An amuse-bouche of stem cell regulation: Underlying principles and mechanisms from adult Drosophila intestinal stem cells

Current Opinion in Cell Biology, Год журнала: 2021, Номер 73, С. 58 - 68

Опубликована: Июль 1, 2021

Язык: Английский

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Interorgan communication through peripherally derived peptide hormones in Drosophila

Fly, Год журнала: 2022, Номер 16(1), С. 152 - 176

Опубликована: Май 1, 2022

In multicellular organisms, endocrine factors such as hormones and cytokines regulate development homoeostasis through communication between different organs. For understanding interorgan communications factors, the fruit fly Drosophila melanogaster serves an excellent model system due to conservation of essential systems flies mammals availability powerful genetic tools. other insects, functions neuropeptides or peptide from central nervous have been extensively studied. However, a series recent studies conducted in revealed that derived peripheral tissues also play critical roles regulating multiple biological processes, including growth, metabolism, reproduction, behaviour. Here, we summarise advances target organs/tissues peripherally describe how these contribute various events communications.

Язык: Английский

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Investigating local and systemic intestinal signalling in health and disease with Drosophila

Disease Models & Mechanisms, Год журнала: 2022, Номер 15(3)

Опубликована: Март 1, 2022

ABSTRACT Whole-body health relies on complex inter-organ signalling networks that enable organisms to adapt environmental perturbations and changes in tissue homeostasis. The intestine plays a major role as centre by producing local systemic signals are relayed the body maintain intestinal organismal Consequently, disruption of homeostasis associated with diseases multi-organ dysfunction. In recent years, fruit fly Drosophila melanogaster has emerged prime model organism study tissue-intrinsic adult due its genetic tractability functional conservation mammals. this Review, we highlight research contributed our understanding how interacts microenvironment distant organs. We discuss implications these findings for whole-body pathophysiology, future studies might advance knowledge interplay between rest disease.

Язык: Английский

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From worms to humans: Understanding intestinal lipid metabolism via model organisms

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Год журнала: 2023, Номер 1868(4), С. 159290 - 159290

Опубликована: Фев. 3, 2023

Язык: Английский

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Circulating fructose regulates a germline stem cell increase via gustatory receptor–mediated gut hormone secretion in mated Drosophila

Science Advances, Год журнала: 2023, Номер 9(8)

Опубликована: Фев. 24, 2023

Oogenesis is influenced by multiple environmental factors. In the fruit fly, Drosophila melanogaster, nutrition and mating have large impacts on an increase in female germline stem cells (GSCs). However, it unclear whether these two factors affect this GSC interdependently. Here, we report that dietary sugars are crucial for after mating. Dietary glucose required mating-induced release of neuropeptide F (NPF) from enteroendocrine (EECs), followed NPF-mediated enhancement niche signaling. Unexpectedly, does not directly act NPF-positive EECs. Rather, contributes to elevation hemolymph fructose generated through polyol pathway. Elevated stimulates fructose-specific gustatory receptor, Gr43a, EECs, leading NPF secretion. This study demonstrates circulating fructose, derived sugars, a prerequisite leads egg production

Язык: Английский

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