid relay centers responsible adjusting development, response external addition this, also monitored coordinated whole-body timing through modulation signaling. coordination involves interorgan communication mediated peptide 8 status. Together, these multiple nutritional feed into neuroendocrine hubs controlling signaling, serving at progression toward delayed. review focuses mechanisms conditions modulate size, highlights conserved architecture this system, made prime model understanding

Язык: Английский

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Metabolism and growth adaptation to environmental conditions in Drosophila

Cellular and Molecular Life Sciences, Год журнала: 2020, Номер 77(22), С. 4523 - 4551

Опубликована: Май 24, 2020

Organisms adapt to changing environments by adjusting their development, metabolism, and behavior improve chances of survival reproduction. To achieve such flexibility, organisms must be able sense respond changes in external environmental conditions internal state. Metabolic adaptation response altered nutrient availability is key maintaining energy homeostasis sustaining developmental growth. Furthermore, variables exert major influences on growth final adult body size animals. This plasticity depends adaptive responses state cues that are essential for processes. Genetic studies have shown the fruit fly Drosophila, similarly mammals, regulates its growth, environment through several hormones including insulin, peptides with glucagon-like function, steroid hormones. Here we review emerging evidence showing various sensed different organs that, via inter-organ communication, relay information neuroendocrine centers control insulin signaling. focuses endocrine regulation highlighting recent advances role system as a signaling hub integrates inputs drives responses.

Язык: Английский

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The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells

Cell Reports, Год журнала: 2019, Номер 29(12), С. 4172 - 4185.e5

Опубликована: Дек. 1, 2019

Enteroendocrine cells (EEs) in the intestinal epithelium have important endocrine functions, yet this cell lineage exhibits great local and regional variations that hampered detailed characterization of EE subtypes. Through single-cell RNA-sequencing analysis, combined with a collection peptide hormone receptor knockin strains, here we provide comprehensive analysis cellular diversity, spatial distribution, transcription factor (TF) code EEs adult Drosophila midgut. We identify 10 major subtypes totally produced approximately 14 different classes peptides. Each on average co-produces 2–5 Functional screen subtype-enriched TFs suggests combinatorial TF controls diversity; class-specific Mirr Ptx1 respectively define two EEs, such as Esg, Drm, Exex, Fer1 further identity. Our data should greatly facilitate modeling differentiation function.

Язык: Английский

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The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Авг. 10, 2021

Abstract The enteroendocrine cell (EEC)-derived incretins play a pivotal role in regulating the secretion of glucagon and insulins mammals. Although glucagon-like insulin-like hormones have been found across animal phyla, incretin-like EEC-derived not yet characterised invertebrates. Here, we show that midgut-derived hormone, neuropeptide F (NPF), acts as sugar-responsive, hormone fruit fly, Drosophila melanogaster . Secreted NPF is received by receptor corpora cardiaca insulin-producing cells. NPF-NPFR signalling resulted suppression production enhancement peptide secretion, eventually promoting lipid anabolism. Similar to loss incretin function mammals, midgut led significant metabolic dysfunction, accompanied lipodystrophy, hyperphagia, hypoglycaemia. These results suggest regulate sugar-dependent metabolism through only mammals but also insects.

Язык: Английский

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Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila

Cell Metabolism, Год журнала: 2021, Номер 33(7), С. 1279 - 1292

Опубликована: Июнь 16, 2021

Язык: Английский

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A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila

Nature Metabolism, Год журнала: 2022, Номер 4(11), С. 1532 - 1550

Опубликована: Ноя. 7, 2022

Abstract Animals must adapt their dietary choices to meet nutritional needs. How these needs are detected and translated into nutrient-specific appetites that drive food-choice behaviours is poorly understood. Here we show enteroendocrine cells of the adult female Drosophila midgut sense nutrients in response release neuropeptide F (NPF), which an ortholog mammalian Y-family gut-brain hormones. Gut-derived NPF acts on glucagon-like adipokinetic hormone (AKH) signalling induce sugar satiety increase consumption protein-rich food, adipose tissue promote storage ingested nutrients. Suppression NPF-mediated gut leads overconsumption while simultaneously decreasing intake yeast. Furthermore, gut-derived has a female-specific function promoting protein-containing food mated females. Together, our findings suggest NPF-to-AKH modulates specific regulates choice ensure homeostatic nutrients, providing insight hormonal mechanisms underlie hungers.

Язык: Английский

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Regulation of ecdysone production in Drosophila by neuropeptides and peptide hormones

Open Biology, Год журнала: 2021, Номер 11(2)

Опубликована: Фев. 1, 2021

In both mammals and insects, steroid hormones play a major role in directing the animal's progression through developmental stages. To maximize fitness outcomes, hormone production is regulated by environmental conditions experienced animal. ecdysone mediates transitions between stages response to factors such as nutrition. These signals are communicated ecdysone-producing gland via action of neuropeptide peptide signalling pathways. While some these pathways have been well characterized, there evidence suggest more than has previously thought function control production, potentially greater range conditions. Here, we review known regulate model genetic insect Drosophila melanogaster , what regarding that trigger Areas for future research highlighted can further contribute our overall understanding complex orchestration environmental, physiological cues together produce functioning adult organism.

Язык: Английский

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The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Фев. 4, 2022

Abstract The intestine is a central regulator of metabolic homeostasis. Dietary inputs are absorbed through the gut, which senses their nutritional value and relays hormonal information to other organs coordinate systemic energy balance. However, gut-derived hormones affecting behavioral responses poorly defined. Here we show that endocrine cells Drosophila gut sense nutrient stress mechanism involves TOR pathway in response secrete peptide hormone allatostatin C, somatostatin homolog. Gut-derived C induces secretion glucagon-like adipokinetic food intake mobilization. Loss Allatostatin or its receptor adipokinetic-hormone-producing impairs lipid sugar mobilization during fasting, leading hypoglycemia. Our findings illustrate nutrient-responsive maintains homeostasis under nutrient-stress conditions, function essential health whose failure can lead disorders.

Язык: Английский

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