Current Opinion in Microbiology,
Год журнала:
2023,
Номер
73, С. 102288 - 102288
Опубликована: Март 6, 2023
Most
of
the
variance
in
human
microbiome
remains
unexplained.
Although
an
extensive
list
individual
lifestyles
shaping
has
been
identified,
important
gaps
knowledge
persist.
data
are
from
individuals
living
socioeconomically
developed
countries.
This
may
have
skewed
interpretation
and
its
relationship
to
health
disease.
Moreover,
striking
under-representation
minority
groups
studies
is
a
missed
opportunity
assess
context,
history
changing
nature
relation
risk
Therefore,
we
focus
here
on
areas
recent
progress
-
ageing
ethnicity
both
which
contribute
with
particular
lessons
for
promise
microbiome-based
diagnostics
therapeutics.
Advances in Nutrition,
Год журнала:
2022,
Номер
13(5), С. 1450 - 1461
Опубликована: Июль 1, 2022
Humans
often
show
variable
responses
to
dietary,
prebiotic,
and
probiotic
interventions.
Emerging
evidence
indicates
that
the
gut
microbiota
is
a
key
determinant
for
this
population
heterogeneity.
Here,
we
provide
an
overview
of
some
major
computational
experimental
tools
being
applied
critical
questions
microbiota-mediated
personalized
nutrition
health.
First,
discuss
latest
advances
in
silico
modeling
microbiota-nutrition-health
axis,
including
application
statistical,
mechanistic,
hybrid
artificial
intelligence
models.
Second,
address
high-throughput
vitro
techniques
assessing
interindividual
heterogeneity,
from
ex
vivo
batch
culturing
stool
continuous
anaerobic
bioreactors,
more
sophisticated
organ-on-a-chip
models
integrate
both
host
microbial
compartments.
Third,
explore
approaches
better
understanding
personalized,
diet,
prebiotics,
probiotics,
nonhuman
animal
human
observational
studies,
feeding
trials
crossover
We
highlight
examples
existing,
consumer-facing
precision
platforms
are
currently
leveraging
microbiota.
Furthermore,
how
integration
broader
set
described
piece
can
generate
data
necessary
support
greater
diversity
strategies.
Finally,
present
vision
healthcare
future,
which
leverages
design
effective,
individual-specific
Nutrients,
Год журнала:
2022,
Номер
14(14), С. 2872 - 2872
Опубликована: Июль 13, 2022
The
core
microbiome,
which
refers
to
a
set
of
consistent
microbial
features
across
populations,
is
major
interest
in
microbiome
research
and
has
been
addressed
by
numerous
studies.
Understanding
the
can
help
identify
elements
that
lead
dysbiosis,
treatments
for
microbiome-related
health
states.
However,
defining
complex
task
at
several
levels.
In
this
review,
we
consider
current
state
human
research.
We
knowledge
gained,
factors
limiting
our
ability
achieve
reliable
description
fields
most
likely
improve
ability.
DNA
sequencing
technologies
methods
analyzing
metagenomics
amplicon
data
will
facilitate
higher
accuracy
resolution
describing
microbiome.
more
effort
should
be
invested
characterizing
microbiome's
interactions
with
its
host,
including
immune
system
nutrition.
Other
components
holobiontic
also
emphasized,
such
as
fungi,
protists,
lower
eukaryotes,
viruses,
phages.
Most
importantly,
collaborative
experts
microbiology,
nutrition,
immunology,
medicine,
systems
biology,
bioinformatics,
machine
learning
probably
required
traits
Cells,
Год журнала:
2022,
Номер
11(15), С. 2436 - 2436
Опубликована: Авг. 5, 2022
Rheumatoid
arthritis
is
a
chronic
systemic
immune-mediated
disease
caused
by
genetic
and
environmental
factors.
It
often
characterized
the
generation
of
autoantibodies
that
lead
to
synovial
inflammation
eventual
multi-joint
destruction.
A
growing
number
studies
have
shown
significant
differences
in
gut
microbiota
composition
rheumatoid
(RA)
patients
compared
healthy
controls.
Environmental
factors,
changes
diet
nutrition
are
thought
play
role
developing
this
dysbiosis.
This
review
aims
summarize
current
knowledge
intestinal
dysbiosis,
nutritional
its
implications
pathogenesis
autoimmunity.
The
future
direction
focuses
on
microbiome
manipulation
therapeutics
for
RA
management.
PLoS Biology,
Год журнала:
2023,
Номер
21(8), С. e3002230 - e3002230
Опубликована: Авг. 17, 2023
Human
microbiome
variation
is
linked
to
the
incidence,
prevalence,
and
mortality
of
many
diseases
associates
with
race
ethnicity
in
United
States.
However,
age
at
which
variability
emerges
between
these
groups
remains
a
central
gap
knowledge.
Here,
we
identify
that
gut
associated
arises
after
3
months
persists
through
childhood.
One-third
bacterial
taxa
vary
across
caregiver-identified
racial
categories
children
are
reported
also
adults.
Machine
learning
modeling
childhood
microbiomes
from
8
cohort
studies
(2,756
samples
729
children)
distinguishes
ethnic
87%
accuracy.
Importantly,
predictive
genera
among
top
30
most
important
when
used
predict
adult
self-identified
ethnicity.
Our
results
highlight
critical
developmental
window
or
shortly
social
environmental
factors
drive
ethnicity-associated
may
contribute
health
disparities.
The Lancet Microbe,
Год журнала:
2023,
Номер
4(12), С. e1063 - e1070
Опубликована: Ноя. 14, 2023
Whole-genome
sequencing
of
antimicrobial-resistant
pathogens
is
increasingly
being
used
for
antimicrobial
resistance
(AMR)
surveillance,
particularly
in
high-income
countries.
Innovations
genome
and
analysis
technologies
promise
to
revolutionise
AMR
surveillance
epidemiology;
however,
routine
adoption
these
challenging,
low-income
middle-income
As
part
a
wider
series
workshops
online
consultations,
group
experts
pathogen
genomics
computational
tool
development
conducted
situational
analysis,
identifying
the
following
under-used
innovations
genomic
surveillance:
clinical
metagenomics,
environmental
gene
or
plasmid
tracking,
machine
learning.
The
recommended
developing
cost-effective
use
cases
each
approach
mapping
data
outputs
outcomes
interest
justify
additional
investment
capacity,
training,
staff
required
implement
technologies.
Harmonisation
standardisation
methods,
creation
equitable
sharing
governance
frameworks,
will
facilitate
successful
implementation
innovations.
Frontiers in Oncology,
Год журнала:
2024,
Номер
13
Опубликована: Фев. 1, 2024
Gastrointestinal
(GI)
cancers
constitute
more
than
33%
of
new
cancer
cases
worldwide
and
pose
a
considerable
burden
on
public
health.
There
exists
growing
body
evidence
that
has
systematically
recorded
an
upward
trajectory
in
GI
malignancies
within
the
last
5
to
10
years,
thus
presenting
formidable
menace
health
human
population.
The
perturbations
microbiota
may
have
noteworthy
influence
advancement
cancers;
however,
precise
mechanisms
behind
this
association
are
still
not
comprehensively
understood.
Some
bacteria
been
observed
support
development,
while
others
seem
provide
safeguard
against
it.
Recent
studies
indicated
alterations
composition
abundance
microbiomes
could
be
associated
with
progression
various
cancers,
such
as
colorectal,
gastric,
hepatic,
esophageal
cancers.
Within
comprehensive
analysis,
we
examine
significance
microbiomes,
particularly
those
located
intestines,
Furthermore,
explore
impact
treatment
modalities
for
cancer,
including
chemotherapy,
immunotherapy,
radiotherapy.
Additionally,
delve
into
intricate
through
which
intestinal
microbes
efficacy
treatments.
