Human microbiome variance is underestimated DOI Creative Commons
Fergus Shanahan, Tarini Shankar Ghosh, Paul W. O’Toole

и другие.

Current Opinion in Microbiology, Год журнала: 2023, Номер 73, С. 102288 - 102288

Опубликована: Март 6, 2023

Most of the variance in human microbiome remains unexplained. Although an extensive list individual lifestyles shaping has been identified, important gaps knowledge persist. data are from individuals living socioeconomically developed countries. This may have skewed interpretation and its relationship to health disease. Moreover, striking under-representation minority groups studies is a missed opportunity assess context, history changing nature relation risk Therefore, we focus here on areas recent progress - ageing ethnicity both which contribute with particular lessons for promise microbiome-based diagnostics therapeutics.

Язык: Английский

The DTC microbiome testing industry needs more regulation DOI
Diane E. Hoffmann, Erik C. von Rosenvinge, Mary‐Claire Roghmann

и другие.

Science, Год журнала: 2024, Номер 383(6688), С. 1176 - 1179

Опубликована: Март 14, 2024

Tests lack analytical and clinical validity, requiring more federal oversight to prevent consumer harm

Язык: Английский

Процитировано

12
Menopausal shift on women’s health and microbial niches DOI Creative Commons
Maria Nieto, Maria J. Rus, Victoria Areal‐Quecuty

и другие.

npj Women s Health, Год журнала: 2025, Номер 3(1)

Опубликована: Янв. 14, 2025

Язык: Английский

Процитировано

2
Expanding the human gut microbiome atlas of Africa DOI Creative Commons
Dylan G. Maghini, Ovokeraye H. Oduaran, Luicer A. Ingasia

и другие.

Nature, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Population studies provide insights into the interplay between gut microbiome and geographical, lifestyle, genetic environmental factors. However, low- middle-income countries, in which approximately 84% of world's population lives1, are not equitably represented large-scale research2-4. Here we present AWI-Gen 2 Microbiome Project, a cross-sectional study sampling 1,801 women from Burkina Faso, Ghana, Kenya South Africa. By engaging with communities that range rural horticultural to post-industrial urban informal settlements, capture far greater breadth diversity. Using shotgun metagenomic sequencing, identify taxa geographic lifestyle associations, including Treponema Cryptobacteroides species loss Bifidobacterium gain populations. We uncover 1,005 bacterial metagenome-assembled genomes, antibiotic susceptibility as factor might drive succinifaciens absence Finally, find an HIV infection signature defined by several previously associated HIV, Dysosmobacter welbionis Enterocloster sp. This represents largest population-representative survey metagenomes African individuals so far, paired extensive clinical biomarkers demographic data, provides opportunity for microbiome-related discovery.

Язык: Английский

Процитировано

2
The impact of perinatal maternal stress on the maternal and infant gut and human milk microbiomes: A scoping review DOI Creative Commons
Niamh Ryan, Siobhain M. O’Mahony, Patricia Leahy‐Warren

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(2), С. e0318237 - e0318237

Опубликована: Фев. 28, 2025

Background Perinatal maternal stress, which includes both psychological and physiological stress experienced by healthy women during pregnancy the postpartum period, is becoming increasingly prevalent. Infant early exposure to adverse environments such as perinatal has been shown increase long-term risk metabolic, immunologic neurobehavioral disorders. Evidence suggests that human microbiome facilitates transmission of factors infants via vaginal, gut, milk microbiomes. The colonization aberrant microorganisms in mother’s microbiome, influenced microbiome-brain-gut axis, may be transferred a critical developmental period. This transfer predispose more inflammatory-prone associated with dysregulated metabolic process leading health outcomes. Given prevalence potential impact on infant health, no systematic mapping or review data date, aim this scoping gather evidence relationship between milk, maternal, gut Methods an exploratory review, guided Joanna Briggs Institute’s methodology along use Prisma Scr reporting guideline. A comprehensive search was conducted using following databases, CINAHL Complete; MEDLINE; PsycINFO, Web Science Scopus protocol registered Open Framework DOI 10.17605/OSF.IO/5SRMV. Results After screening 1145 papers there were 7 paper met inclusion criteria. Statistically significant associations found five studies identify higher abundance potentially pathogenic bacteria Erwinia, Serratia, T mayombie, Bacteroides lower levels linked beneficial Lactococcus, Lactobacillus, Akkermansia. However, one study presents conflicting results where it reported bacteria. Conclusion does have alteration diversity influential however, can affect colonisation different ways. These bacterial changes capacity influence long term disease. analyses collection tools methods, offers reasons for these findings well suggestions future research.

Язык: Английский

Процитировано

1
Human microbiome variance is underestimated DOI Creative Commons
Fergus Shanahan, Tarini Shankar Ghosh, Paul W. O’Toole

и другие.

Current Opinion in Microbiology, Год журнала: 2023, Номер 73, С. 102288 - 102288

Опубликована: Март 6, 2023

Most of the variance in human microbiome remains unexplained. Although an extensive list individual lifestyles shaping has been identified, important gaps knowledge persist. data are from individuals living socioeconomically developed countries. This may have skewed interpretation and its relationship to health disease. Moreover, striking under-representation minority groups studies is a missed opportunity assess context, history changing nature relation risk Therefore, we focus here on areas recent progress - ageing ethnicity both which contribute with particular lessons for promise microbiome-based diagnostics therapeutics.

Язык: Английский

Процитировано

23